College Football Moneyline Parlay Picks: Best Week 2 Predictions at +1326 Odds

Our college football picks nearly landed us a winning ticket at +1061 odds last week, but we flat-out underestimated Auburn against Baylor, and now we're back at it again in our college football moneyline parlay picks for Week 2.

Now we're rolling with a nine-leg moneyline parlay to really juice up your Saturday.

My college football predictions for Week 2 include several teams looking to win outright on the road, and one road underdog out west. Plus, we take a stand on one of the most significant games on the slate as Oklahoma hosts Bryce Underwood and Michigan.

🏈 College football moneyline parlay picks: Week 2

College football parlay picks made Thursday; odds subject to change.

• Illinois (-152 via FanDuel) at Duke ⭐⭐⭐⭐⭐
• Ole Miss (-350 via FanDuel) at Kentucky ⭐⭐⭐⭐
• Rutgers (-750 via DraftKings) vs. Miami (OH) ⭐⭐⭐⭐
• Fresno State (+125 via bet365) at Oregon State ⭐⭐⭐⭐
• Colorado (-2500 via Caesars) vs. Delaware ⭐⭐⭐⭐⭐
• Florida (-900 via DraftKings) vs. South Florida ⭐⭐⭐⭐
• Oklahoma (-192 via FanDuel) vs. Michigan ⭐⭐⭐⭐⭐
• Kansas State (-833 via Caesars) vs. Army ⭐⭐⭐⭐
• Hawaii (-250 via Caesars) vs. Sam Houston State ⭐⭐⭐⭐

Best parlay odds: +1326 via Caesars ($10 to win $132.64)

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💰 Best moneyline picks for Week 2 parlay

Here are my favorite moneyline picks and best bets for Week 2 based on the best college football odds for the full parlay.

🚀 Illinois (-152) ⭐⭐⭐⭐⭐

Home-field advantage is significant for our best sports betting sites, so seeing Illinois favored on the road at Duke for Week 2 feels like it's happening for a reason.

The Blue Devils were a bit leaky against the run during their Week 1 win over Elon, allowing 163 rushing yards. Illinois can run the football, which its running backs showed last week while averaging 7.29 yards per carry and racking up 226 yards against Western Illinois.

🚀 Fresno State (+125) ⭐⭐⭐⭐

Another road team we like as a value proposition for our parlay in Week 2 is Fresno State. The Bulldogs took their lumps against Kansas in Week 0. But now they're coming off a 42-14 win over FBS Georgia Southern, and we think Fresno can catch a downtrodden Oregon State side napping.

The Beavers weren’t competitive against Cal during a 34-15 home loss last week. Fresno State’s EJ Warner needs to take better care of the football, but the Oregon State pass defense didn’t record an interception in Week 1. The Beavers may be ripe for the picking for Fresno's gunslinger.

🚀 Oklahoma (-192) ⭐⭐⭐⭐⭐

I’m not sold on Michigan, especially after the Wolverines didn’t even cover half the spread during an underwhelming 34-17 home win over New Mexico as 34.5-point favorites last week.

Though Oklahoma didn’t exactly blow away Illinois State (35-3 win as 35.5-point favorites), this Week 2 spot at home sets up far more favorably for the experienced John Mateer than it does for Michigan’s true freshman QB Bryce Underwood in a tough road environment.

Norman will be hyped for this matchup. OU should pull away for the win while also covering the 5-point spread.

💰 Best Week 2 parlay odds

Our college football player prop odds tool shows the best odds for every market across legal sportsbooks in your area.

❓ College football moneyline parlay FAQs

What is a parlay bet in college football?

A parlay combines multiple bets (spreads, totals, props, or moneylines) into one wager, with all selections needing to win for the bet to cash. Parlays are popular in college football betting because they offer bigger payouts.

How do college football parlay odds work?

Parlay odds are calculated by multiplying the odds of each individual selection, which increases both the potential payout and the risk. The more legs you add, the higher the reward but the lower the probability of winning.

Are parlays a smart betting strategy for college football?

Parlays can be fun for chasing large payouts but are harder to win consistently. Many sharp bettors prefer single-game wagers, but college football parlay bets can add excitement when used responsibly.

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