College Football Moneyline Parlay Picks: Best Week 4 Predictions at +1169 Odds

Last Updated: September 20, 2025 11:18 AM EDT • 4 minute read X Social Google News Link

In Week 3, we finally hit paydirt with our college football moneyline parlay picks. Underdogs Georgia Tech and Vanderbilt served as the anchors of our college football picks as we cashed the moneyline parlay with +1125 odds.
Our college football predictions for Week 4 will take a similar approach, but instead of backing a pair of slight underdogs to juice up our parlay, we’re changing up the gameplan by putting our weight behind only one notable dog in a Top 25 matchup.
With this team checking in at +210 on the moneyline from Caesars, it’s an important piece in boosting our parlay odds to +1169. Read below to learn which team we view as the key to this week’s parlay.
🏈 College football moneyline parlay picks: Week 4
College football parlay picks odds subject to change.
- Clemson (-714 via Caesars) vs. Syracuse ⭐⭐⭐⭐
- Oklahoma (-250 via Caesars) vs. Auburn ⭐⭐⭐⭐⭐
- Ole Miss (-417 via Caesars) vs. Tulane ⭐⭐⭐⭐
- Mississippi State (-2500 via Caesars) vs. Northern Illinois ⭐⭐⭐⭐
- Georgia Tech (-2000 via Caesars) vs. Temple ⭐⭐⭐⭐
- Kansas (-470 via Caesars) vs. West Virginia ⭐⭐⭐⭐
- Miami (-320 via DraftKings) vs. Florida ⭐⭐⭐⭐⭐
- Vanderbilt (-4500 via DraftKings) vs. Georgia State ⭐⭐⭐⭐⭐
- Illinois (+210 via DraftKings) at Illinois ⭐⭐⭐⭐⭐
- Cal (-476 via Caesars) at San Diego State ⭐⭐⭐⭐
Best parlay odds: +1169 via Caesars ($10 to win $116.98)
💰 Best college football moneyline picks to parlay
Here are my favorite moneyline picks and best bets for Week 4 based on the best college football odds for the full parlay.
🚀 Oklahoma (-250) ⭐⭐⭐⭐⭐
As Jackson Arnold returns to Norman, Oklahoma is a touchdown favorite over Auburn in a game that could be a real sweat on the spread, but I see Oklahoma having too much firepower inside a charged-up Gaylord Family Memorial Stadium.
The Sooners are 13th in FPI’s Power Index and rank among the nation’s top 10 in overall adjusted efficiency, with a slight edge over Auburn in those categories.
Oklahoma’s run defense (allowing 86.0 yards per game) should neutralize Arnold’s legs and force him to beat his old team with his arm. I’m not convinced he can do it.
🚀 Miami (-320) ⭐⭐⭐⭐⭐
Here’s another game that I would be hesitant to bet against the spread (Miami -8.5) but within our moneyline parlay, Miami has more margin for error against a mistake-prone Gator offense.
In two games against FBS foes, Florida has compiled just 26 total points (13.0 PPG). That version of the Gator offense, which Miami can force to be one-dimensional given the Hurricanes’ prowess against the run (75.0 rushing yards per game against), simply won’t be able to keep pace with Miami’s offense.
The Canes are averaging 38.0 PPG against FBS opponents.
🚀 Illinois (+205) ⭐⭐⭐⭐⭐
As Curt Cignetti’s profile was inexplicably launched into a national platform, the college football community was seemingly content to ignore the elephant in the room: by the conclusion of the 2024 season, Indiana had played a grand total of two teams with a pulse, losing those games by a combined 33 points.
We don’t know how good Illinois is, but pretending the Hoosiers have some sort of edge because of their ability to hang 70 on an FCS school is foolhardy. This game should be a pick'em, and it's not. So, we’re using Illinois at +205 to unlock upside for our parlay.
Most popular college football bets today
Here are the most popular college football Week 4 predictions at BetMGM as of Saturday morning:
Most bet games (tickets) | Most bet teams (tickets) | Most bet teams (handle) | Most bet totals (tickets) |
---|---|---|---|
Texas Tech at Utah | Oklahoma -6.5 | Texas -39.5 | Texas Tech at Utah Over 57.5 |
Michigan at Nebraska | Utah -3.5 | Oklahoma -6.5 | Auburn at Oklahoma Over 46.5 |
Auburn at Oklahoma | Miami -7.5 | Utah -3.5 | Michigan at Nebraska Over 47.5 |
Illinois at Indiana | Michigan -1.5 | Miami -7.5 | Oregon State at Oregon Over 56.5 |
Florida at Miami | Illinois +7 | Nebraska +1.5 | Kent State at Florida State Over 55.5 |
❓ College football moneyline parlay FAQs
What are the best college football moneyline parlay picks this week?
Our best college football moneyline parlay picks this week include Clemson (-714 via Caesars), Oklahoma (-250 via Caesars), Ole Miss (-417 via Caesars), Mississippi State (-2500 via Caesars), Georgia Tech (-2000 via Caesars), Kansas (-470 via West Virginia), Miami (-320 via DraftKings), Vanderbilt (-4500 via DraftKings), Illinois (+210 via DraftKings) and Cal (-476 via Caesars) for a combined parlay odds at Caesars of +1169.
What is a parlay bet in college football?
A parlay combines multiple bets (spreads, totals, props, or moneylines) into one wager, with all selections needing to win for the bet to cash. Parlays are popular in college football betting because they offer bigger payouts.
How do college football parlay odds work?
Parlay odds are calculated by multiplying the odds of each individual selection, which increases both the potential payout and the risk. The more legs you add, the higher the reward but the lower the probability of winning.
Are parlays a smart betting strategy for college football?
Parlays can be fun for chasing large payouts but are harder to win consistently. Many sharp bettors prefer single-game wagers, but college football parlay bets can add excitement when used responsibly.
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