Phillies vs. Astros Prediction, Odds & Best Bets: Back Wheeler to Deal in Houston

Zack Wheeler is making noise in the Cy Young race, and we expect that to continue tonight in H-Town.

Last Updated: June 25, 2025 2:30 PM EDT • 3 minute read

Phillies vs. Astros Prediction, Odds & Best Bets: Wednesday, June 25 — Pictured: Philadelphia Phillies starting pitcher Zack Wheeler (45), who is featured in our Phillies vs. Astros prediction, looks on. Photo by Kyle Ross / Imagn Images.

Zack Wheeler takes the mound tonight for the Philadelphia Phillies (47-32) as they visit the Houston Astros (46-33) at Daikin Park, and he's the focal point of our Phillies vs. Astros prediction, odds, and best bets.

We're backing Wheeler to slice through a struggling Astros lineup, with first pitch scheduled for 8:10 p.m. ET. Here are our best picks for tonight:

Phillies vs. Astros prediction: Phillies +1.5 (+110 via Caesars) ⭐⭐⭐
Over/Under prediction: Under 7.5 (-115 via DraftKings) ⭐⭐⭐
Best player prop pick: Zack Wheeler Under 1.5 earned runs allowed (+105 via BetMGM) ⭐⭐⭐⭐⭐

⚾ Phillies vs. Astros predictions & odds

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🧢 Phillies vs. Astros starting pitchers

Phillies: Zack Wheeler (7-2, 2.61 ERA)
Astros: Colton Gordon (2-1, 4.54 ERA)

💰 Phillies vs. Astros prediction & best bet

✅ Best bet: Zack Wheeler Under 1.5 earned runs allowed
📊 Best odds: +105 via BetMGM ($10 to win $10.50)

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We backed Wheeler's strikeout props ahead of his last start against the Mets, when he punched out eight batters through five scoreless innings. That helped him take the MLB lead in strikeout rate (32.9%) while boasting the best xERA (2.36) and second-best SIERA (2.67) among qualified starters.

The Astros rarely strike out and feature MLB's highest zone contact rate (84.8%). But they're tied for 16th in runs per game (4.2) thanks to a lack of power production. That's especially been an issue since Yordan Alvarez suffered a hand injury on May 2. He's still out for this one.

Wheeler has cashed this prop in three straight starts and six of his last seven, which is why it's dealing as short as -110 via bet365. Instead, we can take advantage of these +105 odds via BetMGM, which imply a mere 48.78% chance that he allows fewer than two runs for a fourth consecutive outing.

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Written by:
C Jackson Cowart

C Jackson Cowart is a publishing editor and lead writer for Sportsbook Review. An award-winning writer, reporter, and editor with a decade of sports media experience, "C-Jax" has worked with ESPN, Forbes, theScore, and various daily newspapers before joining the Sportsbook Review team. He's a proud graduate of the University of North Carolina, where he served as a beat writer for the Tar Heels' championship run through the NCAA men's basketball tournament in 2017. Jackson has spent the last five years covering sports betting as a predictive analyst, features writer, and industry reporter. Since joining the team in 2023, he's played a key role in Sportsbook Review's coverage of the Super Bowl, March Madness, and NBA playoffs while serving as the lead writer for the growing WNBA and NASCAR betting scenes. Though he's cashed some big bets over the years -- including Lamar Jackson to win MVP (twice) -- he's still haunted by enough second-place bet slips to wallpaper his home office. While Jackson is a committed "process over results" bettor with a keen eye for advanced stats and subtle bias in futures markets, he also embraces sports betting as a vehicle for entertainment and personal investment. He's written about everything from hot dogs to groundhogs and still hasn't forgiven his "inside source" for a sabotaged bet on the Gatorade color in Super Bowl LV.