James Madison vs. Oregon Predictions: 2025 College Football Playoff Odds, Picks & Best Bet Tonight
In what's being viewed as the biggest mismatch in the first round of the College Football Playoff this year, my James Madison vs. Oregon predictions today project the Ducks to fly by the Dukes with ease.
Oregon is a 20.5-point betting favorite for Saturday's 7:30 p.m. ET (TNT/HBO Max/truTV) matchup from Autzen Stadium in Eugene, Ore., in the final first round CFP game among the college football bowl games this week.
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🏈 James Madison vs. Oregon prediction: 2025 College Football Playoff first round
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| College Football Playoff predictions | Odds | Confidence |
|---|---|---|
| Oregon -20.5 | -115 via DraftKings | ⭐⭐⭐⭐ |
| Kenyon Sadiq 2+ TDs | +450 via DraftKings | ⭐⭐⭐ |
Oregon -20.5 (-115) ⭐⭐⭐⭐
This is truly a David vs. Goliath matchup, except this time, David has no chance. If James Madison were playing another team in the first round, I'd have some belief they could cover. But this Oregon program is ranked No. 4 in the country by SP+.
The Ducks have a future top 10 pick at QB, a Joe Moore Award finalist O-line, and a defense full of future NFL players. The speed and size difference between these two teams is stark.
Alonza Barnett III is going to be under too much pressure to keep up with Dante Moore. Our James Madison vs. Oregon same-game parlay takes a closer look at Barnett.
Score prediction: Oregon 37, James Madison 13
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🙌 Best James Madison vs. Oregon TD pick: College Football Playoff first round
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Kenyon Sadiq, TE, Oregon: 2+ TDs (+450) ⭐⭐⭐⭐
No player taking the field will expose the difference in athleticism between a future NFL first-round pick and a Group of Six starter like Kenyon Sadiq. The Ducks' star pass catcher is expected to be the first tight end drafted in April, and likely in the top 20.
Sadiq is the definition of a freak, and with Moore throwing him the ball, he's poised to find the end zone against James Madison. However, he's been such a good bet to score that he's being priced between -136 and -163 to do so at our best college football betting sites.
That's why I'm taking a bigger swing and betting Sadiq to put two tuddies on the board against a defense that doesn't have a defender capable of stopping him down the seam or in contested catch situations.
Sadiq has scored two touchdowns in two of his previous five games, and can push a JMU defense that's been more susceptible against the pass than run this season.
And I'm not the only guy on our crew backing this play - our Philip Wood breaks it down in his James Madison vs. Oregon player prop bets, and Mike Spector features this play as one of his James Madison vs. Oregon anytime touchdown scorer predictions.
📝 Top NFL draft prospects for James Madison vs. Oregon
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| Player | Position | Key stats | NFL draft grade |
|---|---|---|---|
| Dante Moore, Oregon | QB | Lead country in big-time throw rate (7.9%) | Top 10 |
| Kenyon Sadiq, Oregon | TE | 490 receiving yards, 8 TDs | Top 20 |
| A'Mauri Washington, Oregon | IDL | 17 pressures, 17 run stops | Round 1-2 |
| Emmanuel Pregnon, Oregon | OG | 0 sacks, 3 pressures allowed | Round 2-3 |
| Matayo Uiagalelei, Oregon | EDGE | 41 pressures, 5 sacks | Round 2-3 |
| Dillon Thieneman, Oregon | SAF | 67 tackles, 2 INTs | Round 2-3 |
| Teitum Tuioti, Oregon | EDGE | 31 run stops, 7 sacks | Round 3-4 |
| Isaiah World, Oregon | OT | 1 sack, 10 pressures allowed | Round 3-5 |
| Bryce Boettcher, Oregon | LB | 104 tackles, 4 TFLs | Round 4-6 |
| Jacob Thomas, James Madison | SAF | Allowing 63.3 NFL QB rating in coverage | Round 7-UDFA |
📊 Live James Madison vs. Oregon odds: College Football Playoff first round
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James Madison vs. Oregon opening odds
- Moneyline: James Madison +900 | Oregon -1613
- Spread: James Madison +20.5 (-110) | Oregon -20.5 (-110)
- Over/Under: Over 50.5 (-110) | Under 50.5 (-110)
📈 James Madison vs. Oregon betting trends
| James Madison | Statistic | Oregon |
|---|---|---|
| 12-1 | W-L record | 11-1 |
| 8-5 | ATS record | 7-4-1 |
| 6-7 | O/U record | 6-6 |
| 6.4 | Yards per play | 7.1 |
| 4.1 | Yards allowed per play | 4.2 |
| 0.0 | Turnover margin | +0.6 |
| 5-0 | Last 5 games | 5-0 |
| W, 31-14 vs. Troy | Previous result | W, 26-14 vs. Washington |
📈 Most-bet anytime touchdown scorers today
Here are the most-bet anytime touchdown scorers during the College Football Playoff games today, via BetMGM.
- Kevin Concepcion (+100)
- Mark Fletcher Jr. (+140)
- Malachi Toney (-125)
- Marcel Reed (+155)
- Alonza Barnett III (+210)
📺 How to watch James Madison vs. Oregon: College Football Playoff
- Date: Saturday, Dec. 20
- Kickoff: 7:30 p.m. ET
- Location: Autzen Stadium (Eugene, Ore.)
- TV: TNT/HBO Max/truTV
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