Tulane vs. Ole Miss Predictions: 2025 College Football Playoff Odds, Picks & Best Bet
A lot has changed since the last time these two programs played in September, and as a result, my Tulane vs. Ole Miss predictions are backing the Green Wave to put up a better fight in the College Football Playoff.
Ole Miss is a 17.5-point betting favorite for today's 3:30 p.m. ET (TNT/HBO Max/truTV) matchup from Vaught-Hemingway Stadium in Oxford, Miss., in the third CFP game among the college football bowl games this week.
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🏈 Tulane vs. Ole Miss prediction: 2025 College Football first round
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| Best bets | Odds | Confidence |
|---|---|---|
| Tulane +17.5 | -110 via bet365 | ⭐⭐⭐⭐ |
| Dae'Quan Wright anytime TD | +184 via Caesars | ⭐⭐⭐ |
Tulane +17.5 (-110) ⭐⭐⭐⭐
Tulane is a different team than the one that lost to Ole Miss in September. Since then, the Green Wave's defense has gotten itself together, allowing 24 points or fewer in seven of its last nine games.
All Tulane needs to do is not get blown out, and with Jake Retzlaff's mobility as an X-factor, the Green Wave are No. 28 in offensive SP+. Meanwhile, this is Ole Miss's first game since Lane Kiffin left for LSU.
It's hard to imagine the Rebels won't deal with a few hiccups without Kiffin, especially when it comes to the offense.
Score prediction: Ole Miss 34, Tulane 20
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🙌 Best Tulane vs. Ole Miss TD pick: College Football Playoff first round
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Dae'Quan Wright, TE, Ole Miss: Anytime TD (+184) ⭐⭐⭐
With Kiffin gone, I really don't love the prices available at our best college football betting sites for Ole Miss's top scorers to find the end zone. QB Trinidad Chambliss is between -115 and -138, while Kewan Lacy is -480 to -600, and still between -110 to -130 to score twice.
Meanwhile, Tulane doesn't have a go-to player to bet on to score, outside of Retzlaff, but even he's just even money. Instead, my favorite TD play is backing Rebels tight end Dae'Quan Wright. He's among Ole Miss's most underrated players and will be a challenging cover for a Group of Six defense. Also, our Tulane vs. Ole Miss player props have his quarterback throwing plenty.
Wright is one of the best tight ends in the country after the catch, ranking No. 3 in YAC at his position (331), and his athleticism makes him a mismatch down the seam against a team that doesn't have a linebacker who can run with him.
While Wright has scored just four times this year, one of his most productive games came against Tulane. He finished with 71 yards and a TD the last time the Rebs played the Green Wave.
📝 Top NFL draft prospects for Tulane vs. Ole Miss
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| Player | Position | Key stats | NFL draft grade |
|---|---|---|---|
| Zxavian Harris, Ole Miss | IDL | 7.5 TFLs, 3 sacks | Round 3-5 |
| Dae'Quan Wright, Ole Miss | TE | 489 receiving yards, 4 TDs | Round 3-5 |
| Suntarine Perkins, Ole Miss | LB | 64 tackles, 6.5 TFLs | Round 4-6 |
| Harrison Wallace III, Ole Miss | WR | 719 receiving yards, 3 TDs | Round 4-6 |
| Trinidad Chambliss, Ole Miss | QB | 5th-highest QBR in the country (86.0) | Round 4-6 |
| Princewill Umanmielen, Ole Miss | EDGE | 10 TFLs, 6.5 sacks | Round 4-6 |
| Santana Hooper, Tulane | DL | 9.5 TFLs, 4.5 sacks | Round 5-7 |
| Shadre Hurts, Tulane | OG | 0 sacks, 6 pressures allowed | Round 5-7 |
| Diego Pounds, Ole Miss | OT | 0 sacks, 12 pressures allowed | Round 6-UDFA |
| De'Zhaun Stribling, Ole Miss | WR | 533 receiving yards, 5 TDs | Round 6-UDFA |
📊 Live Tulane vs. Ole Miss odds: College Football Playoff first round
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Tulane vs. Ole Miss opening odds
- Moneyline: Tulane +550 | Ole Miss -800
- Spread: Tulane +16.5 (-110) | Ole Miss -16.5 (-110)
- Over/Under: Over 57 (-110) | Under 57 (-110)
📈 Tulane vs. Ole Miss betting trends
| Tulane | Statistic | Ole Miss |
|---|---|---|
| 11-2 | W-L record | 11-1 |
| 7-6 | ATS record | 7-4-1 |
| 4-9 | O/U record | 6-6 |
| 6.1 | Yards per play | 6.7 |
| 5.5 | Yards allowed per play | 5.2 |
| +0.7 | Turnover margin | -0.2 |
| 5-0 | Last 5 games | 5-0 |
| W, 34-21 vs. North Texas | Previous result | W, 38-19 vs. Mississippi State |
📺 How to watch Tulane vs. Ole Miss: College Football Playoff
- Date: Saturday, Dec. 20
- Kickoff: 3:30 p.m. ET
- Location: Vaught-Hemingway Stadium (Oxford, Miss.)
- TV: TNT/HBO Max/truTV
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