Ole Miss vs. Oklahoma Prediction, Picks & Odds: Who'll Win in College Football Week 9?

Can Ole Miss light up another top SEC defense, or will Oklahoma shut down Trinidad Chambliss?
Ole Miss vs. Oklahoma Prediction, Picks & Odds:
Pictured: Oklahoma Sooners quarterback John Mateer (10) passes against the South Carolina Gamecocks in the second half at Williams-Brice Stadium. Mandatory Credit: Jeff Blake-Imagn Images

My best Ole Miss vs. Oklahoma prediction and picks for Saturday’s noon ET (ABC) game at Memorial Stadium in Norman, Okla. focus on Oklahoma’s defensive strengths and offensive struggles. The Sooners are favored by between 4.5 and 5.5, as their second-ranked scoring defense tries to slow down Ole Miss’ high-powered offense.

Read on for my best college football picks for this game. And for more about this contest, check out our college football predictions for Week 9.


🏈 Ole Miss vs. Oklahoma prediction

College football picks for Week 9; odds subject to change.

  • Game prediction: Ole Miss +5 (-110 via Caesars) ⭐⭐⭐⭐
  • Over/Under pick: Under 54.5 (-110 via BetMGM) ⭐⭐⭐⭐

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🆚 Who will win Ole Miss vs. Oklahoma?

Oklahoma quarterback John Mateer has had turnover problems this season, throwing six interceptions in six games. Turnovers against Ole Miss would be deadly, as the Rebels rank 16th in points per game, scoring 37.4 per contest. But Ole Miss has just four takeaways this season, so I don’t expect the Rebels to take advantage of Oklahoma’s biggest weakness, leading to an Oklahoma win.


✅ Best Ole Miss vs. Oklahoma bet

🦈 Ole Miss +5 (-110) ⭐⭐⭐⭐

Oklahoma has the second-ranked scoring defense, allowing just 9.4 points per game. Yet, for as good as the defense has been, the offense is averaging just 28.7 points per game. While Oklahoma has still managed five wins by at least 11 points this season, the Ole Miss offense proved how strong they are by putting up 35 points against Georgia last week.

Chambliss will keep Ole Miss in this game

Trinidad Chambliss has eight touchdowns and just one interception this season. Last week, he threw for 263 yards and a touchdown against Georgia, while adding 42 yards and two touchdowns on the ground. Chambliss has already faced one top-10 defense this season. In that 24-19 win, he threw for 314 yards and one touchdown. 

Oklahoma is allowing just 213.0 yards per game. However, the offense has yet to score more than 26 points against a power conference opponent this season. And while Ole Miss struggles against the run, allowing 166.7 yards per game, the Oklahoma rushing attack has been incredibly inconsistent, averaging just 129.3 yards per game.

Caesars’ price of -110 implies a 52.38% chance Ole Miss covers. A $10 bet would pay $9.09.

⚖️ Ole Miss vs. Oklahoma score prediction: Oklahoma 27-Ole Miss 24

Track the latest college football scores for line movement and matchup info.

⬇️ Under 54.5 (-110) ⭐⭐⭐⭐

Ole Miss scoring 35 points against Georgia’s defense last week was very impressive, but Georgia is allowing 10 more points per game than Oklahoma this season. While Chambliss and the Ole Miss offense is one of the best in the country, the Rebels have scored 24 points twice this year, with one of those performances coming against LSU’s 10th-ranked scoring defense.

Oklahoma’s defense has allowed more than 17 points just once all season. The Sooners have held four opponents to fewer than 10 points. Considering how good the Oklahoma defense is, it wouldn’t be surprising to see Ole Miss held to a new season low. But Oklahoma’s offense isn’t good enough to light up a defense allowing 22.6 points per game.

BetMGM’s price of -110 implies a 52.38% chance that the Under hits. A $10 bet would profit $9.09.


⚖️ Ole Miss vs. Oklahoma score prediction: Oklahoma 27-Ole Miss 24

Track the latest college football scores for line movement and matchup info.

⬇️ Under 54.5 (-110) ⭐⭐⭐⭐

Ole Miss scoring 35 points against Georgia’s defense last week was very impressive, but Georgia is allowing 10 more points per game than Oklahoma this season. While Chambliss and the Ole Miss offense is one of the best in the country, the Rebels have scored 24 points twice this year, with one of those performances coming against LSU’s 10th-ranked scoring defense.

Oklahoma’s defense has allowed more than 17 points just once all season. The Sooners have held four opponents to fewer than 10 points. Considering how good the Oklahoma defense is, it wouldn’t be surprising to see Ole Miss held to a new season low. But Oklahoma’s offense isn’t good enough to light up a defense allowing 22.6 points per game.

BetMGM’s price of -110 implies a 52.38% chance that the Under hits. A $10 bet would profit $9.09.


📊 Ole Miss vs. Oklahoma odds

Latest college football odds updated live in real time.


📺 How to watch Ole Miss vs. Oklahoma

  • Date: Saturday, Oct. 25
  • Kickoff: Noon p.m. ET
  • Where: Memorial Stadium (Norman, Okla.)
  • TV: ABC

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