Best Home Run Predictions Today: MLB Odds, Picks & Prop Bets for Tonight Sept. 19

Our best home predictions for today have a four-pack of players we think will hit a long bomb, focusing on Pete Alonso.

Mike Spector

Last Updated: September 19, 2025 1:53 PM EDT • 4 minute read

Home Run Predictions Today: Best MLB Odds, Picks & Prop Bets for Tonight Sept. 19 — Pictured: Los Angeles Angels left fielder Taylor Ward (3) reacts after hitting a solo home run. Photo by Benny Sieu-Imagn Images

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New York Mets right handed slugger Pete Alonso has caught fire, homering in four consecutive games, and I am making his pursuit of a career-best fifth straight game with a home run the centerpiece of my best home run predictions today.

Joining Alonso in my four-pack of home run picks are Trent Grisham, Ian Happ, and a red-hot batter in Taylor Ward playing a series opener at hitter-friendly Coors Field.

A $10 parlay on all four sluggers going yard would pay out over $4,400 in profits if they all hit a four-bagger.

💰 MLB best home run predictions & odds today: Sept. 19

Best home run predictions today based on the latest MLB odds.

Ian Happ to hit a home run (+370 via FanDuel) ⭐⭐
Trent Grisham to hit a home run (+525 via DraftKings) ⭐⭐⭐
Pete Alonso to hit a home run (+286 via DraftKings) ⭐⭐⭐
Taylor Ward to hit a home run (+330 via FanDuel) ⭐⭐

💣 Best home run prediction today: MLB expert picks & prop bets

Here is my favorite MLB home run bet today and analysis of why it leads my MLB home run predictions.

⚾ Pete Alonso (Mets) to hit a home run (+286) ⭐⭐⭐

Home Run Predictions Today: Best MLB Odds, Picks & Prop Bets for Sept. 19 — Pictured: New York Mets first baseman Pete Alonso (20) runs the bases after hitting a solo home run. Photo by Vincent Carchietta-Imagn Images

With Alonso’s first-inning solo home run yesterday, he is three shy of joining Aaron Judge and Shohei Ohtani as the only active players with at least four seasons of 40-plus home runs.

Alonso has now homered in four straight games for the third time in his career (2019, 2023). In the other two instances where he was going for a fifth straight, he went a combined 1-for-7, including an 0-for-3 performance against today’s opponent, the Washington Nationals.

Alonso and Juan Soto are the second teammates in Mets history to each have a season of 35 home runs and 100 RBIs. The “Polar Bear” is also one of only two players with five straight seasons of 20 doubles and 30 home runs (Ohtani).

These are great odds in an eerily similar spot against the Nationals to make history, even if Nationals southpaw Andrew Alvarez has allowed just one home run in 15 2/3 innings to start his MLB career. DraftKings provides the best payout, and a $10 winning wager at its +286 price with 25.91% implied odds would net $28.60 in profits.

📊 Nationals vs. Mets odds

🚀 Best home run parlay picks

Use our parlay calculator to get the best odds for any parlay.

Ian Happ to hit a home run (+370 via FanDuel)
Trent Grisham to hit a home run (+470 via FanDuel)
Pete Alonso to hit a home run (+285 via FanDuel)
Taylor Ward to hit a home run (+330 via FanDuel)

Parlay odds: +44251 via FanDuel ($10 to win $4,425.11)

💡 Expert MLB predictions today

❓ Best home run predictions FAQs

What are the best home run props for tonight?

My best home run predictions today feature Pete Alonso, Trent Grisham, Ian Happ, and Taylor Ward.

What is a home run bet?

A home run bet is a wager on a hitter to hit a HR at any point during a game. Some sportsbooks allow you to bet on a hitter to not hit a home run, but the most common bet is on them to do so.

Can you parlay home run bets?

Yes, you can parlay home run bets. We've provided our best home run parlay today.

How do I place a home run bet?

To place a home run bet, simply go to your favorite sportsbook and go to the game featuring the player of your choice. Then click on batter props and you should see an option to bet a player to hit a home run.

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Written by:
Mike Spector

Mike started in the sports writing industry in July 2019, and gained a lot of followers in his first year after finishing with the No. 2 overall record in an annual NFL betting competition, which made picks against the spread, and from an Over/Under and moneyline perspective. Mike is an avid fan of the NFL, MLB, tennis, and all college sports. In his opinion, March Madness is the best sporting event there is, and he's especially euphoric starting with conference tournament time in college basketball. Mike's a big advocate of "fading the public" and making plays that are contrarian, constantly citing that "there are reasons why they have those big shiny buildings in Las Vegas." When making wagers, Mike leans on his NFL experience and always scours the best odds at all of the major sports betting sites, where he mostly sifts through DraftKings, FanDuel, BetMGM, and bet365. He's tried several others and is of the firm belief that bettors should not just stick to one sportsbook, as there is always likely better value to be had with the same wager. In addition, while Mike received his undergraduate degree from Villanova University, he has no issue betting against the Wildcats when it comes to college basketball wagering, and suggests other bettors should always put their “head” before their “hearts.”