Duke vs. Louisville Predictions & Odds Tonight | College Basketball Picks for Jan. 6
My Duke vs. Louisville predictions expect the Blue Devils to pick up a key road win in this conference showdown.
Tipoff from the KFC Yum! Center in Louisville, Ky., is set for 7 p.m. ET (ESPN). No. 2 Louisville (11-3, 1-1 ACC) is a -115 betting favorite over No. 6 Duke (13-1, 2-0). However, the Cardinals haven’t been the same team without Mikel Brown Jr., who will miss his fifth straight game tonight.
🏀 Duke vs. Louisville predictions
See our experts' college basketball picks based on the latest college basketball odds.
| Predictions | Best odds | Confidence |
|---|---|---|
| Duke ML | -105 via DraftKings | ⭐⭐⭐⭐ |
| Cameron Boozer Under 24.5 points | -120 via BetMGM | ⭐⭐⭐ |
💰 Duke vs. Louisville best bet
Want more college basketball betting advice? Check out all of our college basketball analysis and expert predictions this season.
Duke ML (-105) ⭐⭐⭐⭐
Louisville will be without its five-star freshman point guard for the fifth straight game, which changes the handicap completely. The Cardinals are 2-2 without Brown, losing to Tennessee (No. 16 on KenPom) and Stanford (No. 81).
Louisville has ranked 36th in adjusted offensive efficiency and 58th in adjusted defensive efficiency in the four games without Brown, according to Bart Torvik. Duke, meanwhile, ranks in the top 16 in both and is ninth overall on KenPom.
Basically, the Blue Devils are a much better team in this spot. I’ll pay the short moneyline price to win $9.52 on a $10 wager at DraftKings.
Score prediction: Duke 82, Louisville 78
🔥 Best Duke vs. Louisville player prop
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Cameron Boozer, F, Duke: Under 24.5 points (-120) ⭐⭐⭐
Despite my belief in Duke, I’ll fade Cameron Boozer in a road matchup. He hasn’t scored more than 18 points in any of his previous three road contests, which have come against Florida State (17 points), Michigan State (18), and Army (15).
Louisville has done an excellent job at defending the interior this year. The Cardinals rank seventh in 2-point defense and 14th in average 2-point attempt defense, according to KenPom.
At -120, a $10 bet earns a profit of $8.33. Our Mike Spector targets a different Blue Devil as part of his college basketball best bets today.
📊 Live Duke vs. Louisville odds
🤑 Duke vs. Louisville betting splits
Betting insights via BetMGM.
| Bet type | % of bets | % of handle |
|---|---|---|
| Duke ML (-110) | 66% | 72% |
| Louisville ML (-110) | 34% | 28% |
| Duke +1.5 | 61% | 56% |
| Louisville -1.5 | 39% | 44% |
| Over 161.5 | 72% | 82% |
| Under 161.5 | 28% | 18% |
📺 How to watch Duke vs. Louisville
- Date: Tuesday, Jan. 6
- Tipoff: 7 p.m. ET
- Location: KFC Yum! Center (Louisville, Ky.)
- TV: ESPN
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