Ohio State vs. Illinois Prediction: Opening Odds & Early Picks for College Football Week 7

The public expects Illinois to cover as huge underdogs, but is Ohio State too much for the Fighting Illini?
Ohio State vs. Illinois Prediction: Opening Odds & Early Picks for College Football Week 7
Pictured: Ohio State Buckeyes defensive lineman Zion Grady (15) celebrates with defensive back Caleb Downs (2). Photo by Samantha Madar / Columbus Dispatch via Imagn Images.

My best Ohio State vs. Illinois prediction takes into account the opening odds for Saturday’s noon ET (FOX) game at Memorial Stadium in Champaign, Ill. Ohio State is favored by between 15.5 and 16.5 points, but the majority of early picks (70%) from the betting public back Illinois to cover.

My best early college football picks focus on the total for this game. Ohio State has given up just two touchdowns this season. Find out if I think the Illinois offense can decipher Ohio State’s defense in my college football predictions for Week 7.


🏈 Early Ohio State vs. Illinois prediction & best bet

Stay ahead with the rest of our early college football predictions for Week 7.

⬇️ Under 50.5 (-110) ⭐⭐⭐⭐

Ohio State has yet to give up more than nine points in a game this season. While Illinois has scored at least 34 in five of its six contests, it managed just 10 against Indiana. Ohio State has yet to face much of a test thus far, but it allowing just two touchdowns in five games is remarkable.

This isn’t a five-star play because Illinois is allowing 24 points per game. After Illinois allowed Indiana to score 63, it’s clear Ohio State could hit this Over on its own. However, the Buckeyes have scored more than 42 points just once, and that was against an FCS opponent.

BetMGM is offering Under 50.5 for -110. With 70% of bettors backing this Over, I expect this number to climb throughout the week, so you can wait to wager. A $10 bet would pay $9.09. The odds imply a $52.38% chance that this Under hits.


📺️ How to watch Ohio State vs. Illinois

When: Saturday, Oct. 11 @ noon ET

Where: Memorial Stadium (Champaign, Ill.)

TV: FOX


📊 Ohio State vs. Illinois odds: Week 7

Latest college football odds updated live in real time.

📈 Ohio State vs. Illinois opening odds

  • Moneyline: Ohio State -800 | Illinois +550
  • Spread: Ohio State -14.5 (-110) | Illinois +14.5 (-110)
  • Over/Under: Over 50.5 (-110) | Under 50.5 (-110)

💡 Ohio State vs. Illinois odds analysis

Despite the public backing Illinois, the spread has moved from 14.5 to as high as 16.5 at most major sportsbooks. This signals that oddsmakers are very confident in Ohio State in this game. Even if Illinois continues getting support, this spread will never drop to 14. The public will continue to back the Over, as Illinois has been involved in many high-scoring games, and Ohio State’s offense is averaging 37.4 points per game. So while I love Under 50.5, you’ll be able to get Under 51.5 or even 52.5 later in the week. 


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