Braves vs. Guardians Predictions, Odds & Best Bets: Can Harris Continue Run-Scoring Spree?

Last Updated: August 15, 2025 8:43 AM EDT • 3 minute read X Social Google News Link

The Cleveland Guardians look to continue closing in on an American League playoff spot when they host the Atlanta Braves in an interleague series opener at Progressive Field at 7:10 p.m. ET (MLBN, FDSN, Guardians TV). Our Braves vs. Guardians prediction backs an Atlanta victory as +106 moneyline underdogs at our top sports betting sites because of Cleveland’s poor interleague record.
Our Braves vs. Guardians best bets are also backing one of Atlanta’s hottest sluggers who has been on a run-scoring tear for much of this week.
⚾ Braves vs. Guardians prediction & odds
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📊 Live Braves vs. Guardians odds: Friday, 7:10 p.m. ET
💰 Braves vs. Guardians prediction & best bet
✅ Braves vs. Guardians prediction: Braves to win (+106 via FanDuel)
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When these odds first came out, Atlanta was supposed to trot out newly acquired starting pitcher Erick Fedde (and his poor ERA north of six while with the Braves). But now that the team has pivoted to rookie Hurston Waldrep as its starting pitcher, I am changing my moneyline pick to Atlanta as my Braves vs. Guardians prediction.
Waldrep has allowed two earned runs in 11 2/3 innings this season. He has good strikeout potential with 10 Ks in that span, which is important against a Guardians lineup that still ranks dead last in the majors in BABIP.
While Cleveland is 7-1 in its eight series in the second half, I have confidence in Waldrep in his first road start as my Braves vs. Guardians best bet. After all, the Guardians are just 4-3 in Joey Cantillo’s seven outings since the start of July, with three of those wins coming against last-place American League teams. Cleveland is also just 19-23 in interleague games.
The +106 odds at FanDuel represent great value for Atlanta to take this series opener, compared to the +105 or lower at our other best MLB betting sites.

💰 Best Braves vs. Guardians player prop
✅ Best Braves vs. Guardians player prop: Michael Harris II Over 0.5 runs (+155 via bet365)
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There are few batters hotter at the plate than Atlanta center fielder Michael Harris II at the moment, and he is the focal point of our Braves vs. Guardians player prop.
Harris now has six consecutive multi-hit games and has hit safely in seven straight overall. In that span, he has raised his batting average 16 points and scored seven total runs.
Harris has a great chance of scoring a run today with Atlanta’s team total O/U set at 4.5 and juiced as high as -120 at some of our best sports betting apps. He has crossed the plate in four consecutive games, and bet365 has the best odds for him to do so for a fifth straight time, trumping the next best offer of +140 at DraftKings.
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Mike Spector X social