Cubs vs. Brewers Prediction, Odds & Best Bets: Milwaukee Doubles Divisional Advantage

The Brewers gained a leg-up on the Cubs in the NL Central with their win in the series opener. Can Milwaukee double its lead tonight?

Gabe Henderson

Last Updated: July 29, 2025 4:47 PM EDT • 4 minute read

Cubs vs. Brewers Prediction, Odds & Best Bets: Tuesday, July 29 — Pictured: Milwaukee Brewers designated hitter Christian Yelich (22) hits a double as we make our Cubs vs. Brewers prediction. Photo by Benny Sieu via Imagn Images.

Milwaukee took the NL Central lead back with a win over Chicago in the series opener, and my Cubs vs. Brewers prediction expects the hosts' advantage to double tonight.

The best sports betting sites list the Brewers as -125 betting favorites, with a game total set at O/U 8.5 runs. First pitch is set for 7:40 p.m. ET (MSN, FDSN Wisconsin) from American Family Field in Milwaukee.

My Cubs vs. Brewers best bets look for the Brew Crew to stay hot behind Christian Yelich's bat.

Cubs vs. Brewers prediction: Brewers to win (-125 via BetMGM) ⭐⭐⭐
Best Cubs vs. Brewers player props: Christian Yelich Over 1.5 bases (+125 via Caesars) ⭐⭐⭐

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✅ Cubs vs. Brewers prediction: Brewers to win (-125 via BetMGM)

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My fatal flaw when betting on baseball is often my overreliance on the importance of solid starting pitching. It proved to be my downfall in Monday's series opener, when Matthew Boyd's fine form clouded my judgment. I come into today's Cubs vs. Brewers prediction with a clear conscience, though, and I'm backing the Brew Crew.

Milwaukee is the hottest team in baseball at the moment, boasting the best record in the majors thus far. The Brewers are 20 games above .500 thanks to their success at home. Only the Blue Jays and Mets have better records than Milwaukee (35-19) in similar games.

The hosts' starter tonight, Quinn Priester, has been particularly impactful at home. He's racked up a 5-1 record across eight starts with a 3.02 ERA at American Family Field. The best sports betting apps are banking on another big performance from Priester - and after Monday's misguided pick, so am I.

The Brewers are -125 moneyline favorites to increase their lead in the National League Central to two games tonight, which would turn a winning $10 bet into an $8 profit.

💰 Best Cubs vs. Brewers player props

✅ Best Cubs vs. Brewers player prop: Christian Yelich Over 1.5 bases (+125 via Caesars)

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Opposing the Brew Crew tonight will be a familiar face, Colin Rea, who played in 59 games with Milwaukee from 2021 to 2024. Rea's career path means many of the Brewers' batters haven't faced him in live game situations, so we have limited sample sizes to base our best Cubs vs. Brewers player prop on.

While Yelich only has two games with 2-plus bases since returning from the All-Star break, I'm taking a flier on him to achieve this feat in back-to-back nights. The 33-year-old terrorized Chicago with six total bases in the series opener, and his success against Rea makes me believe he can do it again.

Yelich has faced his former teammate four times in his career: he's hitting .500 across those at-bats with a pair of singles. A $10 winning wager on Yelich Over 1.5 bases returns $12.50 at the best sportsbooks. I like the versatility on this bet - as opposed to Over 1.5 hits - with multiple ways to cash the ticket.

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How do betting odds work?

Betting odds represent the probability of a specific outcome and determine how much money you can win on a bet. There are three main formats: American odds, Decimal odds, and Fractional odds. In the U.S., American odds are most common.

What is the run line in baseball?

The run line in baseball is a form of point spread betting unique to MLB. It typically sets a standard spread of 1.5 runs, meaning the favored team must win by at least two runs to cover the run line, while the underdog can lose by one run or win outright to cover.

What does moneyline mean in betting?

The moneyline in betting refers to a wager on which team or player will win the game outright, with no point spread involved. It’s the most straightforward type of sports bet - just pick the winner.

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Written by:
Gabe Henderson

Gabe Henderson is a sports betting writer from Houston, Texas. He graduated from Louisiana State University in 2022 with a bachelor's degree in Mass Communication. Gabe developed an interest in sports betting while in college due to its legalization in Louisiana. He turned his passion into a career shortly after, joining The Advocate/NOLA.com as a Sports Betting Content Coordinator, where he spent two years. Gabe wore many hats before graduating as he led FanSided's coverage of Chelsea FC as a Site Expert with "The Pride of London." He was also the Editor-in-Chief of the LSU Gumbo Yearbook for two years. Gabe became a part of the SportsbookReview.com team in late 2024. He brings with him an extensive knowledge of many sports, including — but not limited to — NFL, NCAA, MLB, NBA, soccer, and UFC.