Oklahoma State vs. Arizona Prediction: College Football Week 6 Odds & Expert Picks

Our best Oklahoma State vs. Arizona prediction has the Cowboys covering the spread while holding the Wildcats Under their team total.
Oklahoma State vs. Arizona Prediction: College Football Week 6 Odds, Expert Picks & Best Bets
Pictured: Arizona Wildcats defensive back Johno Price (21). Photo by Aryanna Frank via Imagn Images.

My best Oklahoma State vs. Arizona prediction highlights why the Cowboys are being undervalued ahead of Saturday’s 3 p.m. ET game (TNT, truTV, HBO Max) at Arizona Stadium in Tucson, Ariz. The Wildcats are favored by 20.5 points.

After Arizona’s terrible performance last weekend, oddsmakers have too much faith in them, as Oklahoma State is one of my best college football picks of the week. Below, I also explain why I expect Arizona to struggle a bit offensively, as part of my best college football predictions for Week 6.


🏈 Oklahoma State vs. Arizona predictions

College football expert picks for Week 6; odds subject to change.

  • Game pick: Oklahoma State +20.5 (-110 via BetMGM) ⭐⭐⭐⭐
  • Over/Under pick: Over 55.5 (-110 via bet365) ⭐⭐⭐⭐
  • Team prop bet: Arizona Under 37.5 points (-105 via DraftKings) ⭐⭐⭐⭐

✅ Oklahoma State vs. Arizona expert pick

Track the latest college football scores for line movement and matchup info.

🤠 Oklahoma State +20.5 (-110) ⭐⭐⭐⭐

Arizona blew out Hawaii and Weber State, but the Wildcats have struggled in two Big 12 games. They defeated 2-3 Kansas State by just six at home, and they were demolished by Iowa State 39-14.

Oklahoma State has struggled, but the Cowboys were competitive last week against Baylor, trailing by just eight entering the fourth quarter. Baylor put up 612 yards in that game, but Oklahoma State, which is averaging just 355.3 yards per game, finally came to life and managed 448 yards.

Noah Fifita and Arizona will score plenty, but Oklahoma State is a tougher opponent than the first two teams the Wildcats blew out. Zane Flores and Trent Howland will build off last week’s performance by doing enough offensively to keep Oklahoma State within three scores.

The best price available is -110 at BetMGM, which suggests a 52.38% chance that Oklahoma State covers. A $10 bet would pay $9.09.


💰 Best Oklahoma State vs. Arizona team prop bet

Our college football player prop odds tool shows the best odds for every market across legal sportsbooks in your area.

⬇️ Arizona Under 37.5 points (-105) ⭐⭐⭐⭐

Arizona put up at least 40 points in its first two games, but the Wildcats have managed just 37 in their last two combined. Oklahoma State has allowed at least 45 points in two of its four games. However, one of those games was against Oregon, and the other was against a Baylor team averaging 36.6 points per contest.

With this total, oddsmakers are essentially equating the Oklahoma State defense to Hawaii and Weber State. But this is a team allowing 420.3 yards and 23.3 points per game, if you remove the Cowboys' performance against No. 2 Oregon. Arizona is averaging 418 yards but just 31.2 points per game. This total is overvaluing Arizona's offensive capabilities.

DraftKings is offering this Under for -105, implying a 51.22% chance Oklahoma State holds Arizona below this number. A $10 bet would pay $9.52.


📊 Oklahoma State vs. Arizona odds

Latest college football odds updated live in real time.


📺 How to watch Oklahoma State vs. Arizona: Week 6

  • Date: Saturday, Oct. 4
  • Kickoff: 3 p.m. ET
  • Where: Arizona Stadium (Tucson, Ariz.)
  • TV: TNT/truTV, HBO Max

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