College Football Predictions for Every Top-25 Game: Week 10

There are 17 games involving ranked programs in Week 10, and we're making our college football predictions for every top-25 game this week, along with a score prediction and best bet.

While some of the college football games this week have lost their luster due to one team falling off, namely Penn State vs. No. 1 Ohio State, there are three top 25 matchups this week (Vanderbilt vs. Texas, Oklahoma vs. Tennessee, Cincinnati vs. Utah), and our college football Week 10 predictions have them all covered.

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🔮 College football predictions for Week 10

College football picks for every top-25 matchup based on the latest college football odds; subject to change.

🐅 No. 25 Memphis vs. Rice prediction

• When: Friday, Oct. 31 (7:30 p.m. ET, ESPN2)
• Best bet: Memphis -13.5 (-120 via FanDuel)

💰️ Score prediction: Memphis 33, Rice 17

After it appeared Memphis would be without star QB Brendon Lewis last week against South Florida, he miraculously suited up and led the Tigers to an upset victory to put them in the driver's seat for the Group of Six College Football Playoff spot. Ryan Silverfield has Memphis playing so well that he's rumored for a Power Four job. And despite Rice's improvements under Scott Abell, who runs a spread option offense, the Owls are on a 1-3 skid. 

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🌰 Penn State vs. No. 1 Ohio State prediction

• When: Saturday, Nov. 1 (noon ET, FOX)
• Best bet: Ohio State -20.5 (-110 via Caesars)

💰️ Score prediction: Ohio State 38, Penn State 10

This was supposed to be the biggest of noon kickoffs for FOX this season; instead, the network's choice of this game over Oregon vs. Penn State has backfired. The Nittany Lions have lost four straight, James Franklin is gone, and Drew Allar is done for the season. Ohio State should continue to cruise through weaker Big Ten opponents thanks to the nation's best defense, led by Arvell Reese and Caleb Downs. Meanwhile, QB Julian Sayin is playing at a Heisman level while throwing to Jeremiah Smith and Carnell Tate.

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⚓️ No. 9 Vanderbilt vs. No. 20 Texas prediction

• When: Saturday, Nov. 1 (noon ET, ABC)
• Best bet: Vanderbilt ML (+140 via Caesars)

💰️ Score prediction: Vanderbilt 27, Texas 26

Texas has won three straight games after its upset loss to Florida, but the last two came against SEC bottom-feeders, and the Longhorns still needed OT. And while Texas has underachieved all season, Vanderbilt has done the opposite behind Heisman contender Diego Pavia. The Commodores seem to fear nobody under head coach Clark Lea and have already won three ranked games this season. With Arch Manning potentially missing this matchup due to a concussion, can Steve Sarkisian's team do enough on offense to win?

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🌴 No. 10 Miami vs. SMU prediction

• When: Saturday, Nov. 1 (noon ET, ESPN)
• Best bet: Miami -11.5 (-118 via BetMGM)

💰️ Score prediction: Miami 33, SMU 20

It's been a hangover season for SMU after reaching the College Football Playoff last season, and it doesn't help that there are plenty of rumors that Rhett Lashlee will leave the Lone Star State to go home and take the Arkansas job. Miami doesn't have those same distractions after rebounding nicely from its upset loss to Louisville by beating Stanford 42-7 last week. With the best defensive player in the country on one side of the ball, Rueben Bain Jr., and the most dynamic freshman on the other side, Malachi Toney, the Canes shouldn't sweat this one on the road.

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🐾 West Virginia vs. No. 22 Houston prediction

• When: Saturday, Nov. 1 (noon ET, FS1)
• Best bet: Houston -13.5 (-110 via bet365)

💰️ Score prediction: Houston 40, West Virginia 17

You'd be hard-pressed to find a program builder who does it at the same level as Willie Fritz, who has Houston ranked in just his second season leading the Cougars. With a dual-threat QB in Conner Weigman and playmakers like Tanner Koziol and Dean Connors, Houston shouldn't have much trouble against a West Virginia program that may be regretting bringing back Rich Rodriguez. Houston also quietly has one of the best defensive lines in the country, led by Eddie Walls III.

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🔴 No. 16 Louisville vs. Virginia Tech prediction

• When: Saturday, Nov. 1 (3 p.m. ET, The CW)
• Best bet: Louisville -10.5 (-110 via Caesars)

💰️ Score prediction: Louisville 30, Virginia Tech 16

Thanks to Louisville's massive upset road win over No. 2 Miami two weeks ago, Brian Brohm's name is popping up for some major coaching openings. Despite the rumors that he could leave his alma mater, his players don't seem fazed as they push for a shot at the ACC Championship. And while Virginia Tech is coming off a win under interim head coach Philip Montgomery, the Hokies don't have the athleticism to compete with a team led by future NFL players like Isaac Brown, Chris Bell, and Clev Lubin. On the bright side, it sounds like James Franklin could end up in Blacksburg.

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⬇️ No. 2 Indiana vs. Maryland prediction

• When: Saturday, Nov. 1 (3:30 p.m. ET, CBS)
• Best bet: Under 51 (-110 via Caesars)

💰️ Score prediction: Indiana 34, Maryland 13

At this point, Indiana might not play a competitive football game until the Big Ten Championship. The Hoosiers have blown out every middling Big Ten opponent they've faced, and it shouldn't be much different against Maryland. Despite his impressive play, true freshman Malik Washington should be in over his head against Curt Cignetti's team. Indiana has held every opponent not named Oregon to 15 or fewer points this season. But Fernando Mendoza could take some time to get going against an underrated Terrapins front seven, led by freshman sensation Sidney Stewart.

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🐶 No. 5 Georgia vs. Florida prediction

• When: Saturday, Nov. 1 (3:30 p.m. ET, ABC)
• Best bet: Georgia -7.5 (-105 via BetMGM)

💰️ Score prediction: Georgia 27, Florida 17

Florida fans might need a few extra beverages at this year's World's Largest Outdoor Cocktail Party in Jacksonville. The Gators fired Billy Napier two weeks ago, and coming off a bye, they could get a spark from DJ Lagway and some of the young playmakers, but I don't see it being enough to keep this close. Gunner Stockton has Georgia's offense among the best in the country, and the Bulldogs have won the cocktail party in seven of the last eight seasons, including by at least 14 in four straight. Florida fans should just take solace in the fact that their governor isn't talking about the job opening like Jeff Landry is at LSU.

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☘️ No. 12 Notre Dame vs. Boston College prediction

• When: Saturday, Nov. 1 (3:30 p.m. ET, ESPN)
• Best bet: Notre Dame -28.5 (-110 via DraftKings)

💰️ Score prediction: Notre Dame 44, Boston College 13

Since opening the season with two losses, Notre Dame has beaten down on every opponent on its schedule. Marcus Freeman's team is five more wins against unranked teams away from getting into the College Football Playoff, and Bill O'Brien's Boston College team isn't going to have any answers for CJ Carr, Jeremiyah Love, and Jadarian Price. The Eagles have lost seven straight games after opening the season with a win over Fordham, an FCS program. Perhaps hiring former NFL head coaches past their prime isn't the best move for college programs?

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⬇️ No. 13 Texas Tech vs. Kansas State prediction

• When: Saturday, Nov. 1 (3:30 p.m. ET, FOX)
• Best bet: Under 53.5 (-125 via BetMGM)

💰️ Score prediction: Texas Tech 27, Kansas State 23

While Texas Tech gets starting QB Behren Morton back for this matchup, the pressure is on for the Red Raiders to win out to secure a spot in the Big 12 Championship. Rumor has it that if Joey McGuire can't get the roster funded by Cody Campbell to the CFP, he could be out of a job. Luckily, Texas Tech has far too much talent to drop another game if everyone is healthy. The Red Raiders' front seven should be the difference against Avery Johnson and Co., with pass-rusher David Bailey playing at an elite level right now.

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🐻 No. 15 Virginia vs. Cal prediction

• When: Saturday, Nov. 1 (3:45 p.m. ET, ESPN2)
• Best bet: Cal +4.5 (-105 via BetMGM)

💰️ Score prediction: Virginia 30, Cal 27

Virginia might be the luckiest team in the country at this point. The Cavaliers have gone to OT in three of their last four outings and won all three, including needing a failed 2-point attempt from North Carolina to beat Bill Belichick last week in overtime. Tony Elliott's team has won the last four games by a combined 14 points. So don't expect a blowout win on the road against a feisty Cal team that has a supertsar freshman QB in Jaron-Keawe Sagapolutele. The Hoos should fear the Calgorithm in this cross-country ACC battle.

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🦈 South Carolina vs. No. 7 Ole Miss prediction

• When: Saturday, Nov. 1 (7 p.m. ET, ESPN)
• Best bet: Ole Miss -12.5 (-110 via bet365)

💰️ Score prediction: Ole Miss 34, South Carolina 20

South Carolina just doesn't have the sauce this season, and that was clear when LaNorris Sellers fumbled against Alabama to end the Gamecocks' upset shot. Now this demoralized team has to hit the road and head to the Grove to take on an Ole Miss team that controlled the entirety of its win over Oklahoma. Lane Kiffin's name is popping up for seemingly every major head coaching opening, but it doesn't matter because the Rebels have the most complete offense they've ever had under him. Trinidad Chambliss should add to his Heisman campaign, while Sellers continues to try to do too much to make up for a lack of surrounding talent.

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〽️ Purdue vs. No. 21 Michigan prediction

• When: Saturday, Nov. 1 (7 p.m. ET, Big Ten Network)
• Best bet: Michigan -21 (-110 via BetMGM)

💰️ Score prediction: Michigan 36, Purdue 13

Sherrone Moore's team has rebounded nicely from its blowout loss to USC to take down Washington and Michigan State. With freshman QB Bryce Underwood, dynamic running back Justice Haynes, and a ferocious defense, the Wolverines should go berserker mode on a Purdue team that is 0-6 against Power Four opponents and has lost to ranked teams by an average margin of 21. Michigan is trending toward being 10-2 when it plays Ohio State on Nov. 29.

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⬆️ No. 8 Georgia Tech vs. NC State prediction

• When: Saturday, Nov. 1 (7:30 p.m. ET, ESPN2)
• Best bet: Over 58.5 (-110 via Caesars)

💰️ Score prediction: Georgia Tech 34, NC State 29

Georgia Tech is at the top of the ACC standings right now, and though it plays Georgia to close out the season, its final three conference matchups aren't overly difficult (NC State, Boston College, Pittsburgh). A loss to the Bulldogs won't affect the Yellow Jackets' shot at the ACC Championship, either. But can Haynes King continue to put this team on his back every week? It might be a down season for the Wolfpack, but there's talent in Raleigh with players like CJ Bailey, Hollywood Smothers, and Justin Joly. Keep an eye on a potential upset here.

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🅾️ No. 18 Oklahoma vs. No. 14 Tennessee prediction

• When: Saturday, Nov. 1 (7:30 p.m. ET, ABC)
• Best bet: Oklahoma +3.5 (-124 via FanDuel)

💰️ Score prediction: Oklahoma 29, Tennessee 27

Oklahoma clearly isn't as good as it looked during the first month of the season, with QB John Mateer struggling immensely since returning from thumb surgery. However, OU has a serious defense under Brent Venables, and R Mason Thomas is among the best pass-rushers in the country. Tennessee is the polar opposite, with Josh Heupel's veer and shoot thriving with Joey Aguilar at the helm, but the Volunteers' defense looks horrendous. Neither of these teams is going to the College Football Playoff, but this is going to be one of the most fun matchups of the weekend.

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🗡️ No. 23 USC vs. Nebraska prediction

• When: Saturday, Nov. 1 (7:30 p.m. ET, NBC)
• Best bet: Over 59 (-110 via Caesars)

💰️ Score prediction: USC 34, Nebraska 27

Well, Matt Rhule put the Penn State rumors to bed by signing an extension at Nebraska. Even so, the Cornhuskers continue to be one of the hardest teams to gauge in the country. Sometimes Dylan Raiola looks like Patrick Mahomes while playing like Matthew Stafford, and sometimes he just looks like Patrick Mahomes. He could play like his dad's old QB against an ugly USC defense, though. But in the end, Jayden Maiava, Makai Lemon, and Ja'Kobi Lane should win a shootout on the road. With all the major coaching firings lately and the willingness to pay massive buyouts, Lincoln Riley's seat could really heat up if he loses this game.

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🐈‍⬛ No. 17 Cincinnati vs. No. 24 Utah prediction

• When: Saturday, Nov. 1 (10:15 p.m. ET, ESPN)
• Best bet: Cincinnati +10.5 (-125 via BetMGM)

💰️ Score prediction: Utah 31, Cincinnati 23

The last game involving top 25 programs happens to be this week's College GameDay matchup. That means the campus in Salt Lake City will be lively at 6 a.m. local (PT) for a game that won't kick off until 7:15 p.m. local. A long day of tailgating for what should be a fun one between a Utah program that followed up its loss in the Holy War by stomping Colorado, and a Cincinnati team that's been a massive overachiever. While the Utes' defense and run game are among the best in the Big 12, Cincinnati is littered with NFL talent. Look for Brendan Sorsby, Joe Royer, Cyrus Allen, and Jake Golday to bring their best in front of NFL scouts.

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