USC vs. Oregon Best Bets: Our Staff Expert Picks for Week 13 College GameDay Matchup

Two former Pac-12 rivals duke it out today at 3:30 p.m. ET (CBS) with College GameDay at Autzen Station in Eugene, Ore., for this de facto College Football Playoff play-in game. We're breaking it down from every angle with our USC vs. Oregon best bets and expert picks for this Big Ten battle as part of our college football Week 13 predictions.

🏈 USC vs. Oregon best bets & expert picks: Week 13

See all of our experts' college football picks for Week 13 based on the latest college football odds.

🔮 USC vs. Oregon prediction

Neither of these teams have a realistic shot at winning the Big Ten, but the winner of this one can essentially punch their ticket to the College Football Playoff by winning today and holding off their rival next week in the season finale.

Our college football expert Rob Paul fully expects that to be Oregon, which features an unstoppable run game and a potential top-10 pick at quarterback. That's why he's backing the Ducks as big home favorites while betting on their defense to hold the Trojans' explosive offense in check, which he breaks down in his full top-25 predictions for every ranked matchup this week.

🔥 USC vs. Oregon player props

While all of the attention for this matchup is focused on the Ducks' run game, the Trojans have found success on the ground as of late behind walk-on redshirt freshman King Miller, who has combined for 567 yards over his last five games.

Our college football expert Matt Jacob is backing the first-year phenom to stay hot today as his best player prop bet for this game, but he's also fading star USC passer Jayden Maiava and targeting Oregon's best red-zone threat in Kenyon Sadiq with his best USC vs. Oregon player props for this critical showdown in Eugene.

💪 USC vs. Oregon anytime touchdown scorer predictions

With an Over/Under game total sitting just shy of 60 points, we could be in store for a fireworks show today at Autzen Stadium. And our college football expert Brenden Schaeffer is targeting two of the best end-zone merchants in the sport while taking a shot on an overlooked tight end for the visitors.

Schaeffer is all over Oregon rusher Jordon Davison to find pay dirt for the 13th time this season as his lone five-star anytime TD bet while buying the plus-money value on USC pass-catchers Makai Lemon and Lake McRee with his best USC vs. Oregon anytime touchdown scorer predictions ahead of this Big Ten clash.

🚀 USC vs. Oregon same-game parlay

Our college football expert Isaiah Sirois has cooked up a three-leg same-game parlay for this high-profile clash today, combining a contrarian play on an alt-spread with the full-game Under and another alt-total for one of the Ducks' secondary stars with his USC vs. Oregon same-game parlay for this Week 13 showdown.

📺 How to watch USC vs. Oregon

• Date: Saturday, Nov. 22
• Kickoff: 3:30 p.m. ET
• Location: Autzen Stadium (Eugene, Ore.)
• TV: CBS