Ohio State vs. Washington Prediction: Odds & Expert Picks for College Football Week 5

One Big Ten team will be dealt its first loss of the season in this battle of 3-0 squads, and my Ohio State vs. Washington prediction backs the home underdogs against the nation's top-ranked school.

Ohio State is as high as an 8.5-point betting favorite, with kickoff from Husky Stadium set for 3:30 p.m. ET (CBS/Paramount+).

Along with the Huskies’ point spread as the first of my college football picks, I'm targeting a quarterback player prop at +152 as part of my college football predictions for Week 5.

📊 Ohio State vs. Washington odds

Latest college football odds updated live in real time.

🏈 Ohio State vs. Washington predictions

College football expert picks for Week 5; odds subject to change.

• Moneyline pick: Ohio State (-315 via bet365) ⭐⭐⭐⭐
• Against the spread pick: Washington +8.5 (-110 via DraftKings) ⭐⭐⭐⭐
• Over/Under pick: Over 51.5 (-110 via FanDuel) ⭐⭐

✅ Ohio State vs. Washington expert pick

Track the latest college football scores for line movement and matchup info.

🐺 Washington +8.5 (-110) ⭐⭐⭐⭐

Despite the early betting splits going 62% to 38% in Ohio State’s favor, the line has been shading toward Washington at the best sports betting sites, which isn’t surprising considering the home team has won 22 straight games in Seattle. I'm following that movement by backing the Huskies as my Ohio State vs. Washington best bet.

The Huskies rank in the top 10 among FBS teams in line yards, while the Buckeyes' defense sits 89th. And while Ohio State holds the advantage coming off a bye week, it's still fair to expect some jitters during Julian Sayin’s first collegiate road start.

Washington boasts one of the most underrated quarterback-running back tandems in the country with Demond Williams Jr. and Jonah Coleman. Williams is PFSN’s highest-graded quarterback thus far, and he's coming off an Apple Cup torching of Washington State, when he averaged +1.04 EPA per dropback while leading the team to an 87.5% conversion rate on third and fourth down.

The Huskies’ point spread has dipped as low as +8, so I'm taking advantage of the extra half-point at the standard -110 juice and 52.38% implied odds through DraftKings. A $10 winning wager would net $9.09 in profit if the home underdogs cover.

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💰 Ohio State vs. Washington player prop bet

Our college football player prop odds tool shows the best odds for every market across legal sportsbooks in your area.

⬇️ Julian Sayin, QB, Ohio State: Under 1.5 passing touchdowns (+152) ⭐⭐⭐

Sayin has built up some big-game experience through just three starts, as the team kicked the season off with a matchup against then-No. 1 Texas. But that game was at The Horseshoe, and this environment at Husky Stadium should add to a rocky start for the sophomore in his first road outing.

Washington leads the nation in pressure rate without blitzing. That will be a huge advantage for the Huskies, as it will allow them to drop more defenders into coverage to deal with the elite wide receiver tandem of Jeremiah Smith and Carnell Tate.

The Huskies also field one of the best safeties in Northern Arizona transfer Alex McLaughlin. He ranks third among 488 safeties in PFF’s coverage grade (minimum 50 coverage snaps), which should neutralize the threat of Ohio State’s downfield passing.

Sayin has logged seven touchdown passes over the last two weeks against weaker competition, but he notched only one against Texas. That makes these plus-money odds with a 39.68% implied probability desirable, and the +152 price at FanDuel trumps the +145 on the low end of the market. A $10 winning wager would net $15.20 in profit.

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