49ers vs. Colts Player Props for Monday Night Football: NFL Week 16

My best 49ers vs. Colts player props for Monday Night Football feature George Kittle, Philip Rivers, and Michael Pittman Jr.

Kickoff is set for 8:15 p.m. ET from Lucas Oil Stadium in Indianapolis (ESPN/ABC), with the 49ers favored by 5.5. My NFL predictions for Week 16 expect Rivers to have more success this week in a better matchup and Kittle to exploit one of the worst defenses against tight ends.

🏈 49ers vs. Colts player prop bets: Monday Night Football

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George Kittle Over 66.5 receiving yards (-114) ⭐⭐⭐⭐

George Kittle has at least 67 receiving yards in five consecutive games. The Colts are allowing the second-most passing yards per game, and they’re allowing 66.3 yards per game to tight ends, which is the fifth-most in the league.

Kittle also has at least four receptions in all but one game this season, and he’s been targeted at least nine times in three of his last five games.

DraftKings’ price of -114 implies a 53.27% chance that this Over hits. A $10 bet would profit $8.77.

🔥 More 49ers vs. Colts prop picks

Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for every game in Week 16.

Philip Rivers Over 157.5 passing yards (-114) ⭐⭐⭐⭐

Philip Rivers threw for just 120 yards last week, averaging 4.4 yards per attempt. But he was also going against a Seahawks defense that is allowing the second-fewest yards per attempt. The 49ers are allowing 227.6 passing yards per game, which ranks 22nd in the league.

Rivers threw 27 passes last week in a game his team led almost the entirety of. I expect more attempts and more yards in a better matchup where his team is expected to be trailing.

FanDuel’s price implies a 53.27% chance this Over hits. A $10 bet would profit $8.77.

Michael Pittman Jr. to score a touchdown (+380) ⭐⭐⭐

Michael Pittman Jr. has scored seven times this season, but he’s only scored once in his last six games. That said, he was tied for the second-most Colts receptions last week (three), and he was targeted five times.

The 49ers have allowed 25 passing touchdowns, which is tied for the sixth-most in the league. Though Pittman didn’t do much last week, he had nearly 20% of passes thrown his way, and the 49ers are a much better matchup than the Seahawks for receivers.

There could be plenty of scoring tonight, as our Mike Spector backs the Over in his 49ers vs. Colts predictions.

DraftKings’ price of +380 implies a 20.83% chance that Pittman scores. A $10 bet would profit $38.

📺 How to watch Monday Night Football: 49ers vs. Colts

• Date: Monday, Dec. 22
• Kickoff: 8:15 p.m. ET
• Location: Lucas Oil Stadium (Indianapolis)
• TV: ESPN/ABC