DePaul vs. Creighton Prediction, Odds & Score Picks Tonight: Big East Quarterfinal Best Bets

DePaul survived another day by beating Georgetown, but life in the Big East tournament isn't expected to get any easier tonight when the Blue Demons face Creighton.

This game is set to get underway at 7 p.m. ET (FS1) from Madison Square Garden, and our DePaul vs. Creighton prediction, odds, and expert picks expect the underdogs to struggle to replicate their success from a game ago.

💰 DePaul vs. Creighton predictions, expert picks & best bets: Big East quarterfinal

Here are my best DePaul vs. Creighton predictions, expert picks, and best bets today for Big East quarterfinal with my pick confidence based on a 1-to-5-star scale. Be sure to check out the rest of our college basketball picks along with our guide on how to bet on college basketball.

• Against the spread pick: Creighton -11.5 (-110 via BetMGM) vs. DePaul ⭐⭐⭐⭐
• My best Over/Under pick: Under 144.5 (-110 via bet365) ⭐⭐⭐⭐
• Exact score prediction: Creighton 76, DePaul 63 (+24000 via FanDuel)

👉 Check out our latest March Madness projections with our SBR Bracketology ahead of the NCAA Tournament!

🏀 DePaul vs. Creighton ATS prediction & best Over/Under pick

Here's why I'm betting on Creighton to cover the spread (-11.5) while targeting Under 144.5 as my best Over/Under pick for today:

✅ Creighton to cover the spread (-11.5) ⭐⭐⭐⭐

During the regular season, Creighton defeated DePaul by margins of 24 and 10 points. Creighton ranks inside the KenPom top 50 in both adjusted offensive and defensive efficiency and is the far more sound team, while DePaul slots in 115 or lower in both categories.

The Bluejays are strong on the defensive glass and should smother second-chance opportunities away from a DePaul side that ranks near the bottom of Division 1 in offensive rebounds. Since DePaul isn’t particularly efficient with their first opportunities on the offensive end, it’s hard to figure where the Blue Demons find a way to keep this one close.

Creighton is 18-11-2 ATS on the year. It’s a mismatch, and Creighton should cruise to their third double-digit margin of victory over DePaul.

📊 Best odds: -110 via BetMGM (bet $10 to win $9.09)

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🔥 Under 144.5 ⭐⭐⭐⭐

Both games played between DePaul and Creighton have landed below this game total, with final scores totaling 122 and 140 points in those respective matchups.

With neither side deploying a particularly quick pace - both teams rank outside the top 150 in adjusted tempo - it would require an overly efficient effort offensively to see this game getting Over.

While DePaul has upped its scoring profile in a number of recent games to see several scores clearing this total, the Blue Demons just haven’t demonstrated the ability to pull their weight in the scoring against this particular opponent - or good teams, in general.

📊 Best odds: -110 via bet365 (bet $10 to win $9.09)

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🎯 Expert DePaul vs. Creighton score prediction

🔮 Expert score prediction: Creighton 76, DePaul 63

DePaul’s offensive outbursts against mediocre teams like Butler, Providence and Georgetown recently have simply not been an element that has translated for the Blue Demons against quality opponents. Against Marquette, Villanova and St. John’s in recent weeks, the Blue Demons have failed to crack even 60 points.

We think DePaul can sneak over that total, as it did in its last matchup against Creighton, but finding any momentum toward scoring with the Bluejays just seems like an unlikely endeavor given DePaul’s consistent struggles against quality foes.

DePaul’s last five games against teams on the bubble or above have all resulted in double-digit defeats.

📊 Best odds: +24000 via FanDuel (bet $10 to win $2,400)

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📊 Live DePaul vs. Creighton odds & latest betting splits

Here are the latest odds for DePaul vs. Creighton, which update live in real time. You can also check out our NEW college basketball player prop odds tool for the latest college basketball odds on any market across legal sportsbooks in your region.

🔢 DePaul vs. Creighton opening odds

Here's a look at the opening odds for DePaul vs. Creighton according to BetMGM.

• Spread: DePaul +11.5 (-110) | Creighton -11.5 (-110)
• Moneyline: DePaul +500 | Creighton -700
• Over/Under: Over 145.5 (-105) | Under 145.5 (-115)

🏆 Who will win DePaul vs. Creighton?

As of Thursday morning, Creighton is favored by 11.5 points to beat DePaul with moneyline odds of -800 at BetMGM, which suggest a 88.89% win probability for the Bluejays. We're predicting a 76-63 win for Creighton as our final score projection.

📺 How to watch DePaul vs. Creighton tonight

📅 Date: Thursday, March 13, 2025
🕗 Time: 7 p.m. ET
📍 Location: Madison Square Garden (New York)
📺 TV: FS1
💻 Streaming: FOX Sports App

❓DePaul vs. Creighton FAQs

Who's favored to win the Big East Conference tournament?

St. John’s is the favorite to win the Big East tournament, with odds of +125 at FanDuel.

Who is favored to win DePaul vs. Creighton?

Creighton is favored to beat DePaul, with moneyline odds of -650 at Caesars, equating to an implied win probability of 86.67%. 

What are the betting odds for DePaul vs. Creighton?

The spread is Creighton -11.5 (-110) | Creighton +11.5 (-110), with a total of 144.5 points (-110).

What will be the final score of DePaul vs. Creighton?

We're predicting a final score of Creighton 76, DePaul 63 entering tonight's matchup at Madison Square Garden.

What time is DePaul vs. Creighton tonight?

Tip-off is scheduled for tonight at 7 pm. ET.

⛹️ Best college basketball betting sites

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