College Football Predictions Week 6: Best Bets & Odds for Top Matchups
Coming off one of the best slates in recent memory last week, our college football predictions for Week 6 highlight the can't-miss games on the schedule this week as the season gets deeper and the chase to earn a College Football Playoff spot heats up.
Alabama looks to avenge last year's loss to Vanderbilt, Arch Manning makes his first SEC start of the season, and Florida State tries to bounce back at home against Miami as we cover all of the top college football matchups in Week 6.
🏈 College football predictions: Week 6
Check out all of our college football picks with live odds for Week 6.
- Sam Houston vs. New Mexico State prediction (coming soon)
- Sam Houston vs. New Mexico player props (coming soon)
- Charlotte vs. South Florida prediction (coming soon)
- West Virginia vs. BYU prediction (coming soon)
- West Virginia vs. BYU player props (coming soon)
- West Virginia vs. BYU anytime touchdown scorer predictions (coming soon)
- Early Kentucky vs. Georgia prediction (coming soon)
- Kentucky vs. Georgia prediction (coming soon)
- Kentucky vs. Georgia player props (coming soon)
- Early Wisconsin vs. Michigan prediction (coming soon)
- Wisconsin vs. Michigan prediction (coming soon)
- Wisconsin vs. Michigan player props (coming soon)
- Clemson vs. North Carolina prediction (coming soon)
- Clemson vs. North Carolina player props (coming soon)
- Early Air Force vs. Navy prediction (coming soon)
- Air Force vs. Navy prediction (coming soon)
- Oklahoma State vs. Arizona prediction (coming soon)
- Early Vanderbilt vs. Alabama prediction (coming soon)
- Vanderbilt vs. Alabama prediction (coming soon)
- Early Texas vs. Florida prediction (coming soon)
- Early Penn State vs. UCLA prediction (coming soon)
- Penn State vs. UCLA prediction (coming soon)
- Penn State vs. UCLA player props (coming soon)
- Early Boise State vs. Notre Dame prediction (coming soon)
- Boise State vs. Notre Dame prediction (coming soon)
- Boise State vs. Notre Dame player props (coming soon)
- Texas Tech vs. Houston prediction (coming soon)
- Early Miami vs. Florida State prediction (coming soon)
- Miami vs. Florida State prediction (coming soon)
- Miami vs. Florida State player props (coming soon)
- Miami vs. Florida State anytime touchdown scorer predictions (coming soon)
- Minnesota vs. Ohio State prediction (coming soon)
- Colorado vs. TCU prediction (coming soon)
- Colorado vs. TCU player props (coming soon)
- Colorado vs. TCU anytime touchdown scorer predictions (coming soon)
- Duke vs. California prediction (coming soon)
- Duke vs. California player props (coming soon)
💰 College football odds & expert picks: Thursday
Latest college football odds updated in real time for every game.
📊 Sam Houston vs. New Mexico State odds
- Date: Thursday, Oct. 2
- Kickoff: 9 p.m. ET
- Location: Aggie Memorial Stadium (Las Cruces, N.M.)
- How to watch: CBSSN
💰 College football odds & expert picks: Friday
📊 Charlotte vs. South Florida odds
- Date: Friday, Oct. 3
- Kickoff: 7 p.m. ET
- Location: Raymond James Stadium (Tampa, Fla.)
- How to watch: ESPN2
📊 West Virginia vs. BYU odds
- Date: Friday, Oct. 3
- Kickoff: 10:30 p.m. ET
- Location: LaVell Edwards Stadium (Provo, Utah)
- How to watch: ESPN
💰 College football odds & expert picks: Saturday
📊 Kentucky vs. Georgia odds
- Date: Saturday, Oct. 4
- Kickoff: Noon ET
- Location: Sanford Stadium (Athens, Ga.)
- How to watch: ABC
📊 Wisconsin vs. Michigan odds
- Date: Saturday, Oct. 4
- Kickoff: Noon ET
- Location: Michigan Stadium (Ann Arbor, Mich.)
- How to watch: FOX
🔮 Early Wisconsin vs. Michigan prediction
〽️ Michigan -16.5 (-110)
Wisconsin just isn't getting better under Luke Fickell, whose seat is as hot as ever after losing by 17 points to Maryland in Week 4 - the Badgers were a 10-point betting favorite in that game and are 1-3 ATS. Meanwhile, Michigan has covered in two straight games thanks to a defense that's ranked in the top 15 by SP+ and five-star freshman QB Bryce Underwood getting better each week.
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📊 Clemson vs. North Carolina odds
- Date: Saturday, Oct. 4
- Kickoff: Noon ET
- Location: Kenan Stadium (Chapel Hill, N.C.)
- How to watch: ESPN
📊 Air Force vs. Navy odds
- Date: Saturday, Oct. 4
- Kickoff: Noon ET
- Location: Navy-Marine Corps Memorial Stadium (Annapolis, Md.)
- How to watch: CBS, Paramount+
📊 Oklahoma State vs. Arizona odds
- Date: Saturday, Oct. 4
- Kickoff: 3 p.m. ET
- Location: Arizona Stadium (Tucson, Ariz.)
- How to watch: TNT, truTV, HBO Max
📊 Vanderbilt vs. Alabama odds
- Date: Saturday, Oct. 4
- Kickoff: 3:30 p.m. ET
- Location: Bryant-Denny Stadium (Tuscaloosa, Ala.)
- How to watch: ABC
🔮 Early Vanderbilt vs. Alabama prediction
⬆️ Over 56.5 (-110)
When Vanderbilt upset Alabama last year, and Diego Pavia announced himself as one of the best QBs in the country, these two programs combined for 75 points. This should be another high-scoring game with the level Pavia and Alabama QB Ty Simpson are playing at right now - Pavia is No. 3 in QBR (88.4) and Simpson is No. 12 (84.2). The two Heisman contenders lead offenses both ranked in the top 20 by SP+, and these two teams are a combined 6-3 betting the Over this year.
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📊 Texas vs. Florida odds
- Date: Saturday, Oct. 4
- Kickoff: 3:30 p.m. ET
- Location: Ben Hill Griffin Stadium (Gainesville, Fla.)
- How to watch: ESPN
🔮 Early Texas vs. Florida prediction
⬇️ Under 43.5 (-110)
While these two teams are led by two former five-star QBs that entered the season as Heisman contenders, neither has lived up to the hype. Instead, these two teams have been carried by their defenses this season, and their combined record of 7-1 betting the Under really highlights that. With the Longhorns having a top-five defense by SP+, and Florida's defense allowing just 21.3 points per game against ranked opponents this season, expect these two QBs to take their lumps again.
📊 Penn State vs. UCLA odds
- Date: Saturday, Oct. 4
- Kickoff: 3:30 p.m. ET
- Location: Rose Bowl (Pasadena, Calif.)
- How to watch: CBS
📊 Boise State vs. Notre Dame odds
- Date: Saturday, Oct. 4
- Kickoff: 3:30 p.m. ET
- Location: Notre Dame Stadium (Notre Dame, Ind.)
- How to watch: NBC
📊 Texas Tech vs. Houston odds
- Date: Saturday, Oct. 4
- Kickoff: 7 p.m. ET
- Location: TDECU Stadium (Houston)
- How to watch: ESPN
📊 Miami vs. Florida State odds
- Date: Saturday, Oct. 4
- Kickoff: 7:30 p.m. ET
- Location: Doak Campbell Stadium (Tallahassee, Fla.)
- How to watch: ABC
🔮 Early Miami vs. Florida prediction
🌴 Miami -5.5 (-110)
Florida State looked like the 2-10 team from last year when it gave Virginia an all-time field storming moment in Week 5, and now the Seminoles have to take on a surging Miami squad coming off a bye. The Hurricanes are by far the highest-ranked ACC team by SP+ (No. 12), led by a top-10 offense and a defense with the most disruptive pass rusher in the country, Rueben Bain Jr. While winning in Tallahassee isn't easy, the Hurricanes' trench play should be the difference on both sides.
📊 Minnesota vs. Ohio State odds
- Date: Saturday, Oct. 4
- Kickoff: 7:30 p.m. ET
- Location: Ohio Stadium (Columbus, Ohio)
- How to watch: NBC
📊 Colorado vs. TCU odds
- Date: Saturday, Oct. 4
- Kickoff: 7:30 p.m. ET
- Location: Amon G. Carter Stadium (Fort Worth, Texas)
- How to watch: FOX
📊 Duke vs. California odds
- Date: Saturday, Oct. 4
- Kickoff: 10:30 p.m. ET
- Location: California Memorial Stadium (Berkeley, Calif.)
- How to watch: ESPN
💡 College football expert picks: Week 6
- College football picks against the spread Week 6 (coming soon)
- College football player props Week 6 (coming soon)
- College football upsets picks Week 6 (coming soon)
- College football moneyline parlay Week 6 (coming soon)
- College football best bets Week 6 (coming soon)
- College football anytime touchdown scorer predictions Week 6 (coming soon)
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