College Football Predictions 2025 Week 2: Odds & Best Bets for Top Matchups
Our college football predictions for Week 2 highlight some underrated matchups with a quieter slate on the heels of a loaded opening weekend. However, we are treated to an absolute banger in Michigan vs. Oklahoma.
Wolverines QB Bryce Underwood - one of the most anticipated QB recruits in recent member - will have his hands full in his first road start as he tries to keep up with Sooners Heisman Trophy odds contender John Mateer.
You won't want to miss our college football picks for that matchup, or any of the other games in Week 2.
🏈 College football predictions for Week 2
Here are all of our college football expert picks for Week 2, which we'll update throughout the week.
- James Madison vs. Louisville prediction (coming soon)
- Eastern Washington vs. Boise State prediction (coming soon)
- Iowa vs. Iowa State prediction (coming soon)
- Kent State vs. Texas Tech prediction (coming soon)
- Oklahoma State vs. Oregon prediction (coming soon)
- Ole Miss vs. Kentucky prediction (coming soon)
- Delaware vs. Colorado prediction (coming soon)
- Army vs. Kansas State prediction (coming soon)
- Michigan vs. Oklahoma prediction (coming soon)
- Michigan vs. Oklahoma player props (coming soon)
- Stanford vs. BYU prediction (coming soon)
💰 College football odds & expert picks: Week 2
Live college football odds for every Week 2 game; updated in real time.
📊 James Madison vs. Louisville odds
- Date: Friday, Sept. 5
- Kickoff: 7 p.m. ET
- Location: L&N Federal Credit Union Stadium (Louisville, Ky.)
- How to watch: ESPN
- Early pick: Louisville -14.5 (-108 via FanDuel)
Jeff Brohm has another portal QB, this time it's Miller Moss (USC). Moss is surrounded by explosive playmakers - Chris Bell, Isaac Brown, Caulin Lacy - who should help make his first start for the Cardinals go smoothly. Brohm also added several marquee defenders in the portal. Meanwhile, JMU's defense has a bunch of new faces (No. 77 in returning production) and a potential QB controversy.
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📊 Eastern Washington vs. Boise State odds
Odds not yet available for this matchup
- Date: Friday, Sept. 5
- Kickoff: 9 p.m. ET
- Location: Albertsons Stadium (Boise, Idaho)
- How to watch: FS1
📊 Iowa vs. Iowa State odds
- Date: Saturday, Sept. 6
- Kickoff: Noon ET
- Location: Jack Trice Stadium (Ames, Iowa)
- How to watch: FOX
- Early pick: Under 42 (-110 via Caesars)
Even with the addition of Mark Gronowski at QB, don't expect Iowa to become an offensive juggernaut. This is a team that will lean on its defense, which ranks No. 10 in SP+, much like Iowa State has with Domonique "Big Citrus" Orange anchoring the D-line. The battle for the Cy-Hawk Trophy hasn't cracked 40 points in three straight matchups.
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📊 Kent State vs. Texas Tech odds
- Date: Saturday, Sept. 6
- Kickoff: Noon ET
- Location: Jones AT&T Stadium (Lubbock, Texas)
- How to watch: TNT, HBO Max
📊 Oklahoma State vs. Oregon odds
- Date: Saturday, Sept. 6
- Kickoff: 3:30 p.m. ET
- Location: Autzen Stadium (Eugene, Ore.)
- How to watch: CBS, Paramount+
- Early pick: Oregon -27.5 (-110 via Caesars)
Oklahoma State's offense was a mess last season, and it already lost its new starting QB to injury in Week 1 (Hauss Hejny). Regardless of whether it's Hejny or Zane Flores, the Pokes are in trouble against an Oregon defense that ranks top 20 in SP+. The Ducks' offense shouldn't have any trouble either with Dante Moore and Makhi Hughes leading a group that sits fifth in SP+.
📊 Ole Miss vs. Kentucky odds
- Date: Saturday, Sept. 6
- Kickoff: 3:30 p.m. ET
- Location: Kroger Field (Lexington, Ky.)
- How to watch: ABC
📊 Delaware vs. Colorado odds
- Date: Saturday, Sept. 6
- Kickoff: 3:30 p.m. ET
- Location: Folsom Field (Boulder, Colo.)
- How to watch: FOX
📊 Army vs. Kansas State odds
- Date: Saturday, Sept. 6
- Kickoff: 7 p.m. ET
- Location: Bill Snyder Family Stadium (Manhattan, Kans.)
- How to watch: ESPN
📊 Michigan vs. Oklahoma odds
- Date: Saturday, Sept. 6
- Kickoff: 7:30 p.m. ET
- Location: Memorial Stadium (Norman, Okla.)
- How to watch: ABC
- Early pick: Oklahoma -4.5 (-110 via DraftKings)
The addition of John Mateer and his Washington State play-caller, Ben Arbuckle, should give the Sooners an offense that matches their talented defense. And while Michigan is poised for a bounce-back season, it's a big ask to expect true freshman Bryce Underwood to win in Norman in just his second start.
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📊 Stanford vs. BYU odds
- Date: Saturday, Sept. 6
- Kickoff: 10:15 p.m. ET
- Location: LaVell Edwards Stadium (Provo, Utah)
- How to watch: ESPN
💡 College football expert picks for Week 2
- College football picks against the spread Week 2 (coming soon)
- College football upsets picks Week 2 (coming soon)
- College football trends that matter Week 2 (coming soon)
- College football moneyline parlay Week 2 (coming soon)
- College football best bets Week 2 (coming soon)
- College football player props Week 2 (coming soon)
- College football predictions and picks Week 2 (coming soon)
- College football anytime touchdown scorer predictions Week 2 (coming soon)
- College football AI predictions for Week 2 (coming soon)
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