Wisconsin vs. Michigan Prediction: Opening Odds & Early Picks for College Football Week 6

Our Wisconsin vs. Michigan prediction breaks down the opening odds and early picks for Week 6, focusing on the Wolverines as a 16.5-point favorite.
Wisconsin vs. Michigan Prediction
Pictured: Michigan quarterback Bryce Underwood runs against Nebraska. Photo by Dylan Widger via Imagn Images.

This Saturday's Big Noon Kickoff game on FOX will be in the Big House at Michigan Stadium in Ann Arbor, Mich., and my Wisconsin vs. Michigan prediction and early picks are backing the home team as a 16.5-point betting favorite as part of our college football predictions for Week 6.

While the opening odds have the Badgers as more than a two-touchdown underdog, my college football picks this week don't expect Luke Fickell to turn things around at Wisconsin any time soon.


🏈 Early Wisconsin vs. Michigan prediction & best bet

Stay ahead with the rest of our early college football predictions for Week 6.

 〽️ Michigan -16.5 (-110) ⭐⭐⭐⭐

The Fickell era in Madison has gone worse than anybody could have expected, with the Badgers sitting at 2-2 and coming off a 17-point loss at home to a Maryland team that was a 10-point underdog. This comes a year after the Badgers finished with a losing record for the first time since 2001. Fickell's seat is getting hotter, and his team is 10-17-2 ATS since the beginning of 2023.

So while winning by 17-plus points is a big ask for Michigan, the Wolverines are equipped to devour their fellow member of the Mustelidae family. With head coach Sherrone Moore back from his suspension and freshman five-star QB Bryce Underwood playing better and better each week, Michigan is poised to cover for the third straight game as a favorite.

The Wolverines are loaded in their front seven and bring a defense that ranks No. 17 in EPA per rush and No. 11 in early downs EPA per play - perfect for stopping Wisconsin offensive coordinator Jeff Grimes' run-first attack. If Underwood and Justice Haynes do their part on offense, Michigan should cover this spread and turn a $10 bet into a $9.09 profit.

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📺️ How to watch Wisconsin vs. Michigan

When: Saturday, Oct. 4 @ noon ET

Where: Michigan Stadium (Ann Arbor, Mich.)

TV: FOX


📊 Wisconsin vs. Michigan odds: Week 6

Latest college football odds updated live in real time.

📈 Wisconsin vs. Michigan opening odds

  • Moneyline: Wisconsin +550 | Michigan -800
  • Spread: Wisconsin +16.5 (-110) | Michigan -16.5 (-110)
  • Over/Under: Over 41.5 (-110) | Under 41.5 (-110)

💡 Wisconsin vs. Michigan odds analysis

Michigan opened as a 15.5 to 16.5-point favorite, with the line seeing minimal movement and most of our best college football betting sites offering the Wolverines between -16.5 and -17.5. With how large a spread that is, I don't expect it to move much more, but I could see it closing with Michigan favored by as many as 18.5 points by kickoff on Saturday. With the spread more likely to move toward the Wolverines, I'd bet Michigan now at -16.5, before the line surpasses the key number of 17.


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