Giants vs. Padres Prediction, Odds & Best Bets: Value on San Francisco Behind Verlander

Last Updated: August 21, 2025 9:56 AM EDT • 4 minute read X Social Google News Link

The San Francisco Giants and San Diego Padres meet for the final time this season, which should be good news for Giants fans given the Padres’ dominance of this rivalry. But I am backing San Francisco to jump out to an early lead as +136 moneyline underdogs through the first five innings at our top sports betting sites as my Giants vs. Padres prediction.
This series finale begins at 4:10 p.m. ET at Petco Park (Padres Television Network, NBCS BA). Our Giants vs. Padres best bets have faith once again in Justin Verlander to maintain his elite numbers against one of San Diego’s hottest sluggers.
⚾ Giants vs. Padres prediction & odds
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💰 Giants vs. Padres prediction & best bet
✅ Giants vs. Padres prediction: Giants first five innings moneyline (+136 via FanDuel)
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San Diego has owned this head-to-head series, winning nine of the first 12 matchups. But there is value in San Francisco’s first five innings moneyline, which I am backing with my Giants vs. Padres prediction, so as to stay away from San Diego’s dominant bullpen late.
San Diego has only won one non-Nick Pivetta start in its last seven games and used another one of his dominant outings to snap a four-game losing streak on Tuesday. But the Padres had also trailed for 34 consecutive innings entering that game and may get caught looking ahead to their last massive three-game series against the Los Angeles Dodgers starting tomorrow.
San Diego has gotten behind early often, losing the first inning in three of its last five games. While that has some appeal from a YRFI perspective, I am banking on San Francisco to lead after five innings as my Padres vs. Giants best bet behind Justin Verlander, who has allowed one or fewer earned runs in four of his last five starts.
This wager has value since the Padres are 4-5 in Dylan Cease’s last nine starts. And the odds are clearly most desirable at FanDuel among the best sports betting apps, as San Francisco’s first five innings moneyline odds are as low as +118 (carrying a 45.87% implied probability) at the low end of the market.
📊 Live Giants vs. Padres odds: Thursday, 4:10 p.m. ET

💰 Best Giants vs. Padres player prop
✅ Best Giants vs. Padres player prop: Ramon Laureano Under 0.5 hits (+155 via bet365)
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In just 17 games with San Diego entering Wednesday, Laureano was slashing .313/.371/.609 with four home runs and 12 RBIs. He then added two more hits in yesterday’s 8-1 win.
But Verlander has gotten the best of him more often than not in their head-to-head encounters, so there is value on the slugger going hitless as my best Giants vs. Padres player prop.
Laureano is 2-for-13 with one extra-base hit in his career against Verlander, and seven of his 11 outs have been strikeouts.
Verlander has allowed three or fewer hits in three of his previous five starts, two of which have come on the road.
The value on this wager at bet365 is too good to pass up, as Laureano’s odds to go without a hit are as short as +120 elsewhere at the best MLB betting sites. A $10 winning wager at these +155 odds would net $15.50 in profits.
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❓MLB betting FAQs
Who is the favorite to win Giants vs. Padres?
The Padres are favored vs. the Giants at -188 odds, giving San Diego an implied 65.28% win probability, according to our odds converter.
How do betting odds work?
Betting odds represent the probability of a specific outcome and determine how much money you can win on a bet. There are three main formats: American odds, Decimal odds, and Fractional odds. In the U.S., American odds are most common.
What is the run line in baseball?
The run line in baseball is a form of point spread betting unique to MLB. It typically sets a standard spread of 1.5 runs, meaning the favored team must win by at least two runs to cover the run line, while the underdog can lose by one run or win outright to cover.
What does moneyline mean in betting?
The moneyline in betting refers to a wager on which team or player will win the game outright, with no point spread involved. It’s the most straightforward type of sports bet - just pick the winner.
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Mike Spector X social