Dodgers vs. Giants Prediction, Odds & Expert Picks: MLB Best Bets for Sept. 12
Both Los Angeles and San Francisco have been swinging hot bats as of late, and I think there’s a decent chance for that trend to continue as I make my Dodgers vs. Giants prediction. First pitch for the series opener is set for 10:15 p.m. ET on Friday from Oracle Park in San Francisco.
My MLB picks like the value on Dodgers veteran hitter Max Muncy to put together a productive night at the plate at a stadium he’s enjoyed hitting at throughout his career, and I’m riding with the Over on one of his player props.
⚾ Dodgers vs. Giants expert picks & predictions
MLB odds subject to change.
- Moneyline pick: Dodgers (-154 via FanDuel) ⭐⭐
- Run line pick: Dodgers -1.5 (+116 via FanDuel) ⭐⭐⭐
- Over/Under pick: Over 7.5 (-114 via FanDuel) ⭐⭐⭐
📝 Dodgers vs. Giants preview & best bet
Track the latest MLB scores for line movement and matchup info.
⬆️ Over 7.5 runs (-114) ⭐⭐⭐
The Dodgers and Giants have played some surprisingly high-scoring games in 2025, going Over the total in three of their five head-to-head meetings.
Both teams are coming into the series in good form at the plate, averaging 6.3 runs per game over their past three contests. Even with Yoshinobu Yamamoto and Justin Verlander forming an imposing pitching matchup, I think the two lineups are more than capable of having success. Yamamoto has been inconsistent in three career starts against the Giants, posting a 4.67 ERA with nine walks and three home runs across 17 1/3 innings.
The Giants, in particular, have been raking in September, ranking first in home runs (19), second in wRC+ (141), second in batting average (.288), and second in OPS (.868).
FanDuel, one of the best sports betting sites, offers -114 odds on the Over, which nets out a profit of $8.77 on a $10 bet. The -114 odds have an implied probability of 53.27%.
💰 Best Dodgers vs. Giants player prop bet
Our MLB player prop odds tool shows the best odds for every market across legal sportsbooks in your area.
🔥 Max Muncy Over 1.5 hits, runs, and RBI (+105) ⭐⭐⭐
Max Muncy has had a long and successful career that has been defined by his ability to do damage against right-handed pitching. It’s been more of the same in 2025, as Muncy is slashing .279/.420/.536 with 15 home runs and 55 RBI against righties.
The veteran has also enjoyed his time at Oracle Park with 11 homers and a .958 OPS in 43 games in San Francisco. Muncy has punished fastballs in 2025, hitting .281 with 11 home runs and a .593 slugging percentage. That could be a recipe for success against Verlander’s fastball, which has permitted a .281 average, nine home runs, and a .533 expected slugging percentage this season.
A $10 wager on Muncy’s Over pays out a profit of $10.50 at BetMGM. The +105 odds have an implied probability of 48.78%.
📊 Dodgers vs. Giants odds: Sept. 12
MLB odds update live in real time.
📈 Dodgers vs. Giants betting odds analysis
Los Angeles opened as high as a -163 favorite, with some of the best sports betting apps offering them as low as -154 as of Friday morning.
🔢 Dodgers vs. Giants stats
Season stats courtesy of baseball-reference.com.
| Dodgers (82-64) | Statistic (per game) | Giants (74-72) |
|---|---|---|
| 5.05 | Runs | 4.36 |
| 8.52 | Hits | 7.95 |
| .252 | AVG | .239 |
| .437 | SLG | .392 |
| .765 | OPS | .706 |
| 4.03 | ERA | 3.76 |
| 9.21 | K/9 | 8.61 |
| 3.44 | BB/9 | 3.16 |
| 1.14 | HR/9 | 0.87 |
🚑 Dodgers vs. Giants injuries
📺 Dodgers vs. Giants game info
- When: Friday, Sept. 12
- First pitch: 10:15 p.m. ET
- Where: Oracle Park, San Francisco
- How to watch: Local TV
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❓ Dodgers vs. Giants FAQs
Who is favored to win Dodgers vs. Giants?
The Dodgers are a -154 favorite to defeat the Giants on the road on Friday.
What is the run line for Dodgers vs. Giants?
Los Angeles is a -1.5 run line favorite against San Francisco in Friday’s matchup.
What is the Over/Under for Dodgers vs. Giants?
The total for Friday’s game between the Dodgers and Giants is 7.5.
What are the best bets for Dodgers vs. Giants?
My best bets for Friday’s Dodgers vs. Giants game are Over 7.5 runs (-114) and Max Muncy Over 1.5 hits, runs, and RBI (+105).
When is the Dodgers vs. Giants game?
First pitch is set for 10:15 p.m. ET on Friday.
How do baseball odds work?
When betting on MLB, the run line shows how many runs the favorite needs to win by in order to cash the bet. For example, a favorite of -1.5 must win by two or more runs to cover the run line, while an underdog at +1.5 must win outright or lose by one run to cover the run line.
Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total of runs will be higher or lower than the set number.
You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.
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