49ers vs. Rams Prediction Tonight: Thursday Night Football Odds & TNF Expert Picks
My 49ers vs. Rams prediction expects the home favorites to prevail tonight on Thursday Night Football (8:15 pm. ET, Prime Video) to kick off our NFL predictions for Week 5 from SoFi Stadium in Inglewood, Calif.
Los Angeles is nearly a 10-point favorite after several 49ers were ruled out for the matchup, including quarterback Brock Purdy.
Given that development, I'm breaking down my best NFL picks for this prime-time showdown, which includes taking the Over on Rams running back Kyren Williams' rushing attempts prop.
📊 49ers vs. Rams odds: Thursday Night Football
Latest Thursday Night Football odds update in real time.
📈 49ers vs. Rams odds update
Los Angeles is now a 9.5-point favorite at some of the best sports betting sites after opening at -2.5. It's unlikely that number lengthens further through the key number of 10, even given the 49ers' lengthy injury list.
🏈 49ers vs. Rams predictions: Thursday Night Football
NFL expert picks for Thursday Night Football; NFL odds subject to change.
- Game pick: Rams -5.5 (-122 via FanDuel) ⭐⭐⭐⭐
- Over/Under pick: Under 46.5 (-102 via FanDuel) ⭐⭐⭐⭐
- Player prop bet: Kyren Williams Over 16.5 carries (-111 via DraftKings) ⭐⭐⭐⭐
✅ 49ers vs. Rams expert pick for TNF
Track the latest NFL scores for line movement and matchup info.
⬇️ Rams -5.5 (-122) ⭐⭐⭐⭐
I hope you followed my against-the-spread pick in our 49ers vs. Rams early prediction, as that -3 spread is long gone. The injury issues surrounding several key injured 49ers, including Pearsall, Jennings, and Purdy, has increased the spread to -7.
A presumed Mac Jones-led offense already devoid of tight end George Kittle won't cause any sleepless nights for a Rams defense that has the eighth-best EPA per play.
With Jones at the helm, the 49ers' offense struggled to produce against an average Arizona Cardinals defense, scoring their only touchdown in the fourth quarter.
Jones isn't far removed from a recent knee injury, and he'll be going up against a Rams defense ranked ninth against the pass. On the opposing side, Rams QB Matthew Stafford will look forward to facing a 49ers defense that doesn't have Nick Bosa at its disposal.
FanDuel is the only sportsbook offering -5.5 - and it might not last long.
💰 49ers vs. Rams player prop bet for TNF
Our NFL player prop odds tool shows the best odds for every market across legal sportsbooks in your area.
⬆️ Kyren Williams Over 16.5 rushing attempts (-111) ⭐⭐⭐⭐
Such is the uncertainty surrounding who will or won't play, there are currently no 49ers' receiver props available at the best sports betting apps. Keep your eye on that market in the lead-up to kickoff, as running back Christian McCaffrey should receive an increased target share in the passing game.
It's on to Kyren Williams, who I expect to be a focal point of the Rams offense to an even higher degree than usual.
The Rams will want to control the clock and tempo. I believe Los Angeles will be protecting a decent lead in the fourth quarter, creating ripe conditions for an increased number of carries. He hit the Over on this total in three of four games, averaging 17 carries.
DraftKings' -111 odds present the best value, with BetMGM (-135) providing the worst possible return. A winning $10 bet at DraftKings would yield a profit of $9.01. Matt Jacob backs two other Rams and one 49er with his 49ers vs. Rams player props for TNF.
💡 More Monday Night Football picks
🚑 49ers vs. Rams injury report
📺 How to watch Thursday Night Football
- Date: Thursday, Oct. 2
- Kickoff: 8:15 p.m. ET
- Where: SoFi Stadium (Inglewood, Calif.)
- TV: Prime Video
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