College Football Predictions Week 2: Best Bets & Odds for Top Matchups

Last Updated: September 6, 2025 10:21 AM EDT • 3 minute read X Social Google News Link

After an exciting opening weekend, our college football predictions for Week 2 highlight some of the sport's underrated matchups that are flying under the radar this weekend.
The lone ranked contest of Week 2 features Michigan vs. Oklahoma, a game that writes its own headlines. Wolverines signal-caller Bryce Underwood - one of the most significant recent QB recruits - faces a tough task in his first road start as he tries to keep up with Sooners Heisman Trophy odds contender John Mateer.
Don't miss our college football picks for that matchup, or any of the other games in Week 2.
🏈 College football predictions for Week 2
Here are all of our college football expert picks for Week 2, which we'll update throughout the week.
💰 College football odds & expert picks: Week 2
Live college football odds for every Week 2 game; updated in real time.
📊 Army vs. Kansas State odds
- Date: Saturday, Sept. 6
- Kickoff: 7 p.m. ET
- Location: Bill Snyder Family Stadium (Manhattan, Kans.)
- How to watch: ESPN
🔮 Army vs. Kansas State prediction: Avery Johnson Under 229.5 passing yards
Here's an excerpt from our Army vs. Kansas State prediction on why Philip Wood likes Avery Johnson to stay Under 229.5 passing yards
"I also worry that limited possessions will hurt Johnson, as the Black Knights proved last week that they can dominate time of possession even if they lose. And finally, Johnson was in tight contests in his first two games, which led to a lot of success through the air. This game won’t be close, and Johnson won’t be throwing much in the second half."
📊 Michigan vs. Oklahoma odds
- Date: Saturday, Sept. 6
- Kickoff: 7:30 p.m. ET
- Location: Memorial Stadium (Norman, Okla.)
- How to watch: ABC
🔮 Michigan vs. Oklahoma prediction: Oklahoma -4.5
Here's an excerpt from our Michigan vs. Oklahoma prediction on why Matt Jacob predicts Oklahoma to cover the spread against Michigan:
"This is more of a play against Michigan, which was not impressive at all in its 34-17 opening victory over lowly New Mexico. The Wolverines snagged three interceptions, racked up 456 total yards, and quadrupled the Lobos’ rushing total (201-50) - and yet still only won by 17 points against an opponent picked to finish 11th in a bad Mountain West Conference."
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📊 Stanford vs. BYU odds
- Date: Saturday, Sept. 6
- Kickoff: 10:15 p.m. ET
- Location: LaVell Edwards Stadium (Provo, Utah)
- How to watch: ESPN
🔮 Stanford vs. BYU prediction: BYU -20.5 (-110)
Here's an excerpt from our Stanford vs. BYU prediction on why Isaiah Sirois is backing the the Cougars at -20.5:
"While the BYU ground game was responsible for the Week 1 win, the passing game, with quarterback Bear Bachmeier leading the way, wasn’t an issue. Bachmeier completed 63.6% of his throws for 8.8 yards per attempt, and three touchdowns. With Stanford’s defense creating havoc just 10.8% of the time – and the defensive backs accounting for only 1.5% of that number – Bachmeier should excel through the air as well."
💡 College football expert picks for Week 2
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- College football AI predictions for Week 2
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