College Football AI Predictions Week 2: ATS Picks & Score Projections for Top Games
After a wild opening weekend, our college football AI predictions take aim at the Week 2 schedule led by Michigan's trip to Oklahoma on Saturday.
While that's the only ranked matchup this weekend, there is still plenty of value on the board for your college football picks. We trained the latest and most advanced ChatGPT model to predict the top matchups every week while offering score predictions for the rest of this week's premier slate.
Looking for our (human) expert picks? We have you covered with all of our college football predictions for Week 2.
🤖 College football AI predictions for Week 2
College football AI predictions via ChatGPT simulation model with pick confidence based on a 1-to-5-star scale; check the latest college football odds for the best odds.
| Score prediction | ATS pick | Confidence |
|---|---|---|
| Iowa State 23, Iowa 16 | Iowa State -3.5 | ⭐⭐⭐⭐ |
| SMU 31, Baylor 24 | SMU -2.5 | ⭐⭐⭐⭐ |
| Duke 27, Illinois 24 | Duke +2.5 | ⭐⭐⭐ |
| NC State 28, Virginia 17 | NC State -3 | ⭐⭐⭐⭐ |
| Texas 45, San Jose State 10 | San Jose State +36.5 | ⭐⭐⭐ |
| Oregon 41, Oklahoma State 20 | Oklahoma State +28 | ⭐⭐⭐ |
| Colorado 38, Delaware 13 | Colorado -23.5 | ⭐⭐⭐ |
| Missouri 30, Kansas 24 | Kansas +6.5 | ⭐⭐⭐ |
| Ole Miss 31, Kentucky 20 | Ole Miss -9 | ⭐⭐⭐⭐ |
| Florida 34, South Florida 24 | South Florida +18 | ⭐⭐⭐⭐ |
| Kansas State 31, Army 10 | Kansas State -17 | ⭐⭐⭐⭐ |
| Toledo 27, Western Kentucky 24 | Western Kentucky +7 | ⭐⭐⭐⭐ |
| North Carolina 34, Charlotte 17 | North Carolina -13.5 | ⭐⭐⭐⭐ |
| Arizona State 33, Mississippi State 28 | Mississippi State +6.5 | ⭐⭐⭐ |
| Michigan State 24, Boston College 20 | Boston College +4.5 | ⭐⭐⭐ |
| Oklahoma 27, Michigan 20 | Oklahoma -5 | ⭐⭐⭐⭐ |
| Alabama 45, UL Monroe 10 | UL Monroe +35.5 | ⭐⭐⭐ |
| BYU 38, Stanford 13 | BYU -21.5 | ⭐⭐⭐⭐ |
🏈 Iowa vs. Iowa State prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Iowa | 3 | 3 | 7 | 3 | 16 |
| Iowa State | 7 | 6 | 7 | 3 | 23 |
🔢 Iowa State projected stats
- Passing leader: Rocco Becht - 21/32, 245 yards, 1 TD
- Rushing leader: Abu Sama III - 17 rushes, 89 yards, 1 TD
- Receiving leader: Ben Brahmer - 6 receptions, 72 yards, 1 TD
🔢 Iowa projected stats
- Passing leader: Mark Gronowski - 14/26, 152 yards, 1 TD, 1 INT
- Rushing leader: Xavier Williams - 18 rushes, 82 yards
- Receiving leader: Jacob Gill - 4 receptions, 56 yards, 1 TD
🆚 Iowa vs. Iowa State preview
Iowa State owns the cleaner offensive profile right now: Rocco Becht’s timing with TE Ben Brahmer and WR Brett Eskildsen gives the Cyclones reliable answers on third down, and Abu Sama III’s burst punishes light boxes. Iowa can grind with Xavier Williams behind a solid interior, but Mark Gronowski and a still-gelling receiver group face tighter throwing windows in Ames.
ISU’s continuity and red-zone efficiency tilt the leverage snaps, while Iowa’s margin rests on field position and takeaways. In a low-variance script, ISU’s balanced attack carries a one-score win.
🏈 Baylor vs. SMU prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Baylor | 7 | 3 | 7 | 7 | 24 |
| SMU | 10 | 7 | 7 | 7 | 31 |
🔢 SMU projected stats
- Passing leader: Kevin Jennings - 22/33, 278 yards, 2 TD, 1 INT
- Rushing leader: Chris Johnson Jr. - 15 rushes, 78 yardds, 1 TD
- Receiving leader: Romello Brinson - 5 receptions, 97 yards, 1 TD
🔢 Baylor projected stats
- Passing leader: Sawyer Robertson - 26/41, 296 yards, 2 TD, 1 INT
- Rushing leader: Bryson Washington - 14 rushes, 64 yards, 1 TD
- Receiving leader: Ashtyn Hawkins - 7 receptions, 88 yards, 1 TD
🆚 Baylor vs. SMU preview
Baylor’s quick-game and slot usage travel well, but SMU’s speed on the edges and a ball-hawking secondary tilt the leverage plays. Jennings is efficient off play-action and boot, and the Mustangs can stress Baylor’s safeties with vertical shots to Brinson while mixing in perimeter runs.
Baylor just surrendered explosives on the ground to Auburn; SMU’s tempo and short fields (it scored twice via defensive returns in Week 1) raise the pressure on Robertson to keep pace. SMU’s pass rush and takeaways create the late separation in Dallas.
🏈 Illinois vs. Duke prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Illinois | 3 | 10 | 7 | 4 | 24 |
| Duke | 7 | 6 | 7 | 7 | 27 |
🔢 Duke projected stats
- Passing leader: Darian Mensah - 23/34, 296 yards, 2 TD, 1 INT
- Rushing leader: Jaquez Moore - 14 rushes, 61 yards
- Receiving leader: Cooper Barkate - 6 receptions, 102 yards, 1 TD
🔢 Illinois projected stats
- Passing leader: Luke Altmyer - 20/31, 238 yards, 1 TD, 1 INT
- Rushing leader: Aidan Laughery - 16 rushes, 74 yards
- Receiving leader: Hank Beatty - 6 receptions, 84 yards, 1 TD
🆚 Illinois vs. Duke preview
Duke’s transfer QB Darian Mensah gives the Blue Devils a higher passing ceiling in Year 2 under Manny Diaz, especially with a deep WR room (Cooper Barkate, Sahmir Hagans, Que’Sean Brown) that can attack Illinois’ zones with RPO and quick-game rhythm.
Illinois travels well on the ground with Aidan Laughery behind a stable OL, but the Illini need Luke Altmyer to consistently win on third down to keep pace. With Duke settled at QB and balanced at RB (Jaquez Moore, Anderson Castle), the late-down edge and home field tilt a one-score game to the Blue Devils.
🏈 Ole Miss vs. Kentucky prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Ole Miss | 10 | 7 | 7 | 7 | 31 |
| Kentucky | 7 | 3 | 3 | 7 | 20 |
🔢 Ole Miss projected stats
- Passing leader: Austin Simmons - 24/36, 302 yards, 2 TD, 1 INT
- Rushing leader: Kewan Lacy - 16 rushes, 78 yards, 1 TD
- Receiving leader: Harrison Wallace III - 7 receptions, 104 yards, 1 TD
🔢 Kentucky projected stats
- Passing leader: Zach Calzada - 17/30, 198 yards, 1 TD, 1 INT
- Rushing leader: Dante Dowdell - 15 rushes, 88 yards, 1 TD
- Receiving leader: Ja’Mori Maclin - 5 receptions, 76 yards, 1 TD
🆚 Ole Miss vs. Kentucky preview
This sets up as Simmons’ first SEC road test against Brad White’s disciplined front, but the matchup leans to Ole Miss through the air. Kentucky allowed 270 passing yards in Week 1 while bottling up the run, so Kiffin can lean on tempo, play-action, and a deep transfer-boosted WR room (Wallace III, Stribling) to attack intermediate windows.
The Wildcats’ best script is Dowdell and McGowan shortening the game and keeping Calzada in manageable thirds, yet if the Rebels build an early lead, Kentucky’s pass game has to chase. With Simmons validated by a big debut and Lacy offering enough balance, our model favors Ole Miss by multiple scores in Lexington.
🏈 Michigan vs. Oklahoma prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Michigan | 3 | 7 | 7 | 3 | 20 |
| Oklahoma | 7 | 10 | 3 | 7 | 27 |
🔢 Oklahoma projected stats
- Passing leader: John Mateer - 21/33, 256 yards, 2 TD, 1 INT
- Rushing leader: Jaydn Ott - 16 rushes, 78 yards
- Receiving leader: Deion Burks - 6 receptions, 88 yards, 1 TD
🔢 Michigan projected stats
- Passing leader: Bryce Underwood - 20/31, 228 yards, 1 TD, 1 INT
- Rushing leader: Justice Haynes - 18 rushes, 94 yards, 1 TD
- Receiving leader: Semaj Morgan - 6 receptions, 72 yards
🆚 Michigan vs. Oklahoma preview
Oklahoma’s new Ben Arbuckle offense plays with pace and spacing, and John Mateer looks comfortable pushing throws to the slot and isolating Deion Burks outside. If Jaydn Ott threatens the perimeter on early downs, OU keeps Michigan out of its simulated-pressure looks and lives in manageable third downs.
The Wolverines counter with Bryce Underwood’s play-action menu under Chip Lindsey and a physical run game led by Alabama transfer Justice Haynes, but a rowdy night in Norman narrows the passing windows and stresses protection. With a few short fields and red-zone efficiency, OU has the smoother path to a one-score win.
💡 College football expert picks for Week 2
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