College Football Predictions & Week 5 Best Bets: Today's Odds and Expert Picks
Last Updated: September 27, 2025 12:14 PM EDT โข 3 minute read X Social Google News Link
Saturday has finally rolled around, giving us perhaps the most thrilling and consequential of the entire college football season, and our college football predictions for Week 5 break down all the marquee matchups, including Oregon vs. Penn State and Alabama vs. Georgia.
With four top-25 showdowns, plus tough road tests for Ohio State and Texas A&M, college football Week 5 is packed with high-stakes action. Our expert college football picks cover all the key betting angles and storylines you need to know.
๐ College football predictions: Week 5
Here are all of our college football expert picks for Week 5, which we'll update throughout the week.
- Arizona vs. Iowa State prediction
- Oregon vs. Penn State prediction
- Alabama vs. Georgia prediction
- BYU vs. Colorado prediction
๐ฐ College football odds & expert picks today
Here are the latest college football odds for every Week 5 game via the best college football betting sites, which update live in real time.
๐ Arizona vs. Iowa State odds
- Date: Saturday, Sept. 27
- Kickoff: 7 p.m. ET
- Location: Jack Trice Stadium (Ames, Iowa)
- How to watch: ESPN
๐ฎ Arizona vs. Iowa State prediction: Arizona +6.5
Here's why Philip Wood is picking Arizona +6.5 in his Arizona vs. Iowa prediction:
"Arizona quarterback Noah Fifita hasnโt thrown an interception this season. If he takes care of the football again, then the Wildcats, who have a plus-2 turnover margin, can win this game."
๐ Oregon vs. Penn State odds
- Date: Saturday, Sept. 27
- Kickoff: 7:30 p.m. ET
- Location: Beaver Stadium (University Park, Pa.)
- How to watch: NBC
๐ฎ Oregon vs. Penn State prediction: Penn State -3
Here's why Mike Spector is predicting Penn State to cover the spread vs. Oregon in his Oregon vs. Penn State prediction:
"The switch in defensive coordinators at Penn State from Tom Allen to Jim Knowles, who was Ohio Stateโs defensive coordinator during last yearโs national championship run, has gone off without a hitch. Knowles has been aggressively deploying two of the best cover cornerbacks in the country in Jahmir Joseph and Daryus Dixson. That duo should help stifle an Oregon passing game that usually has huge advantages on the perimeter against weaker competition."
๐ Alabama vs. Georgia odds
- Date: Saturday, Sept. 27
- Kickoff: 7:30 p.m. ET
- Location: Sanford Stadium (Athens, Ga.)
- How to watch: ABC
๐ฎ Alabama vs. Georgia prediction: Alabama moneyline
Here's why I'm taking the Alabama moneyline in my Alabama vs. Georgia prediction:
"Neither of these teams has shown enough early in the season to believe they're capable of competing with the top teams in the country. With that said, Alabama has the talent to live up to the preseason hype of being a national title contender. This is a Crimson Tide squad that remains ranked top five in SP+ despite a Week 1 loss to Florida State that looks better a few weeks later. They're also one of only three teams to rank in the top 10 on offense and defense."
๐ BYU vs. Colorado odds
- Date: Saturday, Sept. 27
- Kickoff: 10:15 p.m. ET
- Location: Folsom Field (Boulder, Colo.)
- How to watch: ESPN
๐ฎ BYU vs. Colorado prediction: Over 47.5
Here's why Mike Spector is calling for Over 47.5 to hit in his BYU vs. Colorado prediction:
"The Over has cashed in four of BYUโs last five road games against unranked opponents. So even though the last meeting between these teams stayed Under the projected total of 54.5 points, I am banking on a rejuvenated Colorado offense to help cash the Over."
๐ก College football expert picks: Week 5
- College football picks against the spread Week 5
- College football player props Week 5
- College football moneyline parlay Week 5
- College football upsets picks Week 5
- College football best bets Week 5
- College football anytime touchdown scorer predictions Week 5
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Rob Paul X social