College Football Predictions Week 10: Best Bets & Odds for Top Matchups
As the final few weeks of the regular season get underway, our college football predictions for Week 10 focus on several major matchups from Weekday CUSA to the Pac-2 showdown on Saturday night.
This week's college football picks focus heavily on No. 1 Ohio State's game against a Penn State team that's free-falling, Vanderbilt's ranked matchup against Texas, and the World's Largest Outdoor Cocktail Party between Georgia and Florida in Jacksonville.
🏈 College football predictions: Week 10
Here are all of our college football expert picks for Week 10, which we'll update throughout the week.
- UTEP vs. Kennesaw State prediction (coming soon)
- James Madison vs. Texas State prediction (coming soon)
- Jacksonville State vs. Middle Tennessee prediction (coming soon)
- FIU vs. Missouri State prediction (coming soon)
- Marshall vs. Coastal Carolina prediction (coming soon)
- Tulane vs. UTSA prediction (coming soon)
- Tulane vs. UTSA player props (coming soon)
- Memphis vs. Rice prediction (coming soon)
- North Carolina vs. Syracuse prediction (coming soon)
- North Carolina vs. Syracuse player props (coming soon)
- Sam Houston vs. Louisiana Tech prediction (coming soon)
- Early Penn State vs. Ohio State prediction (coming soon)
- Penn State vs. Ohio State prediction (coming soon)
- Penn State vs. Ohio State player props (coming soon)
- Penn State vs. Ohio State anytime touchdown scorer predictions (coming soon)
- Early Vanderbilt vs. Texas prediction (coming soon)
- Vanderbilt vs. Texas prediction (coming soon)
- Vanderbilt vs. Texas player props (coming soon)
- Early Army vs. Air Force prediction (coming soon)
- Army vs. Air Force prediction (coming soon)
- Early Georgia vs. Florida prediction (coming soon)
- Georgia vs. Florida prediction (coming soon)
- Georgia vs. Florida player props (coming soon)
- USC vs. Nebraska prediction (coming soon)
- USC vs. Nebraska player props (coming soon)
- Washington State vs. Oregon State prediction (coming soon)
- Cincinnati vs. Utah prediction (coming soon)
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💰 College football odds & expert picks: Tuesday
Here are the latest college football odds for every Week 10 game via the best college football betting sites, which update live in real time.
📊 UTEP vs. Kennesaw State odds
- Date: Tuesday, Oct. 28
- Kickoff: 8 p.m. ET
- Location: Fifth Third Stadium (Kennesaw, Ga.)
- How to watch: ESPNU
📊 James Madison vs. Texas State odds
- Date: Tuesday, Oct. 28
- Kickoff: 8 p.m. ET
- Location: UFCU Stadium (San Marcos, Texas)
- How to watch: ESPN2
💰 College football odds & expert picks: Wednesday
📊 Jacksonville State vs. Middle Tennessee odds
- Date: Wednesday, Oct. 29
- Kickoff: 7:30 p.m. ET
- Location: Johnny "Red" Floyd Stadium (Murfreesboro, Tenn.)
- How to watch: ESPN2
📊 FIU vs. Missouri State odds
- Date: Wednesday, Oct. 29
- Kickoff: 8 p.m. ET
- Location: Robert W. Plaster Stadium (Springfield, Mo.)
- How to watch: CBSSN
💰 College football odds & expert picks: Thursday
📊 Marshall vs. Coastal Carolina odds
- Date: Thursday, Oct. 30
- Kickoff: 7:30 p.m. ET
- Location: Brooks Stadium (Conway, S.C.)
- How to watch: ESPN2
📊 Tulane vs. UTSA odds
- Date: Thursday, Oct. 30
- Kickoff: 7:30 p.m. ET
- Location: Alamodome (San Antonio, Texas)
- How to watch: ESPN
💰 College football odds & expert picks: Friday
📊 Memphis vs. Rice odds
- Date: Friday, Oct. 31
- Kickoff: 7 p.m. ET
- Location: Rice Stadium (Houston)
- How to watch: ESPN2
📊 North Carolina vs. Syracuse odds
- Date: Friday, Oct. 31
- Kickoff: 7:30 p.m. ET
- Location: JMA Wireless Dome (Syracuse, N.Y.)
- How to watch: ESPN
📊 Sam Houston vs. Louisiana Tech odds
- Date: Friday, Oct. 31
- Kickoff: 8 p.m. ET
- Location: Joe Aillet Stadium (Ruston, La.)
- How to watch: CBSSN
💰 College football odds & expert picks: Saturday
📊 Penn State vs. Ohio State odds
- Date: Saturday, Nov. 1
- Kickoff: Noon ET
- Location: Ohio Stadium (Columbus, Ohio)
- How to watch: FOX
🔮 Penn State vs. Ohio State early prediction
🌰 Ohio State -20.5 (-110)
Last year, this was a matchup between top-five teams, with Ohio State winning by seven on the road. This year, it's in Columbus, and Penn State has completely fallen apart, firing James Franklin and losing four straight games. With the Buckeyes having the No. 1-ranked defense by SP+ and an offense led by Heisman contender Julian Sayin, the Nittany Lions don't stand a chance on the road with backup freshman QB Ethan Grunkemeyer behind center. The Buckeyes enter this game 6-0-1 ATS, while Penn State is just 1-6.
📊 Vanderbilt vs. Texas odds
- Date: Saturday, Nov. 1
- Kickoff: Noon ET
- Location: DKR-Texas Memorial Stadium (Austin, Texas)
- How to watch: ABC
🔮 Vanderbilt vs. Texas early prediction
⚓️ Vanderbilt +2.5 (-110)
While Texas' comeback OT win against Mississippi State in Week 9 was impressive, it was still a game the Longhorns failed to cover the spread in ... they're now 2-6 ATS. Meanwhile, Vanderbilt took down a ranked Missouri team to lift its ATS record to 6-2. With Arch Manning exiting Texas' win over the Bulldogs with a concussion, there's no guarantee he'll be able to play against the Commodores either. Back Diego Pavia to keep this close on the road with these teams both being ranked top 15 by SP+. Vanderbilt is 4-0 ATS this season when the spread is single digits either way.
📊 Army vs. Air Force odds
- Date: Saturday, Nov. 1
- Kickoff: Noon ET
- Location: Falcon Stadium (USAF Academy, Co.)
- How to watch: CBS, Paramount+
📊 Georgia vs. Florida odds
- Date: Saturday, Nov. 1
- Kickoff: 3:30 p.m. ET
- Location: EverBank Stadium (Jacksonville, Fla.)
- How to watch: ABC
🔮 Georgia vs. Florida early prediction
🐶 Georgia -7.5 (+100)
While the World's Largest Outdoor Cocktail Party has one of the best rivalry game names in sports, the game itself hasn't been that good in recent years. Since Kirby Smart took over in Athens, Georgia is 7-2 against Florida and has won four straight matchups, all four of them by at least 14 points. That shouldn't change against a Florida team that just fired Billy Napier and is ranked No. 63 on offense by SP+. Gunner Stockton and Co. should beat Florida by more than a touchdown to extend the Bulldogs' ATS streak to 4-0 since the start of October. Florida is just 1-5 ATS against FBS opponents.
📊 USC vs. Nebraska odds
- Date: Saturday, Nov. 1
- Kickoff: 7:30 p.m. ET
- Location: Memorial Stadium (Lincoln, Neb.)
- How to watch: NBC
🔮 USC vs. Nebraska early prediction
🗡️ USC -4.5 (-110)
While the rumor mill keeps churning about Matt Rhule taking the head coaching job at his alma mater, Penn State, Nebraska continues to look unimpressive. The Cornhuskers are 0-4-1 ATS in Big Ten games this season, and are just a few weeks removed from getting blown out by a Minnesota team that just lost by 38 to Iowa. As for USC, it's poised to bounce back off a bye week after losing to Notre Dame in Week 8. The Trojans are ranked No. 1 in the country in offense by SP+ thanks to Jayden Maiava and Makai Lemon, and have covered in two straight games against ranked teams.
📊 Washington State vs. Oregon State odds
- Date: Saturday, Nov. 1
- Kickoff: 7:30 p.m. ET
- Location: Reser Stadium (Corvallis, Ore.)
- How to watch: CBS
📊 Cincinnati vs. Utah odds
- Date: Saturday, Nov. 1
- Kickoff: 10:15 p.m. ET
- Location: Rice-Eccles Stadium (Salt Lake City)
- How to watch: ESPN
💡 College football expert picks: Week 10
- College football picks against the spread Week 10 (coming soon)
- College football early lines & look-ahead odds (coming soon)
- College football player prop picks Week 10: Weekday best bets (coming soon)
- College football predictions for every top 25 game in Week 10 (coming soon)
- College football player props Week 10 (coming soon)
- Big Ten best bets Week 10 (coming soon)
- SEC best bets Week 10 (coming soon)
- College football betting report Week 10 (coming soon)
- College football anytime touchdown scorer predictions Week 10 (coming soon)
- College football Week 10 schedule & watch guide (coming soon)
- College football best bets Week 10 (coming soon)
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