Royals vs. Tigers Prediction, Odds & Best Bets: Detroit's Dominance Following Off-Days to Continue

The Tigers are heavily favored against the rival Royals on Friday night.

Mike Spector

Last Updated: August 22, 2025 9:11 AM EDT • 4 minute read

Royals vs. Tigers Prediction, Odds & Best Bets: Friday, Aug. 22 — Pictured: Detroit Tigers pitcher Casey Mize (12) is crucial to my Royals vs. Tigers prediction. Photo by Junfu Han / USA TODAY NETWORK via Imagn Images.

I'm breaking down this clash of the top two teams in the AL Central with our Royals vs. Tigers prediction. The Kansas City Royals and Detroit Tigers have six head-to-head matchups remaining this season, and they play the first of those six at Comerica Park tonight, with first pitch scheduled for 7:10 p.m. ET (Apple TV+).

The Tigers are -160 moneyline favorites across our top sports betting sites. But even in an underdog role, my Royals vs. Tigers best bets expect a Kansas City All-Star to continue terrorizing opposing pitchers.

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💰 Royals vs. Tigers prediction & best bet

✅ Royals vs. Tigers prediction: Tigers to win (-155 via bet365)

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Kansas City got back into the win column after having its five-game winning streak snapped and losing just its second game in the last 10 overall. But Detroit has Casey Mize pitching tonight, which has meant nothing but wins lately, and it's why I am backing the Tigers' moneyline odds with my Royals vs. Tigers prediction.

The Tigers are 4-0 in Mize’s last four starts and 8-2 in his last 10. The team has also covered the runline in both of his starts against the Royals this year with a pair of two-run victories and even overcame his shortest outing of the season (3 1/3 innings) to that point.

Detroit is 5-2 in the head-to-head series thus far, and its 10-2 record following off-days are some of the biggest reasons for this Royals vs. Tigers best bet.

Most of our top sports betting apps have the Tigers at -160 moneyline odds or higher, so I am headed to bet365 for the best price.

📊 Live Royals vs. Tigers odds: Friday, 7:10 p.m. ET

💰 Best Royals vs. Tigers player prop

✅ Best Royals vs. Tigers player prop: Bobby Witt Jr. Over 0.5 runs (+100 via DraftKings)

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With all the talk of the American League MVP race being neck-and-neck between Aaron Judge and Cal Raleigh, Bobby Witt Jr. is quietly third in the AL in WAR (5.2). He has been filling up the stat sheet daily of late and is the subject of my best Royals vs. Tigers player prop.

Witt turned in his second straight multi-hit game yesterday to extend his hitting streak to 10 games, and he has now hit safely in 16 of 18 games this month. He is also 6-for-14 with two home runs in his career against Mize.

If Witt doesn’t plate himself with another home run (those best odds are +400 via FanDuel), this remains a confident play with him hitting in front of Vinnie Pasquantino, who was batting .306 with six home runs and 17 RBI over his previous 10 games entering yesterday.

Witt has scored a run in five straight games and eight of the previous nine, so these plus-money odds where one would net profits in the exact amount of their initial winning wager are a steal at DraftKings.

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❓MLB betting FAQs

Who is the favorite to win Royals vs. Tigers?

The Tigers are favored vs. the Royals at -155 odds, giving Detroit an implied 60.78% win probability, according to our odds converter.

How do betting odds work?

Betting odds represent the probability of a specific outcome and determine how much money you can win on a bet. There are three main formats: American odds, Decimal odds, and Fractional odds. In the U.S., American odds are most common.

What is the run line in baseball?

The run line in baseball is a form of point spread betting unique to MLB. It typically sets a standard spread of 1.5 runs, meaning the favored team must win by at least two runs to cover the run line, while the underdog can lose by one run or win outright to cover.

What does moneyline mean in betting?

The moneyline in betting refers to a wager on which team or player will win the game outright, with no point spread involved. It’s the most straightforward type of sports bet - just pick the winner.

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Written by:
Mike Spector

Mike started in the sports writing industry in July 2019, and gained a lot of followers in his first year after finishing with the No. 2 overall record in an annual NFL betting competition, which made picks against the spread, and from an Over/Under and moneyline perspective. Mike is an avid fan of the NFL, MLB, tennis, and all college sports. In his opinion, March Madness is the best sporting event there is, and he's especially euphoric starting with conference tournament time in college basketball. Mike's a big advocate of "fading the public" and making plays that are contrarian, constantly citing that "there are reasons why they have those big shiny buildings in Las Vegas." When making wagers, Mike always scours the best odds at all of the major sports betting sites, where he mostly sifts through DraftKings, FanDuel, BetMGM, and bet365. He's tried several others and is of the firm belief that bettors should not just stick to one sportsbook, as there is always likely better value to be had with the same wager. In addition, while Mike received his undergraduate degree from Villanova University, he has no issue betting against the Wildcats when it comes to college basketball wagering, and suggests other bettors should always put their “head” before their “hearts.”