Toledo vs. Louisville Predictions Today: 2025 Boca Raton Bowl Odds & Expert Picks

Our Toledo vs. Louisville predictions for the Boca Raton Bowl today side with the team that will have its top QB and head coach.
Louisville Cardinals quarterback Miller Moss (7) throws a pass as we break down our Toledo vs. Louisville predictions.
Pictured: Louisville Cardinals quarterback Miller Moss (7) throws a pass as we break down our Toledo vs. Louisville predictions. Photo by Brian Bishop / Imagn Images.
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While neither team enters the Boca Raton Bowl at full strength, my Toledo vs. Louisville predictions back the team that’s in better shape when it comes to roster retention.

Louisville is a 6.5-point betting favorite, with kickoff from Flagler Credit Union Stadium in Boca Raton, Fla., set for 2 p.m. ET (ESPN), as we dive into our college football best bets for the second bowl game featured in our college football predictions this week.

Stay ahead this bowl season with our updated college football bowl game odds and schedule.


🏈 Toledo vs. Louisville prediction: 2025 Boca Raton Bowl

Don't miss the rest of our college football picks for every bowl game.

Best bets Odds Confidence 
Louisville -7 -108 via DraftKings ⭐⭐⭐⭐
Miller Moss anytime TD +310 via FanDuel ⭐⭐⭐

Louisville -6.5 (-118) ⭐⭐⭐⭐

Toledo is depleted heading into the Boca Raton Bowl. Head coach Jason Candle left for UConn, defensive coordinator Vince Kehres left for Syracuse, and four key starters are in the transfer portal. Additionally, starting quarterback Tucker Gleason isn't expected to play.

So while Louisville is dealing with several injuries, the Cardinals are in better shape. Star pass-rusher Clev Lubin leads a Louisville defense poised to shut down a Rockets offense that's ranked just No. 70 by SP+, and that was with Gleason in the lineup.

Miller Moss should only need a handful of scoring drives to win this decisively. 

Score prediction: Louisville 26, Toledo 17

💡 More college football predictions

Want more college football betting advice? Check out all of our college football analysis and expert predictions for every bowl game.


πŸ™Œ Best Toledo vs. Louisville TD pick: Boca Raton Bowl

Search the best college football player prop odds for any team or player across every market from legal sportsbooks in your area.

Miller Moss, QB, Louisville: Anytime TD (+310) ⭐⭐⭐

If we knew what Louisville's running back situation would be today, the best TD bet would likely focus on the Cardinals' starting running back. But head coach Jeff Brohm has been playing coy about which of his top three running backs will be available.

While my best guess is Keyjuan Brown will play, his price to score is sitting at -185 (though I do like him to score twice at +290 via FanDuel). Instead, I think the best value is banking on Moss to score his 10th touchdown of the season.

💰️ Louisville TD SGP

It's not clear which running back will play for Louisville, but Brohm has implied he will have at least one of them. With Keyjuan Brown seemingly the most likely to play, I love parlaying him and Moss to both find the end zone against Toledo. An SGP on both to score is priced at +503 at FanDuel.

Although the USC transfer isn't much of a scrambler, he's a QB sneak connoisseur. Moss has tallied a rushing touchdown in eight of his 11 games this season, including in seven of his last eight and in three straight.


πŸ“ Top NFL draft prospects for Boca Raton Bowl

Can't keep track of which top players are suiting up this bowl season? Bookmark our college football opt-out tracker for the latest updates on every bowl game.

Player Position Key stats NFL draft grade
Emmanuel McNeil-Warren, Toledo SAF Allowing 50.3 NFL QB rating in coverage Round 1-2
Clev Lubin, Louisville EDGE 6th-most pressures in the country (59) Round 3-5
Caullin Lacy, Louisville WR 547 receiving yards, 674 return yards Round 5-7
Wesley Bailey, Louisville EDGE 7th-most pressures in the ACC (44) Round 6-UDFA
Avery Smith, Toledo CB 6th-most forced incompletions in the country (12) Round 6-UDFA
Chip Trayanum, Toledo RB 1,157 scrimmage yards, 13 TDs Round 7-UDFA

πŸ“Š Live Toledo vs. Louisville odds: Boca Raton Bowl

See the latest college football odds for every bowl game in real time.

Toledo vs. Louisville opening odds

  • Moneyline: Toledo +265 | Louisville -330
  • Spread: Toledo +8.5 (-110) | Louisville -8.5 (-110)
  • Over/Under: Over 44.5 (-110) | Under 44.5 (-110)

πŸ“ˆ Toledo vs. Louisville betting trends

Toledo Statistic Louisville
8-4 W-L record 8-4
9-3 ATS record 4-8
6-6 O/U record 5-7
6.3 Yards per play 6.0
3.9 Yards allowed per play 4.7
+0.5 Turnover margin +0.3
4-1 Last 5 games 2-3
W, 21-3 vs. Central Michigan Previous result W, 41-0 vs. Kentucky

πŸ€‘ Toledo vs. Louisville betting splits: Boca Raton Bowl

Betting insights via BetMGM.

Bet type % of bets % of handle
Toledo ML (+320) 40% 18%
Louisville ML (-425) 60% 82%
Toledo +10.5 29% 16%
Louisville -10.5 71% 84%
Over 43.5 81% 95%
Under 43.5 19% 5%

πŸ“Ί How to watch Toledo vs. Louisville: Boca Raton Bowl

  • Date: Tuesday, Dec. 23
  • Kickoff: 2 p.m. ET
  • Location: Flagler Credit Union Stadium (Boca Raton, Fla.)
  • TV: ESPN

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