Guardians vs. Astros Prediction, Odds & Best Bets: Can Ramirez Push Cleveland to Sweep of Houston?

The Guardians are on the verge of an unlikely sweep of the Astros, and Jose Ramirez can lead the way tonight.

Sean Tomlinson

Last Updated: July 9, 2025 1:49 PM EDT • 5 minute read

Pictured Cleveland Guardians third baseman Jose Ramirez celebrates after scoring on a grand slam, and he'll be key to our Guardians vs. Astros prediction. Photo by Ken Blaze / Imagn.

The Cleveland Guardians are well-positioned for a surprise sweep of the World Series odds-contending Houston Astros as we dive into our Guardians vs. Astros prediction.

The Guardians are just two games removed from snapping a plummet when the team lost 10 straight contests and was starved for offense while being shut out five times during that disastrous stretch. Yet a different team has been showing up for at least two nights in Houston, with the Guardians tallying 17 combined runs while taking consecutive games on the road.

They'll look to snatch all three in Houston as we make our Guardians vs. Astros best bets based on odds from our best MLB betting sites, with the first pitch slated for 8:10 p.m. ET from Daikin Park.

Guardians vs. Astros prediction: Guardians to win (+132 via FanDuel) ⭐⭐⭐⭐
Best Guardians vs. Astros player props: Jose Ramirez Over 1.5 total bases (+100 via BetMGM) ⭐⭐⭐⭐

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✅ Guardians vs. Astros prediction: Guardians to win (+132 via FanDuel)

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The Guardians could promptly turn into a pumpkin again while going back to being the offensively challenged team that averaged an incomprehensible 1.5 runs per outing during that 10-game losing streak.

But that's a tomorrow problem, and tonight it's time to ride the upset odds again. Just make sure you're doing it at FanDuel. You always want the juiciest odds while rolling with the plus-money underdog, and the +132 through FanDuel edges out several of the other best sports betting sites for your Guardians vs. Astros prediction, including Caesars down at +118.

Slade Cecconi will head to the mound tonight for Cleveland. He's susceptible to the long ball at times while posting a 1.7 HR/9. But a quality 3.56 ERA shows an ability to minimize the damage of those dingers while limiting baserunners. He's allowed two or fewer earned runs in five of his last six starts, and his K/9 has increased from 7.5 last season to 8.8 now.

The hurler is a central figure in our Guardians vs. Astros best bet and in another upset bid for Cleveland.

💰 Best Guardians vs. Astros player props

✅ Best Guardians vs. Astros player prop: Jose Ramirez Over 1.5 total bases (+100 via BetMGM)

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There are times when it's best to just follow what looks to be an easy path to your bet cashing. That applies to one of our best Guardians vs. Astros player props, and it's often just the right mantra in general when Jose Ramirez is involved.

The masher who does all he can to almost single-handedly lift up the Guardians' offense has clubbed three home runs over his last five games. He's making consistent contact as always this season while racking up hits, with his .299 average that would be a high since 2017 if the season ended today.

Merely piling up hits is clearly key to any total bases wager, but quality contact is also present from Ramirez with a squared-up rate that sits in the 88th percentile, according to Baseball Savant. He's giving himself a chance to tag one more often, too, with a strikeout rate (11.1) that rests in the bottom 5% leaguewide.

Ramirez brings all that to a matchup against Astros lefty Brandon Walter, who's making only his seventh career start. The third baseman is batting .350 with a .922 OPS this season against lefties this season, far better than his .276 and .843 against righties. Walter has given up five-plus earned runs in two of his last three starts.

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Written by:
Sean Tomlinson

Sean Tomlinson has been in the sports media wilderness since 2009, and he joined Sportsbook Review in 2021. His work has been referenced in The New York Times and Forbes. He's also made appearances on The Fan 590 and TSN 1050. Sean is a regular bettor who places bets daily while using a handful of books. Most frequently, he uses FanDuel and bet365 due to the quality experience on those apps. While he'll often take an analytical approach, Sean enjoys the fun, recreational side of betting too, and embraces alternative markets on events like the Westminster Dog Show or Eurovision, or the many novelty props tied annually to the Super Bowl, for example. Beyond sports, Sean is also interested in the betting markets tied to politics, and especially those connected to American elections. He sees betting as a way to explore and engage in a deeper way, and takes that same view to his work. He plays poker periodically too, and is an avid fantasy sports player. Sean also previously spent time with Bleacher Report and theScore, all after earning his media studies degree from the University of Guelph-Humber.