Penn State vs. UCLA Prediction: Early Picks for Week 6 College Football Matchup
Last Updated: October 2, 2025 6:25 PM EDT • 3 minute read X Social Google News Link
My Penn State vs. UCLA prediction expects the Nittany Lions to bounce back against the Bruins in a one-sided affair.
Penn State is a 25.5-point betting favorite ahead of Saturday's 3:30 p.m. ET kickoff (CBS) at the Rose Bowl in Pasadena, and my college football picks expect Drew Allar and Co. to get right as a comfortable road favorite.
For more insights, our college football predictions for Week 6 provide detailed breakdowns and expert picks for all the biggest games.
🏈 Early Penn State vs. UCLA prediction & best bet
Stay ahead with the rest of our early college football predictions for Week 6.
🦁 Penn State -25.5 (-110) ⭐⭐⭐⭐
The Nittany Lions won each of their first three games by at least 34. The competition wasn’t stiff, but that won’t change Saturday, as the Bruins are averaging just 14.2 points per game while allowing 31.2.
Penn State is averaging 180.0 rushing yards per game. Between Kaytron Allen, Nicholas Singleton, and Drew Allar, the Nittany Lions are averaging 5.1 yards per carry. The Bruins are allowing 232.8 rushing yards per game and 5.4 yards per carry.
The visitors' defense has also been stout, holding opponents to no more than 11 points in any of their first three games. The Bruins’ implied total for this game is 12, but I don’t think they’ll get near that number, as they’ve already failed to hit it twice.
Most sites are in lockstep with BetMGM, offering Penn State -25.5 (-110). The price indicates a 53.28% chance of Penn State covering, and a winning $10 bet would profit $9.09.
📊 Penn State vs. UCLA odds: Week 6
Latest college football odds updated live in real time.
📈 Penn State vs. UCLA opening odds
- Moneyline: Penn State -4500 | UCLA +1600
- Spread: Penn State -25.5 (-110) | UCLA +25.5 (-110)
- Over/Under: Over 50.5 (-110) | Under 50.5 (-110)
💵 Penn State vs. UCLA betting splits
Latest odds and betting insights via BetMGM
| Bet type | Penn State | UCLA |
|---|---|---|
| Spread | 80% (-25.5) | 20% (+25.5) |
| Moneyline | 98% (-3000) | 2% (+1300) |
| Total | 81% (Over 49.5) | 19% (Under 49.5) |
🔍 Penn State vs. UCLA odds analysis
Penn State heads on the road for the first time this season, but UCLA has lost both of its home games by at least 25. I expect this number to potentially get as high as 28.5. If you're in on Penn State, you'll want to try to get in before this total hits four touchdowns, so that a 35-7 or similar result still covers.
As for the total, the number is set at 50.5. I think the number will go up slightly, if it moves, because of how bad the UCLA defense is. However, I’m staying away.
📺 How to watch Penn State vs. UCLA
- Date: Saturday, Oct. 4
- Kickoff: 3:30 p.m. ET
- Where: Rose Bowl (Pasadena, Calif.)
- TV: CBS
💡 College football Week 6 predictions
- Kentucky vs. Georgia prediction
- Air Force vs. Navy prediction
- Wisconsin vs. Michigan prediction
- Texas vs. Florida prediction
- Miami vs. Florida State prediction
- Penn State vs. UCLA prediction
- Boise State vs. Notre Dame prediction
- Vanderbilt vs. Alabama prediction
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