Best Home Run Predictions Today: MLB Odds, Picks & Prop Bets for Aug. 16

Last Updated: August 16, 2025 9:24 AM EDT • 3 minute read X Social Google News Link

After falling short the last few days with my dinger picks, it's time to call in the big guns - such as Brent Rooker - with my best home run predictions today.
Rooker's power is leaving a lot to be desired lately, but the Athletics' Home Run Derby representative has fantastic numbers against tonight's starter for the Angels. My home run bets today are also relying on Byron Buxton, Shohei Ohtani, and Jose Ramirez to get us back on track.
If all four sluggers manage to leave the ballpark, a $10 parlay pays out nearly $2,000!
💰 MLB best home run predictions & odds today: Aug. 16
Here are my best MLB home run predictions and odds today with my pick confidence based on a 1-to-5-star scale. You can also check out our MLB player prop odds tool for the latest MLB odds at the best legal sportsbooks in your region.
🧨 Jose Ramirez to hit a home run (+390 via FanDuel) ⭐⭐⭐
🧨 Byron Buxton to hit a home run (+375 via bet365) ⭐⭐⭐
🧨 Shohei Ohtani to hit a home run (+200 via FanDuel) ⭐⭐⭐⭐
🧨 Brent Rooker to hit a home run (+265 via bet365) ⭐⭐⭐⭐
🚀 Best home run parlay picks
Here is our best MLB home run parlay for Saturday's baseball action; use our parlay calculator to get the best odds for any parlay.
💣 Jose Ramirez to hit a home run (+390 via FanDuel)
💣 Byron Buxton to hit a home run (+290 via FanDuel)
💣 Shohei Ohtani to hit a home run (+200 via FanDuel)
💣 Brent Rooker to hit a home run (+250 via FanDuel)
Parlay odds: +19965 via FanDuel ($10 to win $1,996.55)
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💣 Best home run prediction today: MLB expert picks & prop bets
Here are my best home run bets today. Check out the rest of our MLB picks along with our guide on how to bet on MLB.
⚾ Brent Rooker (Athletics) to hit a home run ⭐⭐⭐⭐
Best odds: +265 via bet365 (bet $10 to win $26.50)
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While Wikipedia claims Arte Moreno is the principal owner of the Los Angeles Angels, we know it's really Brent Rooker. The Athletics' star is hitting .328 with 43 hits - 15 of which are home runs - in 36 career games against the Halos. Three of his 24 home runs this season came against the Angels, as well.
Even though Rooker isn't lighting it up right now, going yard at just a 10% clip over his last 10 outings, I have confidence he can find his power stroke tonight. He's clubbed a pair of dingers to raise his career average to .357 against Los Angeles' starter tonight, Tyler Anderson. The latter has also allowed opponents to take him deep in his last six starts, surrendering 11 moon shots over that span.
Despite his recent struggles in the power department, the best sports betting sites still list Rooker at +265 to hit a home run tonight due to the dominance he's displayed against Anderson historically. Play this at bet365, which offers slightly better odds than competitors, like DraftKings (+225).

📊 Angels vs. Athletics odds
💡 Expert MLB predictions today
- Best home run predictions today
- Pirates vs. Cubs predictions
- Tigers vs. Twins predictions
- Yankees vs. Cardinals predictions
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