Early Notre Dame vs. Arkansas Prediction, Odds & Picks: College Football Week 5

Last Updated: September 22, 2025 10:24 AM EDT • 4 minute read X Social Google News Link

My early Notre Dame vs. Arkansas prediction expects two of the country’s most explosive offenses to keep humming in this early kickoff as part of my college football predictions for Week 5.
Notre Dame is a 6-point betting favorite ahead of Saturday’s noon ET kickoff at Razorback Stadium in Fayetteville, Ark. (ABC).
My college football picks are backing the Over now in case the total increases throughout the week.
Notre Dame vs. Arkansas prediction & best bet
Stay ahead with the rest of our early college football predictions.
Over 64.5 (-110) ⭐⭐⭐⭐
Something feels tricky about Notre Dame being less than a touchdown favorite against an Arkansas team coming off two crushing one-score losses. So instead of deliberating over the side, my Notre Dame vs. Arkansas best bet backs the Over in a game featuring two explosive offenses matched up against struggling defenses.
Razorbacks quarterback Taylen Green has totaled 350-plus yards in five consecutive games. He leads all SEC quarterbacks in yards per game (387.8), in large part because he ranks third overall in the conference with 360 rushing yards. Earlier this season, he became the first quarterback in school history to throw for 300 yards and rush for 100 more in a single game.
The last time the Fighting Irish faced an elite dual-threat quarterback like Green, Marcel Reed totaled 397 yards and led Texas A&M to a 41-point outburst against Notre Dame, the most scored against the Fighting Irish since 2019.
Meanwhile, Notre Dame may have found its offensive identity for the rest of the season after bullying Purdue for 258 yards rushing and 6.6 yards per attempt. The Fighting Irish scored touchdowns on all three of their third-quarter possessions, which was impressive against a Purdue defense that had not allowed a second-half touchdown through the first three games.
Notre Dame should now be in line for several big plays against a Razorbacks defense that allowed five explosive plays (plays of 20-plus yards) in last week’s loss to Memphis.
Most of the best sports betting sites are offering the standard -110 juice (carrying a 52.38% implied probability) on both sides of the total, which offers a nice possible payout of $9.09 in profits on a winning $10 wager.
Notre Dame vs. Arkansas odds: Week 5
College football odds update live in real time.
Notre Dame vs. Arkansas opening odds
- Moneyline: Notre Dame -225 | Arkansas +184
- Spread: Notre Dame -6.5 (-110) | Arkansas +6.5 (-110)
- Over/Under: Over 58.5 (-110) | Under 58.5 (-110)
Notre Dame vs. Arkansas odds analysis
FanDuel is the only sportsbook that remains at Notre Dame -6.5, as all others lowered a half-point to -6. The Fighting Irish tend to be a very public team, and even though the initial movement was toward Arkansas, this number has a much better chance of getting back to -6.5 instead of lowering even further. Don’t count on the line ever reaching the key number of seven, though.
Notre Dame has scored 40 or more points in back-to-back games, while Arkansas has averaged 45 points through its first four. It was no surprise that the total is much different than the lookahead line of 58.5 and is already up another three points from the 61.5 that FanDuel opened with on Sunday morning.
This is a line that sharps are likely to get behind if the number balloons even further, especially since the Razorbacks only scored three points in the second half last week. Thus, if the total creeps to 65 or higher, look for respected bettors to drive the number back down, resulting in a total similar to what we are seeing now.
Notre Dame vs. Arkansas game info
- When: Saturday, Sept. 27
- Kickoff: Noon ET
- Where: Razorback Stadium (Fayetteville, Ark.)
- How to watch: ABC
Notre Dame vs. Arkansas FAQs
Who is favored to win Notre Dame vs. Arkansas?
Notre Dame is favored to win this game, with a moneyline of -225 at DraftKings that implies a 69.23% chance it will beat Arkansas. The best moneyline available for the Razorbacks is +185 at BetMGM, which implies a 35.09% chance they pull the upset.
How to watch Notre Dame vs. Arkansas?
Notre Dame vs. Arkansas can be watched on ABC on Saturday, Sept. 27 at noon ET.
What are the opening odds for Notre Dame vs. Arkansas?
Notre Dame opened as a 6.5-point favorite, and the spread has moved to 6 already. The total opened at 61.5 but has been steamed up to 64.5 given how explosive both offenses have been.
How do college football odds work?
When betting on college football odds, the point spread shows how many points the favorite needs to win by in order to cash the bet. For example, a favorite of -3 must win by more than 3 points to cover the spread, while an underdog at +3 must win outright or lose by fewer than 3 points to cover the spread.
Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total will be higher or lower than the set number.
You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.
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Mike Spector X social