College Football Predictions Today: Saturday's Best Bets & Odds for Biggest Games

We're treated to our fourth full Saturday slate of the season, and our college football predictions today have you covered for all of Week 4's marquee games.

Our college football picks offer comprehensive coverage of the moneyline, spread, Over/Under, and key player props for games such as Auburn vs. Oklahoma, Purdue vs. Notre Dame, and Michigan State vs. USC.

🏈 College football predictions for Week 4

Here are all of our college football expert picks for Week 4, which we'll update throughout the we

• Arizona State vs. Baylor prediction
• Washington vs. Washington State prediction
• Wyoming vs. Colorado prediction
• Michigan State vs. USC prediction
• Michigan State vs. USC player props
• Michigan State vs. USC anytime touchdown scorer predictions (coming soon)

💰 College football odds & expert picks: Saturday

📊 Arizona State vs. Baylor odds

• Date: Saturday, Sept. 20
• Kickoff: 7:30 p.m. ET
• Location: McLane Stadium (Waco, Texas)
• How to watch: FOX

🔮 Arizona State vs. Baylor prediction: Baylor -2.5

Here's a look at why Isaiah Sirois likes Baylor -2.5 as his Arizona State vs. Baylor prediction:

"The spread of 2.5 suggests that this is a pick’em on a neutral site. That gives way too much credit to an Arizona State squad that seems to have regressed year-over-year and clearly misses Cam Skattebo. It also doesn’t give enough credit to Baylor, especially after their gritty road win over SMU. With the Bears averaging a full yard per play more than the Sun Devils, I’m betting on them to cover the 2.5-point spread for -110 (52.4%) at FanDuel to score a $9.09 profit from a $10 bet."

📊 Washington vs. Washington State odds

• Date: Saturday, Sept. 20
• Kickoff: 7:30 p.m. ET
• Location: Martin Stadium (Pullman, Wash.)
• How to watch: CBS

🔮 Washington vs. Washington State prediction: Washington State +21

Here's a look at why Isaiah Sirois likes Washington State +21 in his Washington vs. Washington State prediction: 

"Twenty-one-point wins are uncommon in recent Apple Cup history. Washington State scored the most recent one in 2021. Washington’s biggest recent win in the series was a 27-point drubbing in 2016. While conference politics and the transfer portal have forever altered this series, I give some weight to the motivation with which Washington State will enter this game, especially with a successful former FCS coach in Jimmy Rogers at the helm."

📊 Wyoming vs. Colorado odds

• Date: Saturday, Sept. 20
• Kickoff: 10:15 p.m. ET
• Location: Folsom Field (Boulder, Colo.)
• How to watch: ESPN

🔮 Wyoming vs. Colorado prediction: Wyoming +14.5

Here's a look at why Mike Spector likes Wyoming +14.5 in his Wyoming vs. Colorado prediction:

"Wyoming’s rushing attack will be the key to staying close this week and keeping the Folsom Field crowd out of the game. Despite Colorado’s secondary being decimated with four key players out for last week’s loss to Houston, the Cougars elected to use their physical advantage up front and pounded the Buffaloes with 53 rushing attempts."

📊 Michigan State vs. USC odds

• Date: Saturday, Sept. 20
• Kickoff: 11 p.m. ET
• Location: Los Angeles Memorial Coliseum (Los Angeles)
• How to watch: FOX

🔮 Michigan State vs. USC prediction: Wyoming +14.5

Here's a look at why Brenden Schaeffer likes Over 55 as his best Michigan State vs. USC prediction:

"An efficient passing game is the Trojans’ calling card, which should lead to scoring for a USC side that enters this game averaging 55.0 points per game. If Michigan State contributes anything close to its 35.3 PPG average, this game should get Over a game total that has fallen by a half-point since it opened."

Most popular college football bets today

Here are the most popular college football Week 4 predictions at BetMGM as of Saturday morning:

💡 College football expert picks: Week 4

• College football picks against the spread Week 4
• College football player props Week 4
• College football moneyline parlay Week 4
• College football upsets picks Week 4
• College football best bets Week 4
• College football anytime touchdown scorer predictions Week 4
• College football AI predictions for Week 4

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