49ers vs. Seahawks Week 13 NFL Picks: Seattle's Last Chance To Save Season

The Seattle Seahawks have had a massively disappointing year but can complete a season sweep of the NFC West rival San Francisco 49ers on Sunday from the Pacific Northwest. Read on for our 49ers-Seahawks picks.

Honestly, picking against the spread in Sunday's 49ers at Seahawks matchup is really about the lesser of two evils. The 49ers are playing much better football right now but likely will be missing two of their most important players. Seattle, meanwhile, is in a freefall and playing on a short week, but returns home a desperate team.

Seattle leads the all-time series 29-17, which includes a victory in an epic NFC Championship Game following the 2013 season.

Here are my picks and predictions for the NFL Week 13 matchup between the 49ers and Seahawks (odds via DraftKings; pick confidence based on a 1-to-5-star scale).

49ers vs. Seahawks Game Info

Date/Time: Sunday, Dec. 5, 4:25 p.m. ETTV: CBSLocation: Lumen Field, Seattle, WAWeather: Cloudy with 25% chance of rain.

49ers vs. Seahawks Odds Analysis

On the lookahead lines last Wednesday, this was a pick’em. Then the Niners looked good in beating Minnesota in Week 12 and the Seahawks looked awful again in a loss at Washington and now it's Niners -3.5. I don't think it will get bigger. It will mark only the second time in the past 10 years the Seahawks are home regular-season dogs in this series. The total opened as high as 47 and is down to 46. In the first meeting this season, it closed at 52.

49ers vs. Seahawks Picks

Seahawks +3.5 (-110) ???Under 46 (-110) ????

SEE ALSO: Colts vs. Texans Week 13 Picks

49ers vs. Seahawks Predictions

Seahawks +3.5 (-110)

The Seahawks were 2.5-point underdogs at Levi's Stadium in Week 4 and won 28-21 to avoid a 1-3 start and temporarily save their season - or so we thought. Quarterback Russell Wilson threw for two scores and rushed for one.

I take little from that result. However, I am going to back the Seahawks getting more than three points at home because they are in desperation mode at 3-8 and on a three-game skid. The playoffs probably are a pipe dream regardless but there will be no chance with another loss, which would clinch the franchise's first losing season since drafting Wilson. I do believe Wilson is playing elsewhere next season and also think coach Pete Carroll will not be on the sideline in 2022. There will be a lot of changes in the Pacific Northwest.

While Seattle being the home team and desperate are definitely reasons for my spread lean, the Niners being without star receiver Deebo Samuel - who is having an MVP-caliber season – and stud linebacker Fred Warner due to injury is another. Samuel and Warner were both banged up in the second half of the 49ers' Week 12 win over the Vikings.

Wilson is 16-4 straight up and 14-5-1 against the spread in his career against the Niners. San Francisco is 4-10 ATS in its last 14 as a favorite.

Under 46 (-110)

Have you seen Wilson and that Seattle offense since he returned from his finger injury? Zero points in Green Bay, 13 versus Arizona, and 15 on Monday in Washington, two of which came on a returned PAT by a nearly 300-pound defensive lineman.

Before the finger injury, Wilson was completing 72 percent of his passes at 9.6 yards per attempt with 10 touchdowns and one pick for a rating of 125.3, best in the NFL. In the three games since, he has a 56 completion percentage, 6.3 yards per attempt, two TDs, and one pick for a rating of 73.2. Seattle has averaged just 19:36 time of possession in those three games, the worst three-game span of any team this century. Granted, the Seahawks have little running game to speak of, but Wilson still has Tyler Lockett and DK Metcalf at wideout. Metcalf had just one catch Monday.

How much will the Niners miss the injured Samuel? The 2019 second-round pick has blown up with 56 catches for 1,006 yards and five scores. Coach Kyle Shanahan is also using him on jet sweeps, reverses, and the like as Samuel has rushed 25 times for 203 yards and five scores, which are the most rushing TDs by a receiver in a season in the Super Bowl era. Samuel is also the first wide receiver since 1970 to record a rushing touchdown in three consecutive games.

Jauan Jennings would get a much bigger role with Samuel out, though he has just seven catches on 12 targets. The loss of Warner will certainly hurt the Niners' defense, but I don't believe the Seahawks are capable of taking much advantage of it.

The Under is 16-2-1 in Seattle's past 19 regular-season games and 9-1-1 this year. The Under is 5-2 in the Niners' past seven versus the NFC West.

SEE ALSO: All picks and odds. Be sure to check out SportsbookReview.com’s community forums and betting tools.

49ers-Seahawks picks made 12/1/2021 at 6:13 p.m. ET