49ers vs. Colts Same-Game Parlay for Monday Night Football: Tonight's SGP Picks & Odds
Our 49ers vs. Colts same-game parlay for tonight's NFL Week 16 matchup anticipates Philip Rivers' magic wearing off quickly.
The 49ers can stymie the veteran quarterback, and their offense should capitalize on a generous Indianapolis secondary in a lopsided win. Tonight's action from Lucas Oil Stadium in Indianapolis gets underway at 8:15 p.m. ET (ABC/ESPN). The 49ers are a 5.5-point betting favorite as we present our NFL Week 16 predictions.
🏈 49ers vs. Colts same-game parlay for Monday Night Football
See the latest NFL odds and our experts' NFL picks for every game this season.
| Parlay bet | Odds (DraftKings) | Confidence |
|---|---|---|
| 49ers -5.5 | -110 | ⭐⭐⭐⭐⭐ |
| George Kittle Over 67.5 receiving yards | -113 | ⭐⭐⭐⭐ |
| Jauan Jennings anytime TD scorer | +140 | ⭐⭐⭐⭐ |
Best SGP odds: +675 via DraftKings ($10 to win $67.50)
🚀 Best Monday Night Football SGP & parlay picks
See all of our NFL same-game parlay bets for Monday Night Football and more.
49ers -5.5 (-110) ⭐⭐⭐⭐⭐
Though we saw the Philip Rivers-led Colts manage to play the Seahawks down to the wire in Rivers’ first game in five years, I’m trusting the San Francisco coaching staff to use that game film to identify ways to force the Colts away from Rivers’ comfort zone.
I expect Indy to struggle to put points on the board. San Francisco has the NFL’s third-best ATS record on the road this season, going 6-2 ATS in away games.
George Kittle Over 67.5 receiving yards (-113) ⭐⭐⭐⭐
The Indianapolis defense is generous through the air (allowing 247.6 passing yards per game, ranked 30th), and that trend includes the tight end position. Tight ends have logged 928 yards in 14 games against the Colts, fifth-most on a per game basis in the league this season.
George Kittle has produced 67 or more receiving yards in five straight games leading into Monday night. Rick Pearsall has been ruled out, leading other 49ers pass-catchers to pick up the slack. One of our Phil Wood's 49ers vs. Colts player props expects a big game from Kittle, too.
Sean Tomlinson is featuring Kittle too in his first touchdown scorer predictions for Monday Night Football
Jauan Jennings anytime TD scorer (+140) ⭐⭐⭐⭐
Jauan Jennings’ +140 anytime TD scorer odds from DraftKings come with a 41.67% implied probability that vastly undersells his recent production.
Jennings has scored a touchdown in five of his past six games, scoring six total touchdowns in that span. The Colts have a strong red zone defense but still permit 1.3 passing touchdowns per game. Esten McLaren backs this pick with his anytime touchdown scorer predictions.
And if you'd prefer a different touchdown scorer play, our 49ers vs. Colts prediction has you taken care of on that front.
💡 More NFL predictions
Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for every game this season.
🤑 Monday Night Football betting splits: 49ers vs. Colts
Betting insights via BetMGM.
| Bet type | % of bets | % of handle |
|---|---|---|
| 49ers ML (-250) | 46% | 77% |
| Colts ML (+200) | 54% | 23% |
| 49ers - 5.5 | 66% | 66% |
| Colts +5.5 | 34% | 34% |
| Over 46 | 53% | 24% |
| Under 46 | 47% | 76% |
📺 How to watch Monday Night Football: 49ers vs. Colts
- Date: Monday, Dec. 22
- Kickoff: 8:15 p.m. ET
- Location: Lucas Oil Stadium (Indianapolis)
- TV: ABC/ESPN
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