Early LSU vs. Ole Miss Prediction, Odds & Picks: College Football Week 5
Looking ahead to another weekend of college football picks, my early LSU vs. Ole Miss prediction expects the explosive offense of the Rebels to challenge the Tiger defense in ways that Clemson and Florida simply weren’t capable of doing.
I’m already getting started with my college football predictions for Week 5, as I see early value on the point spread with Ole Miss listed as a 2.5-point betting favorite.
The action for LSU vs. Ole Miss kicks off from Vaught-Hemingway Stadium in Oxford, Miss., on Saturday at 3:30 p.m. ET (ABC).
🏈 LSU vs. Ole Miss prediction & best bet
Stay ahead with the rest of our early college football predictions.
🦈 Ole Miss -2.5 (-110) ⭐⭐⭐⭐
LSU’s defense has been one of the best in the country, allowing no more than 10 points in any of its first four games. But the challenge of the dynamic Ole Miss offense is one that the Tigers haven’t witnessed yet.
While wins over Clemson and Florida were impressive for LSU when they happened, opinions on the quality of those respective offenses have aged like milk. Clemson and Florida have combined to average just 30.8 PPG against FBS competition.
Ole Miss ranks 10th in the nation at 44.8 PPG. The Rebels are even more potent at home, averaging 49.7 PPG in Oxford. Meanwhile, the LSU offense - which has scored a paltry 20.0 PPG across three FBS matchups - is being questioned even when Brian Kelly doesn’t want it to be. LSU won’t be able to keep pace in this one.
FanDuel is offering Ole Miss -2.5 at -110 odds, which implies a 52.38% probability the Rebels will cover and pays a $9.09 profit on a $10 winning bet.
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📊 LSU vs. Ole Miss odds: Week 5
College football odds update live in real time.
📈 LSU vs. Ole Miss opening odds
- Moneyline: LSU +105 | Ole Miss -125
- Spread: LSU +1.5 (-110) | Ole Miss -1.5 (-110)
- Over/Under: Over 57.5 (-110) | Under 57.5 (-110)
🔍 LSU vs. Ole Miss odds analysis
Ole Miss opened as a 1.5-point favorite, and we’ve seen the line move already to -2.5, with 65% of wagers coming in on Ole Miss.
Ole Miss feels like the right side for any margin below a field goal, as their prowess on offense should make the Rebels one of the few units to pierce through an LSU defense that is playing at a high level, but against lesser competition, through four games.
Although it’s always possible to see the line move back the other way - and that feels more likely than does a move past the key number of 3 - I like the Rebels at home with a line of -3 or better, so I wouldn’t hesitate to bet this line early in the week.
📺 LSU vs. Ole Miss game info
- When: Saturday, Sept. 27
- Kickoff: 3:30 p.m. ET
- Where: Vaught-Hemingway Stadium (Oxford, Miss.)
- How to watch: ABC
💡 More NCAAF expert picks for Week 5
- Early Oregon vs. Penn State prediction
- Early Alabama vs. Georgia prediction
- Early Auburn vs. Texas A&M prediction
- Early USC vs. Illinois prediction
- Early LSU vs. Ole Miss prediction
- Early Notre Dame vs. Arkansas prediction
❓ LSU vs. Ole Miss FAQs
Who is favored to win LSU vs. Ole Miss?
Ole Miss is favored to win with -135 moneyline odds, which implies a 57.45% probability they will win. LSU is the underdog, with +115 moneyline odds, which implies a 46.51% probability they will win.
What are the opening odds for LSU vs. Ole Miss?
The spread for LSU vs. Ole Miss opened at Ole Miss -1.5. The total opened at 57.5.
How to watch LSU vs. Ole Miss
LSU vs. Ole Miss will be played Saturday, Sept. 27, at 3:30 p.m. ET, at Vaught-Hemingway Stadium in Oxford, Miss.
How do college football odds work?
When betting on college football odds, the point spread shows how many points the favorite needs to win by in order to cash the bet. For example, a favorite of -3 must win by more than 3 points to cover the spread, while an underdog at +3 must win outright or lose by fewer than 3 points to cover the spread.
Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total will be higher or lower than the set number.
You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.
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