Yankees vs. Astros Prediction, Odds & Expert Picks: MLB Best Bets for Sept. 3
The Houston Astros draw a scuffling pitcher for tonight’s matchup with the New York Yankees, something I’m looking to capitalize on in my Yankees vs. Astros prediction. First pitch from Daikin Park in Houston is set for 8:10 p.m. ET (Prime Video, MLB Network), with the Astros lined as a +110 moneyline underdog.
My MLB picks like Astros star Jose Altuve to continue his mastery of New York, and I’m backing one of his player props to reflect that. Our Gabe Henderson likes a different player at the plate in his home run predictions today.
⚾ Yankees vs. Astros expert picks & predictions
MLB expert picks made Wednesday; odds subject to change.
- Moneyline pick: Astros (+110 via BetMGM) ⭐⭐⭐⭐
- Run line pick: Astros +1.5 (-146 via FanDuel) ⭐⭐⭐
- Over/Under pick: Over 9 (-105 via BetMGM) ⭐⭐⭐
📝 Yankees vs. Astros preview & best bet
Track the latest MLB scores for line movement and matchup info.
🔥 Astros to win (+110) ⭐⭐⭐⭐
The Yankees got the better of the Astros in the series opener, picking up a 7-1 victory on Tuesday.
The Astros will look to get some revenge as they take on Yankees right-hander Will Warren. Warren hasn’t found much success pitching on the road in 2025, posting a 2-2 record with a 5.58 ERA and a 1.61 WHIP in 59 2/3 innings across 14 starts. Warren has been good as of late, with a 2.68 ERA over his last seven starts. However, his strikeout rate has fallen, and he has a 1.30 WHIP over 37 innings over that span. I think he’s a bit vulnerable heading into a matchup against an Astros lineup that features several quality hitters.
The Astros are 26-19 (57.8%) in 45 games where they’ve been the underdogs this season. Despite posting mediocre offensive numbers at home, the Astros are still 42-31 at Daikin Park in 2025.
BetMGM offers the Astros on the moneyline at +110 odds, which nets out a $11 profit on a $10 bet. The +110 odds have an implied probability of 47.62%. I love the opportunity to have a first-place team at home against a pitcher who has struggled to find much success pitching on the road.
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💰 Best Yankees vs. Astros player prop bet
Our MLB player prop odds tool shows the best odds for every market across legal sportsbooks in your area.
⬆️ Jose Altuve Over 0.5 RBIs (+190) ⭐⭐⭐
Jose Altuve has tormented Yankees pitching yet again in 2025, hitting .400 with a 1.367 OPS, two home runs, four RBIs, and five runs scored in four games.
Altuve is hitting just .213 with a .611 OPS over his last 15 games. He went hitless in the series opener against the Yankees, but there’s no denying that he historically seems to rise to the occasion against one of Houston’s biggest rivals.
A $10 bet on Altuve to drive in a run nets out a profit of $19 at FanDuel. The +190 odds have an implied probability of 34.48%.
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📊 Yankees vs. Astros odds: Sept. 3
MLB odds update live in real time.
📈 Yankees vs. Astros betting odds analysis
New York opened as -130 favorites against the Astros. The line has stayed relatively stable, with the Yankees ranging from -126 to -135 as a favorite on the moneyline as of Wednesday morning.
🔢 Yankees vs. Astros stats
Season stats courtesy of baseball-reference.com.
| Yankees (77-61) | Statistic (per game) | Astros (76-63) |
|---|---|---|
| 5.26 | Runs | 4.18 |
| 8.50 | Hits | 8.52 |
| .250 | AVG | .252 |
| .457 | SLG | .400 |
| .788 | OPS | .718 |
| 3.90 | ERA | 3.84 |
| 9.06 | K/9 | 9.58 |
| 3.52 | BB/9 | 3.15 |
| 1.09 | HR/9 | 1.22 |
🚑 Yankees vs. Astros injuries
📺 Yankees vs. Astros game info
- When: Wednesday, Sept. 3
- First pitch: 8:10 p.m. ET
- Where: Daikin Park (Houston)
- How to watch: Prime Video, MLB Network
💡 Expert MLB predictions today
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❓ Yankees vs. Astros FAQs
Who is favored to win Yankees vs. Astros?
The Yankees are a -130 favorite to defeat the Astros on the road on Wednesday.
What is the run line for Yankees vs. Astros?
New York is a -1.5 run line favorite against Houston in Wednesday’s matchup.
What is the Over/Under for Yankees vs. Astros?
The total for Wednesday’s game between the Yankees and Astros is 9.
What are the best bets for Yankees vs. Astros?
My best bets for Wednesday’s Yankees vs. Astros game are the Houston moneyline (+110) and Jose Altuve Over 0.5 RBIs (+190).
When is the Yankees vs. Astros game?
First pitch is set for 8:10 p.m. ET on Wednesday at Daikin Park.
How do baseball odds work?
When betting on MLB, the run line shows how many runs the favorite needs to win by in order to cash the bet. For example, a favorite of -1.5 must win by two or more runs to cover the run line, while an underdog at +1.5 must win outright or lose by one run to cover the run line.
Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total of runs will be higher or lower than the set number.
You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.
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