Red Sox vs. Blue Jays Prediction, Odds & Expert Picks Tonight: MLB Best Bets for Sept. 25
My Red Sox vs. Blue Jays prediction has Boston finishing off a series sweep after dominating the last two games in Toronto.
The Blue Jays are surprisingly a -140 betting favorite tonight ahead of first pitch at 7:07 p.m. ET at Rogers Centre.
My MLB picks target Blue Jays star Vladimir Guerrero Jr. to find his offense again. Our Mike Spector also likes Guerrero to go yard in his best home run predictions today.
⚾ Red Sox vs. Blue Jays prediction
MLB odds subject to change.
- Moneyline pick: Red Sox (+125 via BetMGM) ⭐⭐⭐
- Run line pick: Red Sox +1.5 (-178 via Caesars) ⭐⭐⭐
- Over/Under pick: Over 8 (-105 via DraftKings) ⭐⭐
📝 Red Sox vs. Blue Jays preview & best bet
Track the latest MLB scores for line movement and matchup info.
🧦 Red Sox ML (+125) ⭐⭐⭐
This line doesn’t make much sense to me. The Blue Jays have lost six of seven games overall and are struggling to do much of anything at the plate. They’ve scored just 12 runs over their last six games.
Red Sox righty Brayan Bello has been excellent on the road in 2025, posting a 3.02 ERA and .219 opponents’ batting average across 59 2/3 innings. The Blue Jays, meanwhile, are turning things over to the bullpen after bumping Shane Bieber’s start back to Friday.
A struggling offensive attack and a bullpen day doesn’t feel like a great recipe to help Toronto snap out of its recent funk.
One of the best sports betting sites, BetMGM, offered +125 odds on the Red Sox to win, which nets out a profit of $12.50 on a $10 bet. The +125 odds have an implied probability of 44.44%.
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💰 Best Red Sox vs. Blue Jays player prop bet
Our MLB player prop odds tool shows the best odds for every market across legal sportsbooks in your area.
⬆️ Vladimir Guerrero Jr. Over 1.5 hits, runs, and RBI (-131) ⭐⭐⭐
Vladimir Guerrero Jr. has been scuffling at the plate of late, mustering only four hits over his last 26 at-bats with one run scored and two RBI during that span.
I still like the value here with some sportsbooks offering this as high as -145. Guerrero has seen Bello well in his career, hitting .407 with a 1.206 OPS, two home runs, and 10 RBI in 27 career at-bats against the Red Sox right-hander.
A $10 bet on Guerrero’s Over pays out a profit of $7.63 at DraftKings. The -106 odds have an implied probability of 56.71%.
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📊 Red Sox vs. Blue Jays odds: Sept. 25
MLB odds update live in real time.
📈 Red Sox vs. Blue Jays betting odds analysis
Toronto opened as high as a -150 home favorite despite its recent struggles. Some sportsbooks have offered the Blue Jays as low as -132, but the Red Sox are a fairly sizeable underdog across the board.
🔢 Red Sox vs. Blue Jays stats
Season stats courtesy of baseball-reference.com.
| Red Sox (87-71) | Statistic (per game) | Blue Jays (90-68) |
|---|---|---|
| 4.91 | Runs | 4.87 |
| 8.78 | Hits | 8.99 |
| .255 | AVG | .265 |
| .423 | SLG | .424 |
| .748 | OPS | .757 |
| 3.73 | ERA | 4.24 |
| 8.43 | K/9 | 8.91 |
| 3.28 | BB/9 | 3.22 |
| 1.03 | HR/9 | 1.32 |
🚑 Red Sox vs. Blue Jays injuries
📺 Red Sox vs. Blue Jays game info
- When: Thursday, Sept. 25
- First pitch: 7:07 p.m. ET
- Where: Rogers Centre (Toronto)
- How to watch: Local TV
💡 Expert MLB predictions today
- MLB home run predictions today
- Mets vs. Cubs prediction
- Red Sox vs. Blue Jays prediction
❓ Red Sox vs. Blue Jays FAQs
Who is favored to win Red Sox vs. Blue Jays?
The Blue Jays are the -138 favorite to defeat the Red Sox at home on Thursday.
What is the run line for Red Sox vs. Blue Jays?
Toronto is a -1.5 run line favorite against Boston in Thursday’s matchup.
What is the Over/Under for Red Sox vs. Blue Jays?
The total for Thursday’s game between the Red Sox and Blue Jays is 8.
What are the best bets for Red Sox vs. Blue Jays?
My best bets for Thursday’s Red Sox vs. Blue Jays game are Boston moneyline (+125) and Vladimir Guerrero Jr. Over 1.5 hits, runs, and RBI (-131).
When is the Red Sox vs. Blue Jays game?
First pitch is set for 7:07 p.m. ET on Thursday at Rogers Centre in Toronto.
How do baseball odds work?
When betting on MLB, the run line shows how many runs the favorite needs to win by in order to cash the bet. For example, a favorite of -1.5 must win by two or more runs to cover the run line, while an underdog at +1.5 must win outright or lose by one run to cover the run line.
Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total of runs will be higher or lower than the set number.
You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.
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