College Football Predictions & Odds for All Conference Championships
Last Updated: December 6, 2025 4:55 PM EST • 2 minute read X Social Google News Link
We have another five college football conference championship games to be decided today, with the MAC Championhsip, Big 12 Championship, SEC Championship, Big Ten Championship, and ACC Championship all on the line. Four conference titles were decided Friday night, with Kennesaw State (Conference USA), James Madison (Sun Belt), Boise State (Mountain West), and Tulane (American) all winning outright.
Our college football conference championship predictions offer up ATS and O/U picks, player props, same-game parlays, and anytime touchdown scorer predictions for all of today's action.
College football conference championship predictions: Week 15
Here are all of our college football expert picks for every conference championship, which we'll update throughout the week:
- Indiana vs. Ohio State prediction: Big Ten Championship
- Indiana vs. Ohio State player props: Big Ten Championship
- Indiana vs. Ohio State anytime touchdown scorer predictions: Big Ten Championship
- Indiana vs. Ohio State same-game parlay: Big Ten Championship
- Duke vs. Virginia prediction: ACC Championship
College football odds & expert picks: Saturday's conference championships
Indiana vs. Ohio State odds: Big Ten Championship
- Date: Saturday, Dec. 6
- Kickoff: 8 p.m. ET
- Location: Lucas Oil Stadium (Indianapolis)
- How to watch: FOX
Indiana vs. Ohio State prediction
🔴 Ohio State -4 (-110)
While Fernando Mendoza is the Heisman Trophy odds favorite, the projected No. 1 pick in the NFL draft has not seen a defense like Ohio State's this season. The Buckeyes are No. 1 in defensive SP+, top five in both EPA per rush and pass, allow the fewest yards per game in the country (203.0), and give up the fewest PPG in the nation (7.8).
- via my Indiana vs. Ohio State prediction
Duke vs. Virginia odds: ACC Championship
- Date: Saturday, Dec. 6
- Kickoff: 8 p.m. ET
- Location: Bank of America Stadium (Charlotte, N.C.)
- How to watch: ABC
Duke vs. Virginia prediction
😈 Duke +3.5 (-110)
The Virginia offensive line has some serious injury woes, and Duke has the quarterback advantage with Darian Mensah (155.7 passing efficiency score) clearing Chandler Morris (135.6) by a healthy margin. I have some concerns about a possible motivation split, but, with Duke head coach Manny Diaz believing the Blue Devils “absolutely” belong in the playoff with a win, let’s bet the dogs at +3.5 for -110.
- via Isaiah Sirois' Duke vs. Virginia prediction
College football conference championship expert picks: Week 15
- College football picks against the spread for every conference championship
- College football best bets conference championship week
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