Red Sox vs. Twins Prediction, Odds & Best Bets: Can Boston Bounce Back After Walk-Off Loss?

Boston was beaten in walk-off fashion in the series opener, but can the Red Sox respond with a strong showing in Minnesota?

Gabe Henderson

Last Updated: July 29, 2025 4:47 PM EDT • 4 minute read

Red Sox vs. Twins Prediction, Odds & Best Bets: Tuesday, July 29 — Pictured: Boston Red Sox starting pitcher Lucas Giolito (54) pitches as we make our Red Sox vs. Twins prediction. Photo by Bob DeChiara via Imagn Images.

Rain delays and late rallies stole the show in the series opener between Boston and Minnesota, and my Red Sox vs. Twins prediction expects more excitement in tonight's matchup.

First pitch is set for 7:40 p.m. ET (NESN, Twins.TV) from Target Field in Minneapolis. The best sports betting sites list Boston as a -118 betting favorite, with Minnesota trading at +105 to win outright.

My Red Sox vs. Twins best bets reluctantly back the visitors behind a strong outing from their starting pitcher, Lucas Giolito.

Red Sox vs. Twins prediction: Red Sox to win (-118 via FanDuel) ⭐⭐
Best Red Sox vs. Twins player props: Lucas Giolito Over 5.5 strikeouts (+105 via BetMGM) ⭐⭐⭐⭐

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✅ Red Sox vs. Twins prediction: Red Sox to win (-118 via FanDuel)

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The Red Sox's wretched road record (23-30) earned another black mark yesterday after Jordan Hicks failed to seal the deal for the visitors in the ninth. However, my Red Sox vs. Twins prediction anticipates a better showing from Boston in this bounce-back spot.

Whereas the pitching plan for the hosts is anybody's guess, Alex Cora turns to old reliable with his team in need of a victory. Giolito has been given the starting nod for the Sox, and he's been a rock in the team's rotation recently.

Boston has won straight up in eight of Giolito's last 10 starts with the pitcher picking up the winning decision on five of those occasions. He's historically dominated Minnesota's lineup, too. The regular starters in the Twins' ranks are hitting a combined .218 versus the former division foe. The pitching matchup is the biggest advantage Boston has in this contest.

My Red Sox vs. Twins best bet backs Boston at two-star confidence, as I'm still not comfortable with the visitors' road resume. The -118 odds at the best sports betting apps imply a 54.13% probability that Giolito gets the Red Sox back on track tonight.

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✅ Best Red Sox vs. Twins player prop: Lucas Giolito Over 5.5 strikeouts (+105 via BetMGM)

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I've already alluded to Giolito's triumphant history against Twins hitters, and my Red Sox vs. Twins player prop takes advantage of those trends. I'm betting on Giolito to clear 5.5 strikeouts once again, which would be the fifth such instance in his last eight starts.

Giolito's held Minnesota batters to a .218 average, but perhaps the most impressive stat is that he's struck them out at a 36.63% clip across 101 at-bats. Byron Buxton (9 Ks) and Carlos Correa (7 Ks) have particularly struggled against the right-hander.

Given Giolito has gone Over this prop in three of his last four, I'll happily take a flier at the plus-money price offered by BetMGM. The other best sportsbooks offer the same play at odds ranging from +100 to -110.

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Written by:
Gabe Henderson

Gabe Henderson is a sports betting writer from Houston, Texas. He graduated from Louisiana State University in 2022 with a bachelor's degree in Mass Communication. Gabe developed an interest in sports betting while in college due to its legalization in Louisiana. He turned his passion into a career shortly after, joining The Advocate/NOLA.com as a Sports Betting Content Coordinator, where he spent two years. Gabe wore many hats before graduating as he led FanSided's coverage of Chelsea FC as a Site Expert with "The Pride of London." He was also the Editor-in-Chief of the LSU Gumbo Yearbook for two years. Gabe became a part of the SportsbookReview.com team in late 2024. He brings with him an extensive knowledge of many sports, including — but not limited to — NFL, NCAA, MLB, NBA, soccer, and UFC.