Louisville vs. Tennessee Prediction & Odds: College Basketball Picks Tonight (Dec. 16)
Last Updated: December 16, 2025 11:01 AM EST • 2 minute read X Social Google News Link
My Louisville vs. Tennessee prediction is counting on the No. 20 Volunteers to end their three-game skid when they host the No. 11 Cardinals. Tipoff from Thompson-Boling Arena at Food City Center in Knoxville, Tenn., is set for 7 p.m. ET (ESPN).
The Volunteers (7-3) are a 2.5-point betting favorite after the Cardinals (9-1) opened as a short road favorite. I’d suggest following the market on this one.
🏀 Louisville vs. Tennessee prediction
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Tennessee ML (-130) ⭐⭐⭐⭐
Tennessee is now laying as much as 2.5 points after opening as a short home underdog. Bettors believe the Vols can end their three-game slide in their first home contest since Nov. 20.
That’s not a bad assumption, considering Louisville lost by nine to Arkansas in its only other road matchup. The Cardinals have the highest 3-point rate (55.4%) in the nation, while Tennessee is holding opponents to below 30% from long range.
Evan Miya’s projections suggest the Volunteers have a 57.8% win probability. The -130 price tag at DraftKings has an implied probability of 56.52%, indicating slight value relative to BetMGMs -140 price tag.
Score prediction: Tennessee 80, Louisville 77
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Nate Ament, Forward, Tennessee: Over 14.5 points (-125) ⭐⭐⭐⭐
Tennessee forward Nate Ament will be tasked with ending a three-game skid. He’s averaging 16.3 points per game this season, clearing this scoring prop in six of his 10 contests.
Ament has struggled in back-to-back matchups, shooting 6-of-24 from the floor. But I’m betting on a bounce-back performance at home, as he averaged 18.8 points in his first five outings at Thompson-Boling Arena.
This Over is trading as high as -135 at DraftKings, suggesting a slight discount at FanDuel for an $8 win on a $10 wager.
📊 Louisville vs. Tennessee odds
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📺 How to watch Louisville vs. Tennessee
- Date: Tuesday, Dec. 16
- Tipoff: 7 p.m. ET
- Location: Thompson-Boling Arena at Food City Arena (Knoxville, Tenn.)
- TV: ESPN
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