49ers vs. Colts Predictions for Monday Night Football | MNF Odds & Picks Tonight
The Philip Rivers experiment continues for a second straight week as I share my best 49ers vs. Colts predictions for Monday Night Football.
Kickoff from Lucas Oil Stadium in Indianapolis is slated for 8:15 p.m. ET (ESPN), with San Francisco entering as a 6-point betting favorite. My NFL Week 16 predictions skip the point spread and instead focus on buying low on the Colts’ offense, which should help the Over (46.5) cash.
🏈 49ers vs. Colts prediction: Monday Night Football
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| Best bets | Odds | Confidence |
|---|---|---|
| Over 46.5 | -102 via DraftKings | ⭐⭐⭐⭐ |
| Christian McCaffrey 1H TD | +130 via DraftKings | ⭐⭐⭐ |
Over 46.5 (-102) ⭐⭐⭐⭐
San Francisco has played some of its best offensive football during a four-game winning streak.
Since Week 11, when quarterback Brock Purdy returned from injury, the 49ers rank fourth in points per game (31.0), second in Total QBR, first in third-down rate, and sixth in Offensive Efficiency. They've been excellent on the road ATS this season, easily putting up points on their way to a 6-2 ATS record away from home - a key factor in our 49ers vs. Colts same-game parlay.
Indianapolis has averaged 17.8 points per game in that span while producing its four lowest yardage totals of the season. But opposing quarterbacks average more than 23 completions per game against San Francisco, so Rivers should fare better than he did in his NFL return last week. Esten McLaren has three anytime touchdown scorer predictions for what is expected to be a higher-scoring game.
DraftKings is the only one of our best sports betting sites with better than a -110 price (52.38% implied odds). Its -102 odds would net $9.80 in profit on a $10 wager if the Over cashes.
Score prediction: 49ers 27, Colts 24
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🙌 Best 49ers vs. Colts TD pick
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Christian McCaffrey, RB, 49ers: To score a first-half touchdown (+130) ⭐⭐⭐
Brock Purdy’s return from injury has opened up San Francisco’s running game, as defenses must honor his second-ranked Total QBR since Week 11.
In those four games, San Francisco has rushed for six touchdowns and averaged 117.8 yards per game on the ground. That is the same amount of rushing touchdowns the team had through the first 10 weeks, when it averaged 94.8 rushing yards per game.
Backing McCaffrey to score in the first half is a great way to mitigate his steep anytime touchdown odds that carry as high as a 69.23% implied probability based on a market-high -225 price.
Our Philip Wood targets Michael Pittman Jr. to reach the end zone instead as part of his best 49ers vs. Colts player props. And Sean Tomlinson is eyeing another Niners pass-catcher in his first touchdown scorer predictions for Monday Night Football.
Best prop bet: Christian McCaffrey to score a first-half touchdown (+130 via DraftKings)
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📈 49ers vs. Colts betting trends
| 49ers | Statistic | Colts |
|---|---|---|
| 10-4 | W-L record | 8-6 |
| 8-5-1 | ATS record | 9-5 |
| 8-5-1 | O/U record | 7-7 |
| 5.50 | Yards per play | 6.13 |
| 5.68 | Yards allowed per play | 5.45 |
| -5 | Turnover margin | +2 |
| 4-1 | Last 5 games | 1-4 |
| W, 37-24 vs. Titans | Previous result | L, 18-16 vs. Seahawks |
🚑 49ers vs. Colts injury report
🤑 Monday Night Football betting splits: 49ers vs. Colts
Betting insights via BetMGM.
| Bet type | % of bets | % of handle |
|---|---|---|
| 49ers ML (-250) | 46% | 77% |
| Colts ML (+200) | 54% | 23% |
| 49ers - 5.5 | 66% | 66% |
| Colts +5.5 | 34% | 34% |
| Over 46 | 53% | 24% |
| Under 46 | 47% | 76% |
📺 How to watch Monday Night Football: 49ers vs. Colts
- Date: Monday, Dec. 22
- Kickoff: 8:15 p.m. ET
- Location: Lucas Oil Stadium (Indianapolis)
- TV: ESPN
💡 Monday Night Football expert picks
- 49ers vs. Colts prediction
- 49ers vs. Colts player props
- 49ers vs. Colts anytime touchdown scorer predictions
- 49ers vs. Colts first touchdown scorer predictions
- 49ers vs. Colts same-game parlay
- Brock Purdy player props
- Philip Rivers player props
- Jonathan Taylor player props
- 49ers vs. Colts expert picks
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