College Football Moneyline Picks Week 8: Best ML Bets, 10-Leg Parlay This Week

Our 10-leg college football moneyline parlay pays out at nearly 20/1 as we look ahead to the Week 8 slate.
College Football Moneyline Picks Week 8: Best ML Predictions & Parlay Bets
Pictured: Vanderbilt quarterback Diego Pavia (2) runs in a touchdown past Utah State cornerback Noah Avinger (1). Photo by Andrew Nelles / The Tennessean via Imagn Images.

My college football moneyline picks are back as we dive into our college football predictions for Week 8, combining 10 of our favorite moneyline wagers into one massive parlay that can keep you sweating all weekend long.

Our college football picks for the +1929 parlay begin on Friday night with Miami and California as ACC home favorites against outclassed opponents.

From there, we take stands on some of the biggest games from the SEC and Big Ten, while deciding whether Notre Dame passes one of its biggest remaining tests on its nomadic schedule.


🏈 College football moneyline picks: Week 8

College football moneyline picks for Week 8; odds subject to change.

  • Miami (-530 via FanDuel) vs. Louisville (Fri.) ⭐⭐⭐⭐⭐
  • California (-395 via DraftKings) vs. North Carolina (Fri.) ⭐⭐⭐⭐⭐
  • Vanderbilt (-132 via FanDuel) vs. LSU ⭐⭐⭐⭐⭐
  • Northwestern (-162 via FanDuel) vs. Purdue ⭐⭐⭐⭐
  • Indiana (-4000 via Caesars) vs. Michigan State ⭐⭐⭐⭐⭐
  • Florida (-345 via FanDuel) vs. Mississippi State ⭐⭐⭐⭐
  • Oregon (-800 via DraftKings) at Rutgers ⭐⭐⭐⭐
  • Alabama (-310 via FanDuel) vs. Tennessee ⭐⭐⭐⭐⭐
  • Notre Dame (-300 via FanDuel) vs. USC ⭐⭐⭐⭐⭐
  • Missouri (-110 via FanDuel) at Auburn ⭐⭐⭐⭐

Best parlay odds: +1929 via FanDuel ($10 to win $192.96)

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💰 Best college football moneyline picks to parlay

Here are my favorite moneyline picks and best bets for Week 8 based on the best college football odds for the full parlay.

🚀 Vanderbilt (-132) ⭐⭐⭐⭐⭐

I still have LSU on fraud watch as the paper Tigers haven’t beaten a power conference opponent with a winning record yet.

Vandy is still licking its wounds from its most recent loss at Alabama, but the Commodores have been dominant at home, going 2-1 ATS and boasting an average margin of victory of 37 points per game.

That’s problematic for an LSU team averaging just 19.8 PPG against FBS competition. LSU has racked up its wins against offenses outside the top 50 in adjusted efficiency per FPI, and it lost against Ole Miss, which ranks 23rd in AdjO. Vanderbilt ranks No. 1 in the nation in the metric.


🚀 Northwestern (-162) ⭐⭐⭐⭐

Northwestern suddenly has some momentum after logging a road win at Penn State this past week. The Wildcats are 3-1 in home games, with the only loss coming against Oregon in a 34-14 final to cover the 27.5-point spread.

Purdue has lost road games by seven points at Minnesota and by 26 points at Notre Dame this season, failing to cover the spread in either outcome. The Boilermakers haven’t won a conference road game since November 2022.

If Northwestern - which just won a conference road game at Penn State two days ago - can’t keep Purdue in its place, then I know absolutely zero about the hierarchy within the Big Ten at this point.


🚀 Missouri (-110) ⭐⭐⭐⭐

This is a proving ground spot for Eli Drinkwitz’s tenure at Missouri after the Tigers struggled to get over the hump in marquee road games last season. The edge for Missouri comes from the potency of its offense, which averages 37.8 PPG overall and 31.6 PPG against power conference opponents.

Auburn has fallen short of its own signature win in three straight weeks, scoring just 37 points over three straight conference losses. Jackson Arnold hasn’t demonstrated the passing chops to take advantage of the lone weakness in Missouri’s defense, so I don’t expect Auburn to keep pace in this one, even at home.


💰 Best college football Week 8 parlay odds

Our parlay calculator shows the best odds for every market across legal sportsbooks in your area.


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