College Football Predictions & Odds Week 7: Best NCAAF Bets Today
Last Updated: October 11, 2025 12:11 PM EDT โข 3 minute read X Social Google News Link
Our college football predictions for Week 7 break down the latest odds for a loaded slate of can't-miss matchups and rivalry games across a four-day slate. We're looking ahead to the full Saturday slate, which kicks off at noon ET with Ohio State and Alabama both favored on the road against top-20 teams.
Week 7's best college football picks also feature Indiana vs. Oregon in a huge Big Ten battle between Heisman favorites, Arch Manning's first start in the Red River Rivalry between Texas and Oklahoma, and a clash between historic programs in Michigan and USC.
Wondering what games to watch? My college football week 7 viewing guide has you all taken care of.
๐ College football predictions: Week 7
Here are all of our college football expert picks for Week 7, which we'll update throughout the day with the latest odds and predictio
๐ฐ College football odds & expert picks: Saturday
Here are the latest college football odds for every Week 7 game via the best college football betting sites, which update live in real time.
๐ Ohio State vs. Illinois odds
- Date: Saturday, Oct. 11
- Kickoff: Noon ET
- Location: Memorial Stadium (Champaign, Ill.)
- How to watch: FOX
๐ฎ Ohio State vs. Illinois prediction
⬇️ Under 51 (-102)
Ohio State lost several key defensive starters to the NFL and defensive coordinator Jim Knowles to Penn State, and yet, this defense is just as good. That's a credit to the Buckeyes' recruiting and development, and Patricia's play-calling. Led by the best linebacker duo in the nation, Arvell Reese and Sonny Styles, and All-American safety Caleb Downs, the Buckeyes are No. 1 in SP+ on defense and allowing the fewest points per game in the nation (5.0).- via my Ohio State vs. Illinois prediction
๐ Alabama vs. Missouri odds
- Date: Saturday, Oct. 11
- Kickoff: Noon ET
- Location: Memorial Stadium (Columbia, Mo.)
- How to watch: ABC
๐ฎ Early Alabama vs. Missouri prediction
🐘 Alabama -3.5 (-110)
Though Missouri has been one of the most slept on teams in the country this season, the Tigers are catching Alabama at a tough time. Crimson Tide QB Ty Simpson has been one of the best QBs in the nation, and running back Jam Miller is finally healthy - they have Alabama ranked No. 14 in SP+. Meanwhile, the Crimson Tide's defense has awoken in its last two top 25 matchups and now ranks top 10 in SP+. Alabama has the talent to pull away late.
๐ Pittsburgh vs. Florida State odds
- Date: Saturday, Oct. 11
- Kickoff: Noon ET
- Location: Doak Campbell Stadium (Tallahassee, Fla.)
- How to watch: ESPN
๐ฎ Pittsburgh vs. Florida State prediction
🐾 Pittsburgh +10.5 (-110)
Freshman Mason Heintschel will make his second start for Pittsburgh after throwing for 323 yards and four touchdowns against Boston College. Heintschel and the Panthersโ pass-first offense, averaging 307 yards per game, will keep this close against a spiraling Florida State team.
- via Phil Wood's Pittsburgh vs. Florida State prediction
๐ Houston vs. Oklahoma State odds
- Date: Saturday, Oct. 11
- Kickoff: Noon ET
- Location: Boone Pickens Stadium (Stillwater, Okla.)
- How to watch: TNT, HBO Max
๐ Indiana vs. Oregon odds
- Date: Saturday, Oct. 11
- Kickoff: 3:30 p.m. ET
- Location: Autzen Stadium (Eugene, Ore.)
- How to watch: CBS
๐ฎ Indiana vs. Oregon prediction
🦆 Oregon -7.5 (-104)
Indiana is averaging 47.8 points, but it had just 10 against Iowa with 10 minutes remaining. I expect struggles to continue against a defense that allowed just four touchdowns in the first 19 quarters of the season.- via Phil Wood's Indiana vs. Oregon prediction
๐ Oklahoma vs. Texas odds
- Date: Saturday, Oct. 11
- Kickoff: 3:30 p.m. ET
- Location: Cotton Bowl (Dallas, Texas)
- How to watch: ABC
๐ฎ Oklahoma vs. Texas prediction
🅾️ Oklahoma ML (-108)
This matchup does not set up well for Manning and Co. - Oklahoma has the best pass defense in the country. The Sooners allow the second-fewest passing yards per game in college football (118.4), rank No. 1 in EPA per pass on defense, and lead the Power Four in sacks (21). Meanwhile, Manning has Texas sitting at No. 109 in EPA per pass on offense, with the 16th-lowest adjusted completion rate in the country (69%) and the fifth-highest turnover-worthy play rate nationally (6.7%).
- via my Oklahoma vs. Texas prediction
๐ Iowa State vs. Colorado odds
- Date: Saturday, Oct. 11
- Kickoff: 3:30 p.m. ET
- Location: Folsom Field (Boulder, Colo.)
- How to watch: ESPN
๐ฎ Iowa State vs. Colorado prediction
🦬 Colorado +2.5 (-105)
This matchup does not set up well for Manning and Co. - Oklahoma has the best pass defense in the country. The Sooners allow the second-fewest passing yards per game in college football (118.4), rank No. 1 in EPA per pass on defense, and lead the Power Four in sacks (21). Meanwhile, Manning has Texas sitting at No. 109 in EPA per pass on offense, with the 16th-lowest adjusted completion rate in the country (69%) and the fifth-highest turnover-worthy play rate nationally (6.7%).
- via Isaiah Sirois' Iowa State vs. Colorado prediction
๐ NC State vs. Notre Dame odds
- Date: Saturday, Oct. 11
- Kickoff: 3:30 p.m. ET
- Location: Notre Dame Stadium (Notre Dame, Ind.)
- How to watch: Peacock
๐ฎ NC State vs. Notre Dame prediction
⬇️ Under 58.5 (-110)
The Fighting Irish are averaging 178.6 rushing yards per game. While theyโre about to face a defense allowing just 131.8 rush yards per game, NC State did allow 174 rushing yards to Virginia Techโs Terion Stewart two weeks ago. Both of these teams have been involved in high-scoring games, but both defenses have clamped down of late. Notre Dame hasnโt allowed more than 13 points in either of its last two games, and NC State has held back-to-back opponents to 23 or less.
-via Phil Wood's NC State vs. Notre Dame prediction
๐ Florida vs. Texas A&M odds
- Date: Saturday, Oct. 11
- Kickoff: 7 p.m. ET
- Location: Kyle Field (College Station, Texas)
- How to watch: ESPN
๐ฎ Florida vs. Texas A&M prediction
🤠 Aggies -7.5 (-102)
Reedโs development has taken the offense to new heights, as he has 200 or more passing yards in every game this season after averaging 169.5 passing yards per game a season ago. But Texas A&M also showed its versatility last week, pulling away for a comfortable 22-point victory and cover as a 17.5-point favorite, despite Reed going 2-for-8 for 20 yards in the first quarter (his lowest yardage total in any quarter this season).
- via Mike Spector's Florida vs. Texas A&M prediction
๐ Georgia vs. Auburn odds
- Date: Saturday, Oct. 11
- Kickoff: 7:30 p.m. ET
- Location: Jordan-Hare Stadium (Auburn, Ala.)
- How to watch: ABC
๐ Michigan vs. USC odds
- Date: Saturday, Oct. 11
- Kickoff: 7:30 p.m. ET
- Location: Los Angeles Memorial Coliseum (Los Angeles)
- How to watch: NBC
๐ฎ Michigan vs. USC prediction
🗡️ USC ML (-135)
USCโs quarterback advantage, magnified by its home-field advantage, is the primary reason for this bet. Underwood has gone into hostile territory and struggled mightily through the air. Conversely, Maiava is better at home for his career (156.3 to 150.2) and with USC this year (234.9 to 149.1). Itโll be hard for Michigan to stop head coach Lincoln Rileyโs incredibly efficient passing attack, and itโll be even harder for the teamโs offense to keep up.- via Isaiah Sirois' Michigan vs. USC prediction
๐ Kansas vs. Texas Tech odds
- Date: Saturday, Oct. 11
- Kickoff: 7:30 p.m. ET
- Location: Jones AT&T Stadium (Lubbock, Texas)
- How to watch: FOX
๐ฎ Kansas vs. Texas Tech prediction
⬆️ Over 58.5 (-110)
Texas Tech has scored at least 34 points in every game this season, including two games with 60 or more points. โฆ Kansas enters this game averaging 35 points per contest. While the defense has been inconsistent, the offense has scored at least 27 points in all six games and topped 30 points five times.
- via Philip Wood's Kansas vs. Texas Tech prediction
๐ South Carolina vs. LSU odds
- Date: Saturday, Oct. 11
- Kickoff: 7:45 p.m. ET
- Location: Tiger Stadium (Baton Rouge, La.)
- How to watch: SEC Network\
๐ฎ South Carolina vs. LSU prediction
🐓 South Carolina +9 (-110)
Taking South Carolinaโs moneyline of +275 at BetMGM is a solid play, but taking South Carolina to cover 9 for -110 at Caesars is possibly the best play of the weekend. In three games against power conference teams, LSU has won just one game by more than nine. That came by defeating Florida 20-10, a game in which the defense forced five turnovers.
via Phil Wood's South Carolina vs. LSU prediction
๐ Arizona State vs. Utah odds
- Date: Saturday, Oct. 11
- Kickoff: 10:15 p.m. ET
- Location: Rice-Eccles Stadium (Salt Lake City, Utah)
- How to watch: ESPN
๐ฎ Arizona State vs. Utah prediction
🔴 Utah -7.5 (-115)
The rightful favorite in this matchup is the unranked team against the ranked squad, as Utah is in the top 20 nationally in both scoring offense and defense. Arizona State has been playing with fire with three of its last four games decided by four or fewer points, and the more talented team should win by a more comfortable margin this weekend. - via Mike Spector's Arizona State vs. Utah prediction
๐ก College football expert picks: Week 7
- College football picks against the spread Week 7
- College football upset picks Week 7
- College football predictions for every top 25 game
- College football player props Week 7
- College football anytime touchdown scorer predictions Week 7
- College football best bets Week 7
- College football Week 7 schedule: What to watch
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