49ers vs. Browns Player Props: Best Bets & TD Picks for NFL Week 13
Last Updated: November 30, 2025 5:00 AM EST • 3 minute read X Social Google News Link
My best 49ers vs. Browns player props focus on Shedeur Sanders, Christian McCaffrey, and Jauan Jennings ahead of Sunday’s 1 p.m. ET (CBS) at Huntington Bank Field in Cleveland. The 49ers are favored by 4.5.
Below I highlight my expectations for Sanders against a weak pass defense and McCaffrey and Jennings against one of the league’s best defensive units. For more coverage of this game, check out our NFL Week 13 predictions.
✅ 49ers vs. Browns player prop bets
See all of our experts' NFL picks for Week 13.
💵 Best 49ers vs. Browns player prop bets
- Shedeur Sanders player prop: Under 155.5 passing yards (-114 via FanDuel) ⭐⭐⭐⭐
- Christian McCaffrey player prop: Over 67.5 rushing yards (-112 via DraftKings) ⭐⭐⭐⭐
- Jauan Jennings TD pick: Score a touchdown (+320 via bet365) ⭐⭐⭐⭐
💰 Best 49ers vs. Browns player props
⬇️ Shedeur Sanders player prop: Under 155.5 passing yards (-114) ⭐⭐⭐⭐
Sanders threw for 209 yards in his first NFL start, yet oddsmakers only have his total set at 155.5 yards for Sunday. This is despite the 49ers allowing 241.8 passing yards per game, 23.5 more than Sanders’ first opponent, the Raiders.
While Sanders was okay in his first start, his final stat line is greatly inflated by a 66-yard screen pass that resulted in a Dylan Sampson touchdown. Sanders has completed just 15 of his 36 passes, and if he needs to rely too heavily on screens, I don’t like his chances of hitting this Over against a team that has held five quarterbacks to fewer than 200 yards this season.
BetMGM has this total set as low as 148.5 FanDuel’s price of -114 implies a 53.27% chance that Sanders throws for fewer than 155.5 yards. A $10 bet would profit $8.77.
⬆️ Christian McCaffrey player prop: Over 67.5 rushing yards (-112) ⭐⭐⭐⭐
The Browns’ rush defense has progressively gotten worse this season, and the unit now ranks 11th in the league, allowing 102.3 rushing yards per game. The Browns have allowed a 75-yard rusher in four of their last five games.
When it comes to running the ball, McCaffrey got off to a slow start, topping 60 yards in just one of his first six games. However, since then, he’s topped 80 yards in four of six contests, including each of his last two. And while McCaffrey is averaging just 3.7 yards per carry this season, he’s also averaging 18 carries per game, and he had 24 last week.
DraftKings’ price of -112 implies a 52.83% chance that this Over hits. A $10 bet would profit $8.93.
6️⃣ Best 49ers vs. Browns touchdown scorer bet
🔥 Jauan Jennings TD pick: Score a touchdown (+320) ⭐⭐⭐⭐
The Browns have the second-ranked pass defense in the league, allowing just 170.7 passing yards per game. However, they’ve allowed 17 passing touchdowns, which is tied for the 16th-most this season.
Jennings has scored in three of his last four games, as he’s compiled at least four catches in six consecutive weeks. He’s tied for the third-most touchdown receptions on the team behind only McCaffrey and George Kittle. The Browns do a good job of covering tight ends, giving up just five touchdowns to the position this season, so it really doesn’t make sense that Jennings’ price is so much worse than Kittle’s (+220).
The bet365 price of +320 implies a 23.81% chance that Jennings scores. A $10 bet would profit $32.
💡 More Week 13 predictions
Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for every game in Week 13.
📊 49ers vs. Browns anytime touchdown scorer odds
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📺 How to watch 49ers vs. Browns
- Date: Sunday, Nov. 30
- Kickoff: 1 p.m. ET
- Location: Huntington Bank Field (Cleveland)
- TV: CBS
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