Best Home Run Predictions Today: MLB Odds, Picks & Prop Bets for Aug. 21

We're getting appealing betting odds for Jose Altuve to go deep as part of our best home run predictions today.

Sean Tomlinson

Last Updated: August 21, 2025 11:24 AM EDT • 4 minute read

We're getting a wildly appealing price for Jose Altuve as part of our best home run predictions today and home run bets today, and our list of four sluggers also includes Freddie Freeman at the Coors Field launchpad.

They're part of a four-legged parlay that will pay out a mammoth nearly $11,500 if it hits.

💰 MLB best home run predictions & odds today: Aug. 21

Here are my best MLB home run predictions and odds today, with my pick confidence based on a 1-to-5-star scale. You can also check out our MLB player prop odds tool for the latest MLB odds at the best legal sportsbooks in your region.

🧨 Jose Altuve to hit a home run (+950 via bet365) ⭐⭐⭐⭐⭐
🧨 Cody Bellinger to hit a home run (+560 via FanDuel) ⭐⭐⭐⭐
🧨 Junior Caminero to hit a home run (+330 via FanDuel) ⭐⭐⭐
🧨 Freddie Freeman to hit a home run (+330 via FanDuel) ⭐⭐⭐⭐

🚀 Best home run parlay picks

Here is our best MLB home run parlay for Thursday's baseball action; use our parlay calculator to get the best odds for any parlay.

💣 Jose Altuve to hit a home run (+870 via FanDuel)
💣 Cody Bellinger to hit a home run (+540 via FanDuel)
💣 Junior Caminero to hit a home run (+330 via FanDuel)
💣 Freddie Freeman to hit a home run (+330 via FanDuel)

Parlay odds: +114685 via FanDuel ($10 to win $11,468.59)

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💣 Best home run prediction today: MLB expert picks & prop bets

Here are my best home run bets today. Check out the rest of our MLB picks along with our guide on how to bet on MLB.

⚾ Jose Altuve (Astros) to hit a home run ⭐⭐⭐⭐

Best odds: +950 via bet365 (bet $10 to win $95)

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We're getting an eye-popping price for Altuve to launch one from our best MLB betting sites today, though there's still a chasm between the top and bottom of the market.

That's why you need to be sure to roll with bet365, which is offering +950. Several of our other best sports betting sites are down around +850 before a significant drop off to DraftKings at +700 and FanDuel at +600.

To varying degrees with the books all over the map, those prices make the pint-sized slugger a long shot to go yard tonight. That's happening perhaps in part because Altuve's Astros are beginning a four-game series in Oriole Park at Camden Yards, which suppresses home runs to righties due to its generous dimensions in left field. It ranks 22nd in dingers allowed to righties this season, according to the park factors at Baseball Savant.

However, the thing about Oriole Park at Camden Yards is that the Orioles play there, and their constantly imploding pitching staff can make any ballpark look small on a given night, especially when Altuve is involved. He's posted a .985 OPS over his last two weeks (12 games) with a .295 batting average and four home runs.

And he'll get to tee off on a team that's allowed the sixth-most home runs leaguewide and enters tonight with MLB's fifth-worst ERA (4.65). It's an evening that will start with Brandon Young on the mound for Baltimore. He was impressive against these same Astros last time out, but Young gave up six earned runs to the Athletics the start prior, and his ERA sits at 5.68.

📊 Astros vs. Orioles odds

💡 Expert MLB predictions today

❓Best home run predictions FAQs

What is a home run bet?

A home run bet is a wager on a hitter to hit a HR at any point during a game. Some sportsbooks allow you to bet on a hitter to not hit a home run, but the most common bet is on them to do so.

Can you parlay home run bets?

Yes, you can parlay home run bets. We've provided our best home run parlay today.

How do I place a home run bet?

To place a home run bet, simply go to your favorite sportsbook and go to the game featuring the player of your choice. Then click on batter props and you should see an option to bet a player to hit a home run.

What are the best home run props for tonight?

Our best home run predictions today feature Jose Altuve, Cody Bellinger, Junior Caminero, and Freddie Freeman.

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Written by:
Sean Tomlinson

Sean Tomlinson has been in the sports media wilderness since 2009, and he joined Sportsbook Review in 2021. His work has been referenced in The New York Times and Forbes. He's also made appearances on The Fan 590 and TSN 1050. Sean is a regular bettor who places bets daily while using a handful of books. Most frequently, he uses FanDuel and bet365 due to the quality experience on those apps. While he'll often take an analytical approach, Sean enjoys the fun, recreational side of betting too, and embraces alternative markets on events like the Westminster Dog Show or Eurovision, or the many novelty props tied annually to the Super Bowl, for example. Beyond sports, Sean is also interested in the betting markets tied to politics, and especially those connected to American elections. He sees betting as a way to explore and engage in a deeper way, and takes that same view to his work. He plays poker periodically too, and is an avid fantasy sports player. Sean also previously spent time with Bleacher Report and theScore, all after earning his media studies degree from the University of Guelph-Humber.