Oklahoma vs. Alabama Prediction & Opening Odds for College Football Week 12
Last Updated: November 10, 2025 8:22 PM EST • 2 minute read X Social Google News Link
My Oklahoma vs. Alabama prediction dives into the opening odds and key matchup trends as our early picks land on a definitive stance for this game total, which is set in the mid-40s as of Monday afternoon. The action for Oklahoma vs. Alabama kicks off from Bryant-Denny Stadium in Tuscaloosa, Ala., on Saturday at 3:30 p.m. ET (ABC).
Both defenses rank among the best in the country, which is a major factor in my early Oklahoma vs. Alabama picks as part of our college football Week 12 predictions.
🏈 Early Oklahoma vs. Alabama prediction & betting preview
Stay ahead with the rest of our early college football picks for Week 12.
⬇️ Under 46.5 (-115) ⭐⭐⭐⭐
Two of Alabama's three SEC home games have finished with fewer than 46.5 total points, with the shootout against Tennessee as the lone dissenting outcome. Oklahoma had similar barnburners against the Volunteers and Ole Miss, two teams with adjusted offensive efficiency metrics among the nation's top 12 - but their adjusted defensive efficiencies fall outside the top 30 nationally.
Oklahoma has otherwise engaged in lower-scoring affairs against all power conference opponents that rank higher in adjusted defensive metrics than offensive metrics. This applies to the Sooners' matchups with Michigan, Auburn, Texas and South Carolina -those four games went 4-0 to the Under.
FanDuel offers the best line early in the week with Under 46.5 at -115 odds. The implied probability at those odds is 53.49%, and the profit on a $10 bet would be $8.70.
💡 More Week 12 predictions
Want more college football betting advice? Check out all of our college football analysis and expert predictions for Week 12.
📊 Live Oklahoma vs. Alabama odds: Week 12
See the latest college football odds for every game in Week 12.
🔢 Oklahoma vs. Alabama opening odds
- Moneyline: Oklahoma +200 | Alabama -250
- Spread: Oklahoma +12.5 (-110) | Alabama -12.5 (-110)
- Over/Under: Over 56.5 (-110) | Under 56.5 (-110)
↔️ Oklahoma vs. Alabama line movement
Things opened up for this matchup a lot tighter than the early lookahead lines originally had expected, with Alabama at -6.5 to begin game week. That’s a line that should hold below a touchdown between two elite defenses.
These matchups trends suggest a lower-scoring outcome, which could lead to the total being bet down to the 44 or 44.5 range - a key number for totals given the potential for final scores of 24-20, 23-21 or 24-21, as examples.
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📈 Oklahoma vs. Alabama trends & betting notes
- Oklahoma games are 7-2 to the Under, tied for the fifth-best record in FBS
- Oklahoma and Alabama combine to allow just 32.7 points per game
- Oklahoma games against teams with top-30 adjusted defenses efficiency have averaged 35 total points per game
- Alabama’s defense ranks ninth in adjusted defensive efficiency
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📺 How to watch Oklahoma vs. Alabama
- Date: Saturday, Nov. 15
- Kickoff: 3:30 p.m. ET
- Location: Bryant-Denny Stadium (Tuscaloosa, Ala.)
- TV: ABC
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Brenden Schaeffer X social