Louisville vs. Duke Prediction, Picks & Odds: College Basketball Picks Today (Jan. 26)
In the first of two top-25 matchups in college basketball today, my Louisville vs. Duke prediction backs Duke's freshman star to carry the Blue Devils to another win over the Cardinals.
Led by Cameron Boozer, Duke is a 7.5-point betting favorite for tonight's 7 p.m. ET (ESPN) tip from Cameron Indoor Stadium in Durham, N.C. Don't miss our breakdown of the other top-25 game tonight, with our Arizona vs. BYU prediction.
🏀 Louisville vs. Duke predictions
See our experts' college basketball picks based on the latest college basketball odds.
| Prediction | Best odds | Confidence |
|---|---|---|
| Duke -7.5 | -105 via DraftKings | ⭐⭐⭐⭐ |
| Under 157.5 | -108 via Caesars | ⭐⭐⭐⭐ |
| Cameron Boozer Over 24.5 points | +102 via bet365 | ⭐⭐⭐ |
💰 Louisville vs. Duke best bet: Duke -7.5 (-105) ⭐⭐⭐⭐
Check out all of our college basketball analysis and expert predictions this season.
The first time these two played, Duke covered as a 1.5-point favorite on the road and won by 11. While Louisville does have Mikel Brown Jr. this time around, the Blue Devils still have a clear advantage with an offense ranked No. 5 in adjusted efficiency.
Louisville's defense has been shaky, sitting No. 34 in adjusted efficiency and allowing 83.5 PPG to ranked opponents. In those games, the Cardinals are 2-4 ATS.
With a top-five defense to slow Louisville's explosive attack, Duke should win decisively again and continue to shorten its March Madness odds.
Score prediction: Duke 83, Louisville 73
🔥 Best Louisville vs. Duke player prop: Cameron Boozer, Duke Over 24.5 points (+102) ⭐⭐⭐
This freshman class is insane, and no player has been more dominant than Boozer. The Wooden Award odds favorite leads the country in PPG (23.7) and has shown no signs of slowing down.
Boozer is coming off back-to-back 30-plus point games, and he's averaging 24.4 PPG in ACC play. He's just three weeks removed from dropping 27 on Louisville in his most efficient outing of the season.
The last time these two teams played, Boozer shot 10-for-12 (83.3%) from the floor and hit three 3-pointers on 75% shooting.
📊 Live Louisville vs. Duke odds
📈 Louisville vs. Duke betting trends
| Louisville | Statistic | Duke |
|---|---|---|
| 14-5 | W-L record | 18-1 |
| 10-9 | ATS record | 11-8 |
| 8-11 | O/U record | 7-12 |
| 3-2 | Last 5 games | 5-0 |
📺 How to watch Louisville vs. Duke
- Date: Monday, Jan. 26
- Tipoff: 7 p.m. ET
- Location: Cameron Indoor Stadium (Durham, N.C.)
- TV: ESPN
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