College Football Predictions Week 12: Best Bets & Odds for Top Matchups
As conference championship races heat up, this week's college football slate is full of massive matchups, and our college football predictions for Week 12 cover everything from ranked SEC clashes to major weeknight games - including our third week of MACtion.
This week, our college football picks feature two of the biggest games of the year - Oklahoma vs. Alabama and Texas vs. Georgia - an advantageous matchup for a top Heisman contender, Big 12 after dark, and much more.
🏈 College football predictions: Week 12
Here are all of our college football expert picks for Week 12, which we'll update throughout the week.
- Kent State vs. Akron prediction (coming soon)
- Ohio vs. Western Michigan prediction (coming soon)
- Buffalo vs. Central Michigan (coming soon)
- Northern Illinois vs. UMass (coming soon)
- Toledo vs. Miami (OH) (coming soon)
- Troy vs. Old Dominion prediction (coming soon)
- Clemson vs. Louisville prediction (coming soon)
- Clemson vs. Louisville player props (coming soon)
- Minnesota vs. Oregon prediction (coming soon)
- Minnesota vs. Oregon player props (coming soon)
- Notre Dame vs. Pitt prediction (coming soon)
- Early Oklahoma vs. Alabama prediction (coming soon)
- Oklahoma vs. Alabama prediction (coming soon)
- Oklahoma vs. Alabama player props (coming soon)
- Oklahoma vs. Alabama anytime touchdown scorer predictions (coming soon)
- Early Florida vs. Ole Miss prediction (coming soon)
- Florida vs. Ole Miss player props (coming soon)
- Early UCLA vs. Ohio State prediction (coming soon)
- UCLA vs. Ohio State prediction (coming soon)
- UCLA vs. Ohio State player props (coming soon)
- Julian Sayin player prop bets (coming soon)
- Early Texas vs. Georgia prediction (coming soon)
- Texas vs. Georgia prediction (coming soon)
- Texas vs. Georgia player props (coming soon)
- Texas vs. Georgia anytime touchdown scorer predictions (coming soon)
- Mississippi State vs. Missouri prediction (coming soon)
- TCU vs. BYU prediction (coming soon)
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💰 College football odds & expert picks: Tuesday
Here are the latest college football odds for every Week 12 game via the best college football betting sites, which update live in real time.
📊 Kent State vs. Akron odds
- Date: Tuesday, Nov. 11
- Kickoff: 7:30 p.m. ET
- Location: InfoCision Stadium (Akron, Ohio)
- How to watch: ESPNU
📊 Ohio vs. Western Michigan odds
- Date: Tuesday, Nov. 11
- Kickoff: 8 p.m. ET
- Location: Waldo Stadium (Kalamazoo, Mich.)
- How to watch: ESPN2
💰 College football odds & expert picks: Wednesday
📊 Buffalo vs. Central Michigan odds
- Date: Wednesday, Nov. 12
- Kickoff: 7 p.m. ET
- Location: Kelly/Shorts Stadium (Mount Pleasant, Mich.)
- How to watch: CBSSN
📊 Northern Illinois vs. UMass odds
- Date: Wednesday, Nov. 12
- Kickoff: 7 p.m. ET
- Location: Warren McGuirk Alumni Stadium (Amherst, Mass.)
- How to watch: ESPNU
📊 Toledo vs. Miami (OH) odds
- Date: Wednesday, Nov. 12
- Kickoff: 7 p.m. ET
- Location: Yager Stadium (Oxford, Ohio)
- How to watch: ESPN2
💰 College football odds & expert picks: Thursday
📊 Troy vs. Old Dominion odds
- Date: Thursday, Nov. 13
- Kickoff: 7:30 p.m. ET
- Location: S.B. Ballard Stadium (Norfolk, Va.)
- How to watch: ESPN
💰 College football odds & expert picks: Friday
📊 Clemson vs. Louisville odds
- Date: Friday, Nov. 14
- Kickoff: 7:30 p.m. ET
- Location: L&N Federal Credit Union Stadium (Louisville, Ky.)
- How to watch: ESPN
📊 Minnesota vs. Oregon odds
- Date: Friday, Nov. 14
- Kickoff: 9 p.m. ET
- Location: Autzen Stadium (Eugene, Ore.)
- How to watch: FOX
💰 College football odds & expert picks: Saturday
📊 Notre Dame vs. Pitt odds
- Date: Saturday, Nov. 15
- Kickoff: Noon ET
- Location: Acrisure Stadium (Pittsburgh)
- How to watch: ABC
🔮 Notre Dame vs. Pitt early prediction
🍀 Notre Dame Dame -10.5 (-110)
The ACC is so wide open that Pitt is still alive in the CFP race, but the Panthers have played only one truly competent program, Louisville. Pitt lost that game 34-27 at home, and while it found a spark in freshman QB Mason Heintschel since then, Notre Dame has beaten seven straight opponents by double digits. The Fighting Irish are 4-2-1 ATS since starting the season 0-2, and running back Jeremiyah Love should be able to carry Notre Dame's offense (No. 6 by SP+) against Pitt's defense (No. 33).
📊 Oklahoma vs. Alabama odds
- Date: Saturday, Nov. 15
- Kickoff: 3:30 p.m. ET
- Location: Bryant-Denny Stadium (Tuscaloosa, Ala.)
- How to watch: ABC
🔮 Oklahoma vs. Alabama early prediction
🐘 Alabama -6.5 (-110)
There might be no better QB in college football equipped to deal with Oklahoma's vaunted defense than Ty Simpson. He's playing quarterback at a different level right now with his pre-snap work, efficiency and accuracy, and aggressiveness as a downfield thrower. That should be the difference in this matchup with Oklahoma's John Mateer struggling as a passer since thumb surgery in late September. The Crimson Tide are the more well-rounded team, with a top-20 offense and a top-10 defense by SP+. If Oklahoma's defense doesn't get support from its offense, the Sooners will eventually crack against Simpson and his deep pass-catching corps.
📊 Florida vs. Ole Miss odds
- Date: Saturday, Nov. 15
- Kickoff: 7 p.m. ET
- Location: Vaught-Hemingway Stadium (Oxford, Miss.)
- How to watch: ESPN
📊 UCLA vs. Ohio State odds
- Date: Saturday, Nov. 15
- Kickoff: 7:30 p.m. ET
- Location: Ohio Stadium (Columbus, Ohio)
- How to watch: NBC
🔮 UCLA vs. Ohio State early prediction
🌰 Ohio State -30.5 (-110)
UCLA's dead cat bounce following the firing of DeShaun Foster has come to an end. The Bruins followed up their three-game winning streak by losing to Indiana by 50 and at home to a Nebraska team without its starting QB. This cross-country trip to Columbus won't go well for UCLA, with Ohio State having the best defense in the country and a lethal passing attack led by Heisman favorite Julian Sayin and star receiver Jeremiah Smith. The Buckeyes are one of just two teams ranked top 10 in the country on offense and defense by SP+, while the Bruins rank outside the top 65 in both.
📊 Texas vs. Georgia odds
- Date: Saturday, Nov. 15
- Kickoff: 7:30 p.m. ET
- Location: Sanford Stadium (Athens, Ga.)
- How to watch: ABC
🔮 Texas vs. Georgia early prediction
🐶 Georgia -5.5 (-110)
A rematch of last year's SEC Championship, this is the true test to see if Arch Manning has found his mojo. If the Longhorns lose, their CFP shot is basically over, and while Manning has looked far better in recent weeks, Texas has still struggled against lesser teams. Steve Sarkisian's team has beaten its last three opponents - Kentucky, Mississippi State, Vanderbilt - by a combined 13 points. Georgia, on the other hand, has an efficient offense with Gunner Stockton at the helm and a defense full of NFL talent. Georgia is 4-1 ATS since losing to Alabama, and Texas is just 1-4-1 ATS against Power Four teams.
📊 Mississippi State vs. Missouri odds
- Date: Saturday, Nov. 15
- Kickoff: 7:45 p.m. ET
- Location: Memorial Stadium (Columbia, Mo.)
- How to watch: SEC Network
📊 TCU vs. BYU odds
- Date: Saturday, Nov. 15
- Kickoff: 10:15 p.m. ET
- Location: LaVell Edwards Stadium (Provo, Utah)
- How to watch: ESPN
💡 College football expert picks: Week 12
- College football picks against the spread Week 12 (coming soon)
- MAC best bets Week 12 (coming soon)
- College football upsets picks Week 12 (coming soon)
- College football predictions for every top 25 game in Week 12 (coming soon)
- College football player props Week 12 (coming soon)
- Big Ten best bets Week 12 (coming soon)
- SEC best bets Week 12 (coming soon)
- College football Week 12 betting report (coming soon)
- College football anytime touchdown scorer predictions Week 12 (coming soon)
- Heisman Trophy power rankings Week 12 (coming soon)
- College football best bets Week 12 (coming soon)
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