NFL AI Predictions Week 1: ChatGPT Projections & ATS Picks for All 16 Games

Last Updated: September 4, 2025 12:54 PM EDT • 8 minute read X Social Google News Link

Think you can beat a robot in NFL picks? There's money to be made if you can - or you can tail our NFL AI predictions for Week 1 to back the trusty bot.
We've trained the latest model from ChatGPT to make its weekly NFL predictions and projected scores for all 16 games based on real-time search and advanced metrics, while offering a full box score and game preview for its five most confident picks.
If you can beat the bot in our free weekly NFL contest, you'll enter a draw to win SBR swag while competing for more than $5,000 in total prizes. So, what does our NFL prediction model expect as part of our Week 1 predictions?
🤖 NFL AI predictions for Week 1: Score projections & ATS picks
NFL AI predictions via ChatGPT simulation model with pick confidence based on a 1-to-5-star scale; check the latest NFL odds for the best odds.
Score prediction | ATS prediction | Confidence |
---|---|---|
Eagles 31, Cowboys 17 | Eagles -8 | ⭐⭐⭐ |
Chargers 24, Chiefs 23 | Chargers +3 | ⭐⭐⭐ |
Buccaneers 26, Falcons 23 | Buccaneers -1.5 | ⭐⭐ |
Browns 24, Bengals 23 | Browns +5.5 | ⭐⭐⭐ |
Colts 26, Dolphins 24 | Colts PK | ⭐⭐ |
Jaguars 30, Panthers 13 | Jaguars -3.5 | ⭐⭐⭐⭐ |
Patriots 20, Raiders 16 | Patriots -2.5 | ⭐⭐⭐ |
Cardinals 27, Saints 16 | Cardinals -6.5 | ⭐⭐⭐ |
Jets 23, Steelers 17 | Jets +2.5 | ⭐⭐⭐ |
Commanders 27, Giants 13 | Commanders -5.5 | ⭐⭐⭐⭐ |
Broncos 28, Titans 10 | Broncos -7.5 | ⭐⭐⭐⭐⭐ |
Seahawks 24, 49ers 20 | Seahawks +2.5 | ⭐⭐⭐ |
Packers 27, Lions 24 | Packers -2.5 | ⭐⭐⭐ |
Rams 26, Texans 23 | Rams -2.5 | ⭐⭐ |
Bills 31, Ravens 20 | Bills +1 | ⭐⭐⭐⭐ |
Bears 27, Vikings 23 | Bears +1.5 | ⭐⭐ |

🐎 Broncos (-7.5) vs. Titans

🚨 Titans vs. Broncos projected score
Team | 1Q | 2Q | 3Q | 4Q | Final |
---|---|---|---|---|---|
Titans | 3 | 0 | 7 | 0 | 10 |
Broncos | 7 | 7 | 7 | 7 | 28 |
🔢 Broncos projected stats
- Passing leader: Bo Nix – 22/32, 245 yards, 2 TD, 1 INT
- Rushing leader: J.K. Dobbins – 17 rushes, 84 yards, 1 TD
- Receiving leader: Courtland Sutton – 5 receptions, 82 yards, 1 TD
🔢 Titans projected stats
- Passing leader: Cam Ward – 19/33, 210 yards, 1 TD, 2 INT
- Rushing leader: Tony Pollard – 14 rushes, 52 yards
- Receiving leader: Calvin Ridley – 6 receptions, 71 yards
🔮 Titans vs. Broncos prediction
Denver has a clean path here. Bo Nix doesn’t need to be heroic - Sean Payton can lean on play-action, the quick game, and a steady run script behind a veteran line. With Courtland Sutton working the intermediate windows and Marvin Mims threatening vertically, the Broncos should stay on schedule and finish drives. The defense gets the friendliest end of the deal: at altitude against a first-start rookie in a loud building.
Tennessee’s pieces are interesting long-term, but Week 1 sets up rough. If the Titans can’t run efficiently with Tony Pollard on early downs, Cam Ward is staring at longer third downs against a rush that can heat up. One short field and a red-zone conversion or two is all Denver needs to create separation.
🐆 Jaguars (-3.5) vs. Panthers

🚨 Panthers vs. Jaguars projected score
Team | 1Q | 2Q | 3Q | 4Q | Final |
---|---|---|---|---|---|
Panthers | 3 | 3 | 0 | 7 | 13 |
Jaguars | 7 | 10 | 7 | 6 | 30 |
🔢 Jaguars projected stats
- Passing leader: Trevor Lawrence – 24/34, 277 yards, 2 TD
- Rushing leader: Travis Etienne Jr. – 17 rushes, 86 yards, 1 TD
- Receiving leader: Brian Thomas Jr. – 6 receptions, 82 yards, 1 TD
🔢 Panthers projected stats
- Passing leader: Bryce Young – 22/35, 215 yards, 1 TD, 1 INT
- Rushing leader: Chuba Hubbard – 13 rushes, 49 yards
- Receiving leader: Xavier Legette – 5 receptions, 64 yards
🔮 Panthers vs. Jaguars prediction
Jacksonville has a lot of ways to move the ball. Trevor Lawrence can lean on Travis Etienne’s versatility and a new-look receiver room with Brian Thomas Jr. and two-way phenom Travis Hunter. Doug Pederson should get to his quick-game staples early, then hunt isolated matchups once Carolina adjusts. The model likes sustained drives and multiple red-zone chances at home.
Carolina’s young wideouts are fun and Bryce Young looked more decisive this preseason, but this matchup asks the Panthers to protect and finish drives on the road. If Jacksonville’s front forces predictable passing situations, the Panthers’ offense can get choppy and settle for field goals.
🎖️ Commanders (-5.5) vs. Giants

🚨 Giants vs. Commanders projected score
Team | 1Q | 2Q | 3Q | 4Q | Final |
---|---|---|---|---|---|
Giants | 3 | 3 | 0 | 7 | 13 |
Commanders | 7 | 10 | 7 | 3 | 27 |
🔢 Commanders projected stats
- Passing leader: Jayden Daniels – 19/28, 226 yards, 1 TD
- Rushing leader: Austin Ekeler – 12 rushes, 47 yards
- Receiving leader: Terry McLaurin – 6 receptions, 74 yards
🔢 Giants projected stats
- Passing leader: Russell Wilson – 20/31, 204 yards, 1 TD, 1 INT
- Rushing leader: Tyrone Tracy Jr. – 12 rushes, 41 yards
- Receiving leader: Malik Nabers – 5 receptions, 66 yards
🔮 Giants vs. Commanders prediction
Washington is built to make life hard on you. Jayden Daniels adds designed runs and off-script answers, while Austin Ekeler, Terry McLaurin, and Deebo Samuel give easy buttons on key downs. With home crowd noise behind a deep front, the Commanders can keep their offense on short fields and avoid a punt-fest.
The Giants should take a step forward this year, but Week 1 asks Russell Wilson and a revamped skill group to hum right away. Malik Nabers will win some matchups - he’s that good - but if New York can’t run consistently, it'll face a lot of third-and-medium and invite pressure.
🦬 Bills (+1) vs. Ravens

🚨 Ravens vs. Bills projected score
Team | 1Q | 2Q | 3Q | 4Q | Final |
---|---|---|---|---|---|
Ravens | 7 | 3 | 3 | 7 | 20 |
Bills | 10 | 7 | 7 | 7 | 31 |
🔢 Bills projected stats
- Passing leader: Josh Allen – 23/34, 289 yards, 2 TD, 1 INT
- Rushing leader: James Cook – 15 rushes, 67 yards, 1 TD
- Receiving leader: Keon Coleman – 6 receptions, 82 yards, 1 TD
🔢 Ravens projected stats
- Passing leader: Lamar Jackson – 21/31, 238 yards, 1 TD; 9 rush, 54 yards
- Rushing leader: Derrick Henry – 18 rushes, 79 yards
- Receiving leader: Zay Flowers – 6 receptions, 71 yards
🔮 Ravens vs. Bills prediction
Buffalo gets the nod at home because Josh Allen’s weapons look deeper: Dalton Kincaid is a year better, James Cook is a clean outlet, and Keon Coleman adds size on the boundary. If the Bills protect well enough, their explosives and red-zone sequencing should carry.
Baltimore can absolutely trade haymakers - Lamar Jackson and Derrick Henry will create problems - but with Isaiah Likely expected out, more of the middle-of-the-field burden falls to Mark Andrews and Zay Flowers. Our sims tilt toward a couple of short-field opportunities for Buffalo and a late pull-away sequence.
🟢 Seahawks (+2.5) vs. 49ers

🚨 49ers vs. Seahawks projected score
Team | 1Q | 2Q | 3Q | 4Q | Final |
---|---|---|---|---|---|
49ers | 3 | 7 | 3 | 7 | 20 |
Seahawks | 7 | 7 | 3 | 7 | 24 |
🔢 Seahawks projected stats
- Passing leader: Sam Darnold – 22/33, 238 yards, 1 TD, 1 INT
- Rushing leader: Kenneth Walker III – 18 rushes, 86 yards, 1 TD
- Receiving leader: Cooper Kupp – 6 receptions, 78 yards, 1 TD
🔢 49ers projected stats
- Passing leader: Brock Purdy – 23/34, 252 yards, 1 TD, 1 INT
- Rushing leader: Christian McCaffrey – 19 rushes, 87 yards, 1 TD
- Receiving leader: George Kittle – 6 receptions, 68 yards, 1 TD
🔮 49ers vs. Seahawks prediction
This is a modest upset (Seattle has been a small home underdog on some boards), and the matchup lines up with what we want: a retooled Seattle roster with Sam Darnold steering a run-first plan and a healthy Kenneth Walker III, plus a legit chain-mover in Cooper Kupp alongside Jaxon Smith-Njigba. The 49ers still have stars, but they’ve turned over a lot of defensive pieces and are leaning on youth early, which raises variance on the road.
San Francisco can absolutely win this with Brock Purdy, Christian McCaffrey, and George Kittle if they control the edges and keep Seattle behind the sticks. My sims, though, show the Seahawks’ ground game setting the tone, Darnold staying on schedule off play-action, and their corners doing just enough against a WR group headlined by Jauan Jennings and Ricky Pearsall. One red-zone stop and a short field late are the swing factors to get us home.
💡 More NFL expert picks
- NFL picks against the spread Week 1
- NFL QB clutch player ratings Week 1
- NFL fantasy pickup player props Week 1
- NFL rookie player props Week 1
- NFL trends that matter Week 1
- NFL weather report Week 1
- NFL upset picks Week 1
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