College Football Predictions Week 7: Odds & Best Bets for Top Matchups
After a Saturday full of upsets, our college football predictions for Week 7 breakdown the odds for a loaded slate of can't-miss matchups and rivalry games.
Week 7's best college football picks include a top 25 SEC matchup between Alabama and Missouri, an Indiana vs. Oregon Big Ten showdown involving Heisman favorites, Arch Manning's first start in the Red River Rivalry, and a clash between historic programs (Michigan vs. USC).
🏈 College football predictions: Week 7
Here are all of our college football expert picks for Week 7, which we'll update throughout the week.
- Liberty vs. UTEP prediction (coming soon)
- East Carolina vs. Tulane prediction (coming soon)
- Southern Miss vs. Georgia Southern prediction (coming soon)
- South Florida vs. North Texas prediction (coming soon)
- Rutgers vs. Washington player props (coming soon)
- Early Ohio State vs. Illinois prediction (coming soon)
- Ohio State vs. Illinois prediction (coming soon)
- Ohio State vs. Illinois player props (coming soon)
- Early Alabama vs. Missouri prediction (coming soon)
- Alabama vs. Missouri prediction (coming soon)
- Alabama vs. Missouri player props (coming soon)
- Early Pittsburgh vs. Florida State prediction (coming soon)
- Pittsburgh vs. Florida State prediction (coming soon)
- Pittsburgh vs. Florida State player props (coming soon)
- Houston vs. Oklahoma State prediction (coming soon)
- Early Indiana vs. Oregon prediction (coming soon)
- Indiana vs. Oregon prediction (coming soon)
- Indiana vs. Oregon player props (coming soon)
- Early Oklahoma vs. Texas prediction (coming soon)
- Oklahoma vs. Texas prediction (coming soon)
- Oklahoma vs. Texas player props (coming soon)
- Oklahoma vs. Texas anytime touchdown scorer predictions (coming soon)
- Early Iowa State vs. Colorado prediction (coming soon)
- Iowa State vs. Colorado prediction (coming soon)
- NC State vs. Notre Dame prediction (coming soon)
- NC State vs. Notre Dame player props (coming soon)
- Florida vs. Texas A&M prediction (coming soon)
- Georgia vs. Auburn prediction (coming soon)
- Early Michigan vs. USC prediction (coming soon)
- Michigan vs. USC prediction (coming soon)
- Michigan vs. USC player props (coming soon)
- Michigan vs. USC anytime touchdown scorer predictions (coming soon)
- Kansas vs. Texas Tech prediction (coming soon)
- South Carolina vs. LSU prediction (coming soon)
- Arizona State vs. Utah prediction (coming soon)
💰 College football odds & expert picks: Wednesday
Here are the latest college football odds for every Week 7 game via the best college football betting sites, which update live in real time.
📊 Liberty vs. UTEP odds
- Date: Wednesday, Oct. 8
- Kickoff: 8 p.m. ET
- Location: Sun Bowl (El Paso, Texas)
- How to watch: CBSSN
💰 College football odds & expert picks: Thursday
📊 East Carolina vs. Tulane odds
- Date: Thursday, Oct. 9
- Kickoff: 7:30 p.m. ET
- Location: Yulman Stadium (New Orleans)
- How to watch: ESPN
📊 Southern Miss vs. Georgia Southern odds
- Date: Thursday, Oct. 9
- Kickoff: 8 p.m. ET
- Location: Allen E. Paulson Stadium (Statesboro, Ga.)
- How to watch: ESPN2
💰 College football odds & expert picks: Friday
📊 South Florida vs. North Texas odds
- Date: Friday, Oct. 10
- Kickoff: 7:30 p.m. ET
- Location: DATCU Stadium (Denton, Texas)
- How to watch: ESPN2
📊 Rutgers vs. Washington odds
- Date: Friday, Oct. 10
- Kickoff: 9 p.m. ET
- Location: Husky Stadium (Seattle)
- How to watch: FS1
💰 College football odds & expert picks: Saturday
📊 Ohio State vs. Illinois odds
- Date: Saturday, Oct. 11
- Kickoff: Noon ET
- Location: Memorial Stadium (Champaign, Ill.)
- How to watch: FOX
📊 Alabama vs. Missouri odds
- Date: Saturday, Oct. 11
- Kickoff: Noon ET
- Location: Memorial Stadium (Columbia, Mo.)
- How to watch: ABC
🔮 Early Alabama vs. Missouri prediction
🐘 Alabama -3.5 (-110)
Though Missouri has been one of the most slept on teams in the country this season, the Tigers are catching Alabama at a tough time. Crimson Tide QB Ty Simpson has been one of the best QBs in the nation, and running back Jam Miller is finally healthy - they have Alabama ranked No. 14 in SP+. Meanwhile, the Crimson Tide's defense has awoken in its last two top 25 matchups and now ranks top 10 in SP+. Alabama has the talent to pull away late.
📊 Pittsburgh vs. Florida State odds
- Date: Saturday, Oct. 11
- Kickoff: Noon ET
- Location: Doak Campbell Stadium (Tallahassee, Fla.)
- How to watch: ESPN
📊 Houston vs. Oklahoma State odds
- Date: Saturday, Oct. 11
- Kickoff: Noon ET
- Location: Boone Pickens Stadium (Stillwater, Okla.)
- How to watch: TNT, HBO Max
📊 Indiana vs. Oregon odds
- Date: Saturday, Oct. 11
- Kickoff: 3:30 p.m. ET
- Location: Autzen Stadium (Eugene, Ore.)
- How to watch: CBS
🔮 Early Indiana vs. Oregon prediction
⬇️ Under 55.5 (-115)
Both of these teams are led by Heisman-contending QBs, but don't forget these are also two of the best defenses in the country. These two units are top 10 in points allowed and combined to allow just 21.8 PPG. Both the Hoosiers and Ducks' defenses are full of future NFL players and rank top six in SP+, and neither allows more than 240 yards per game.
📊 Oklahoma vs. Texas odds
- Date: Saturday, Oct. 11
- Kickoff: 3:30 p.m. ET
- Location: Cotton Bowl (Dallas, Texas)
- How to watch: ABC
🔮 Early Oklahoma vs. Texas prediction
⬇️ Under 43 (-115)
The Red River Rivalry was supposed to play a huge role in the Heisman race this year; instead, John Mateer is out, and Arch Manning is bad. However, these two teams have elite defenses, with Oklahoma sitting No. 2 in SP+ and Texas ranked No. 4. Neither of these teams ranks top 20 in offense, and with Michael Hawkins Jr. starting, the Sooners might really struggle to score. This is going to be a slugfest at the State Fair of Texas.
📊 Iowa State vs. Colorado odds
- Date: Saturday, Oct. 11
- Kickoff: 3:30 p.m. ET
- Location: Folsom Field (Boulder, Colo.)
- How to watch: ESPN
📊 NC State vs. Notre Dame odds
- Date: Saturday, Oct. 11
- Kickoff: 3:30 p.m. ET
- Location: Notre Dame Stadium (Notre Dame, Ind.)
- How to watch: Peacock
📊 Florida vs. Texas A&M odds
- Date: Saturday, Oct. 11
- Kickoff: 7 p.m. ET
- Location: Kyle Field (College Station, Texas)
- How to watch: ESPN
📊 Georgia vs. Auburn odds
- Date: Saturday, Oct. 11
- Kickoff: 7:30 p.m. ET
- Location: Jordan-Hare Stadium (Auburn, Ala.)
- How to watch: ABC
📊 Michigan vs. USC odds
- Date: Saturday, Oct. 11
- Kickoff: 7:30 p.m. ET
- Location: Los Angeles Memorial Coliseum (Los Angeles)
- How to watch: NBC
🔮 Early Michigan vs. USC prediction
🗡️ USC -2.5 (+100)
These two programs couldn't be more different this season, with USC having a terrific offense and a struggling defense, and Michigan having an elite defense and an inconsistent offense. This is a bit of a toss-up, but the Trojans' offensive firepower should be the difference with Jayden Maiava, Makai Lemon, Ja'Kobi Lane, and Waymond Jordan having USC ranked No. 1 in SP+ on offense. Plus, a cross-country trip could be tough for Michigan freshman QB Bryce Underwood.
📊 Kansas vs. Texas Tech odds
- Date: Saturday, Oct. 11
- Kickoff: 7:30 p.m. ET
- Location: Jones AT&T Stadium (Lubbock, Texas)
- How to watch: FOX
📊 South Carolina vs. LSU odds
- Date: Saturday, Oct. 11
- Kickoff: 7:45 p.m. ET
- Location: Tiger Stadium (Baton Rouge, La.)
- How to watch: SEC Network
📊 Arizona State vs. Utah odds
- Date: Saturday, Oct. 11
- Kickoff: 10:15 p.m. ET
- Location: Rice-Eccles Stadium (Salt Lake City, Utah)
- How to watch: ESPN
💡 College football expert picks: Week 7
- College football picks against the spread Week 7 (coming soon)
- College football upsets picks Week 7 (coming soon)
- College football player props Week 7 (coming soon)
- College football anytime touchdown scorer predictions Week 7 (coming soon)
- College football best bets Week 7 (coming soon)
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